Search Results - "Porszász, Róbert"

The Novel Cardiac Myosin Activator Danicamtiv Improves Cardiac Systolic Function at the Expense of Diastolic Dysfunction In Vitro and In Vivo: Implications for Clinical Applications by Ráduly, Arnold Péter, Sárkány, Fruzsina, Kovács, Máté Balázs, Bernát, Brigitta, Juhász, Béla, Szilvássy, Zoltán, Porszász, Róbert, Horváth, Balázs, Szentandrássy, Norbert, Nánási, Péter, Csanádi, Zoltán, Édes, István, Tóth, Attila, Papp, Zoltán, Priksz, Dániel, Borbély, Attila

“…Recent cardiotropic drug developments have focused on cardiac myofilaments. Danicamtiv, the second direct myosin activator, has achieved encouraging results in…”
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TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure by Phan, Thieu X., Ton, Hoai T., Gulyás, Hajnalka, Pórszász, Róbert, Tóth, Attila, Russo, Rebekah, Kay, Matthew W., Sahibzada, Niaz, Ahern, Gerard P.

“…Key points  The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves are unclear. We mapped TRPV1 in the mouse circulation, revealing…”
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Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans by Fülöp, Gábor Á., Oláh, Attila, Csipo, Tamas, Kovács, Árpád, Pórszász, Róbert, Veress, Roland, Horváth, Balázs, Nagy, László, Bódi, Beáta, Fagyas, Miklós, Helgadottir, Solveig Lind, Bánhegyi, Viktor, Juhász, Béla, Bombicz, Mariann, Priksz, Daniel, Nanasi, Peter, Merkely, Béla, Édes, István, Csanádi, Zoltán, Papp, Zoltán, Radovits, Tamás, Tóth, Attila

“…Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility. We tested the therapeutic range of OM and identified previously…”
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A Central Role for TRPM4 in Ca2+-Signal Amplification and Vasoconstriction by Csípő, Tamás, Czikora, Ágnes, Fülöp, Gábor Á., Gulyás, Hajnalka, Rutkai, Ibolya, Tóth, Enikő Pásztorné, Pórszász, Róbert, Szalai, Andrea, Bölcskei, Kata, Helyes, Zsuzsanna, Pintér, Erika, Papp, Zoltán, Ungvári, Zoltán, Tóth, Attila

“…Transient receptor potential melastatin-4 (TRPM4) is activated by an increase in intracellular Ca2+ concentration and is expressed on smooth muscle cells…”
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Carbonic Anhydrase Inhibitor Acetazolamide Enhances CHOP Treatment Response and Stimulates Effector T-Cell Infiltration in A20/BalbC Murine B-Cell Lymphoma by Méhes, Gábor, Matolay, Orsolya, Beke, Lívia, Czenke, Marianna, Pórszász, Róbert, Mikó, Edit, Bai, Péter, Berényi, Ervin, Trencsényi, György

“…The inhibition of cancer-related carbonic anhydrase (CA) activity is a promising way to intensify anti-tumor responses. In vitro data suggest improved efficacy…”
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Vanilloid Receptor-1 (TRPV1) Expression and Function in the Vasculature of the Rat by Tóth, Attila, Czikora, Ágnes, Pásztor, Enikő T., Dienes, Beatrix, Bai, Péter, Csernoch, László, Rutkai, Ibolya, Csató, Viktória, Mányiné, Ivetta S., Pórszász, Róbert, Édes, István, Papp, Zoltán, Boczán, Judit

“…Transient receptor potential (TRP) cation channels are emerging in vascular biology. In particular, the expression of the capsaicin receptor (TRPV1) was…”
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Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1 by Kark, Tamás, Bagi, Zsolt, Lizanecz, Erzsébet, Pásztor, Eniko T, Erdei, Nóra, Czikora, Agnes, Papp, Zoltán, Edes, István, Pórszász, Róbert, Tóth, Attila

