Search Results - "Porta, Exequiel O. J"

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities by Porta, Exequiel O J, Kalesh, Karunakaran, Steel, Patrick G

“…Chagas disease is a vector-borne illness caused by the protozoan parasite ( ). It poses a significant public health burden, particularly in the poorest regions…”
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Editorial: The evolution in pharmacology of infectious diseases: 2022 by Porta, Exequiel O J, Saffaei, Ali, Kalesh, Karunakaran

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Lipophilic modification of salirasib modulates the antiproliferative and antimigratory activity by Ballari, María Sol, O. J. Porta, Exequiel, Zalazar, Evelyn Arel, Etichetti, Carla M. Borini, Padrón, José M., Girardini, Javier E., Labadie, Guillermo R.

“…[Display omitted] Salirasib, or farnesylthiosalicylic acid (FTS), is a salicylic acid derivative with demonstrated antineoplastic activity. While designed as a…”
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Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling by Porta, Exequiel O J, Isern, Jaime A, Kalesh, Karunakaran, Steel, Patrick G

“…Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus . Current treatments are limited by difficult administration, high cost, poor…”
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Repositioning Salirasib as a new antimalarial agent by Porta, Exequiel O. J, Bofill Verdaguer, Ignasi, Perez, Consuelo, Banchio, Claudia, Ferreira de Azevedo, Mauro, Katzin, Alejandro M, Labadie, Guillermo R

“…Malaria is a serious tropical disease that kills thousands of people every year, mainly in Africa, due to Plasmodium falciparum infections. Salirasib is a…”
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Tuning the Lewis acid phenol ortho-prenylation as a molecular diversity tool by Jäger, Sebastián N., Porta, Exequiel O. J., Labadie, Guillermo R.

“…A diversity-oriented approach for the synthesis of various structurally different prenylated alcohols from readily accessible and common precursors was…”
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Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles by Porta, Exequiel O J, Jäger, Sebastián N, Nocito, Isabel, Lepesheva, Galina I, Serra, Esteban C, Tekwani, Babu L, Labadie, Guillermo R

“…A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary…”
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Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases by Porta, Exequiel O.J., Ballari, María Sol, Carlucci, Renzo, Wilkinson, Shane, Ma, Guoyi, Tekwani, Babu L., Labadie, Guillermo R.

“…A series of thirty 1,2,3-triazolylsterols, inspired by azasterols with proven antiparasitic activity, were prepared by a stereocontrolled synthesis. Ten of…”
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Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves by Galles, Celina, Prez, Gastón M., Penkov, Sider, Boland, Sebastian, Porta, Exequiel O. J., Altabe, Silvia G., Labadie, Guillermo R., Schmidt, Ulrike, Knölker, Hans-Joachim, Kurzchalia, Teymuras V., de Mendoza, Diego

“…Proper cholesterol transport is crucial for the functionality of cells. In C . elegans , certain cholesterol derivatives called dafachronic acids (DAs) govern…”
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Synthesis and interaction of terminal unsaturated chemical probes with Mycobacterium tuberculosis CYP124A1 by Díaz-Storani, Luz, Clary, Anaelle A., Moreno, Diego M., Ballari, María Sol, Porta, Exequiel O.J., Bracca, Andrea B.J., Johnston, Jonathan B., Labadie, Guillermo R.

“…[Display omitted] A series of C15–C20 isoprenyl derivatives bearing terminal alkenyl and alkynyl groups were synthesized as possible substrates of the…”
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Convenient synthesis of the immunogenic glycolipid BbGL1 by Jäger, Sebastián N., Porta, Exequiel O.J., Labadie, Guillermo R.

“…[Display omitted] •Lyme disease is a “tick borne” illness that is rapidly spreading worldwide.•BbGL1 is a immunogenic glycolipid isolated from Borrelia…”
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A minimalistic approach to develop new anti-apicomplexa polyamines analogs by Panozzo-Zénere, Esteban A., Porta, Exequiel O.J., Arrizabalaga, Gustavo, Fargnoli, Lucía, Khan, Shabana I., Tekwani, Babu L., Labadie, Guillermo R.

“…The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a…”
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Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs by Porta, Exequiel O.J., Carvalho, Paulo B., Avery, Mitchell A., Tekwani, Babu L., Labadie, Guillermo R.

“…•We proposed synergistic effect of nitrogen and a heterocyclic ring.•A propargylamino steroid structure determined by X-ray crystallography.•Library was…”
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Experimental and theoretical studies of the [3,3]-sigmatropic rearrangement of prenyl azides by Porta, Exequiel O. J., Vallejos, Margarita M., Bracca, Andrea B. J., Labadie, Guillermo R.

“…[3,3]-Sigmatropic rearrangement of isoprenyl azides has been extensively investigated in an experimental and theoretical level. Prenylazides with different…”
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Activity-based protein profiling: A graphical review by Porta, Exequiel O J, Steel, Patrick G

“…Activity-based protein profiling (ABPP) is a chemoproteomic technology that employs small chemical probes to directly interrogate protein function within…”
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Tuning the Lewis acid phenol $$\varvec{ortho}$$ o r t h o -prenylation as a molecular diversity tool by Jäger, Sebastián N., Porta, Exequiel O. J., Labadie, Guillermo R.

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Repositioning Salirasib as a new antimalarial agent† †Electronic supplementary information (ESI) available: Detailed experimental procedures. Copies of the 1H and 13C NMR spectra of all new products. See DOI: 10.1039/c9md00298g by Porta, Exequiel O. J., Bofill Verdaguer, Ignasi, Perez, Consuelo, Banchio, Claudia, Ferreira de Azevedo, Mauro, Katzin, Alejandro M., Labadie, Guillermo R.

“…Repurposing strategies present an enormous advantage for drug discovery, especially in malaria, where resources are scarce. Malaria is a serious tropical…”
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Experimental and theoretical studies of the [3,3]-sigmatropic rearrangement of prenyl azidesElectronic supplementary information (ESI) available: NMR spectra of all synthesized compounds. Distances, topological properties and electron population along the Cartesian coordinates of the stationary points under study. See DOI: 10.1039/c7ra09759j by Porta, Exequiel O. J, Vallejos, Margarita M, Bracca, Andrea B. J, Labadie, Guillermo R

“…[3,3]-Sigmatropic rearrangement of isoprenyl azides has been extensively investigated in an experimental and theoretical level. Prenylazides with different…”
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Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazolesThe authors declare no competing interests.Electronic supplementary information (ESI) available: Detailed experimental procedures. Copies of 1H and 13C NMR spectra of all new products. See DOI: 10.1039/c7md00008a by Porta, Exequiel O. J, Jäger, Sebastián N, Nocito, Isabel, Lepesheva, Galina I, Serra, Esteban C, Tekwani, Babu L, Labadie, Guillermo R

“…A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary…”
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Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: Detailed experimental procedures. Copies of 1H and 13C NMR spectra of all new products. See DOI: 10.1039/c7md00008a by Porta, Exequiel O. J., Jäger, Sebastián N., Nocito, Isabel, Lepesheva, Galina I., Serra, Esteban C., Tekwani, Babu L., Labadie, Guillermo R.

“…A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. Most of the compounds were active against T. cruzi and L…”
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