“…The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca(2+)-permeable nonspecific cation channel activated by various painful…”
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An Unusual Hunting Accident: A Case Report by Borsay, Beáta Á, Halasi, Barbara D, Pórszász, Róbert K, Károlyi, Katalin, Gergely, Péter A

“…In Hungary, possessing certain weapons (e.g. firearms, bows, air pistols, and air guns mainly over 7.5 Joule muzzle velocity) is strictly regulated. In case of…”
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Different desensitization patterns for sensory and vascular TRPV1 populations in the rat: expression, localization and functional consequences by Czikora, Ágnes, Rutkai, Ibolya, Pásztor, Enikő T, Szalai, Andrea, Pórszász, Róbert, Boczán, Judit, Édes, István, Papp, Zoltán, Tóth, Attila

“…TRPV1 is expressed in sensory neurons and vascular smooth muscle cells, contributing to both pain perception and tissue blood distribution. Local…”
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TRPV1 in arteries enables a rapid myogenic tone by Phan, Thieu X., Ton, Hoai T., Gulyás, Hajnalka, Pórszász, Róbert, Tóth, Attila, Russo, Rebekah, Kay, Matthew W., Sahibzada, Niaz, Ahern, Gerard P.

“…Arterioles maintain blow flow by adjusting their diameter in response to changes in local blood pressure. In this process called the myogenic response, a…”
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Omecamtiv Mecarbil in the treatment of heart failure: the past, the present, and the future by Zhou, Shujing, Liu, Ying, Huang, Xufeng, Wu, Chuhan, Pórszász, Róbert

“…Heart failure, a prevailing global health issue, imposes a substantial burden on both healthcare systems and patients worldwide. With an escalating prevalence…”
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Importance of the details in person identification by Ágnes Borsay, Beáta, Dóra Halasi, Barbara, Kristóf Pórszász, Róbert, Attila Gergely, Péter

“…•The identification is one of the accentual question of a medico-legal autopsy.•Recognition of a mutilated corpse may not a reliable method.•The color of the…”
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Lethal threat in the use of glass doors at home: A case report by Halasi, Barbara Dóra, Borsay, Beáta Ágnes, Pórszász, Róbert Kristóf, Gergely, Péter Attila

“…Various instruments, including glass fragments, can inflict sharp-force damage, resulting in injuries ranging from superficial wounds to life-threatening…”
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Transglutaminase 2 Has Metabolic and Vascular Regulatory Functions Revealed by In Vivo Activation of Alpha1-Adrenergic Receptor by Lénárt, Kinga, Pap, Attila, Pórszász, Róbert, V Oláh, Anna, Fésüs, László, Mádi, András

“…The multifunctional tissue transglutaminase has been demonstrated to act as α1-adrenergic receptor-coupled G protein with GTPase activity in several cell…”
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Analysis of the effect of locally applied inhomogeneous static magnetic field-exposure on mouse ear edema--a double blind study by Kiss, Balázs, László, János F, Szalai, Andrea, Pórszász, Róbert

“…The effect static magnetic field (SMF)-exposure may exert on edema development has been investigated. A 6 h long whole-body (WBSMF) or local (LSMF),…”
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Exposure to static magnetic field delays induced preterm birth occurrence in mice by László, János F., PhD, Pórszász, Róbert, MD, PhD

“…Objective The purpose of this study was to demonstrate that daily 40-minute whole body exposure to an inhomogeneous static magnetic field (SMF) prolongs…”
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Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice by Újhelyi, Judit, Újhelyi, Zoltán, Szalai, Andrea, László, János F., Cayasso, Mayella, Vecsernyés, Miklós, Pórszász, Róbert

“…To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard…”
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Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice by László, János F., Szilvási, Judit, Fényi, Anett, Szalai, Andrea, Gyires, Klára, Pórszász, Róbert

“…Purpose: The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a…”
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The surmountable effect of FSCPX, an irreversible A1 adenosine receptor antagonist, on the negative inotropic action of A1 adenosine receptor full agonists in isolated guinea pig left atria by Gesztelyi, Rudolf, Kiss, Zsuzsanna, Wachal, Zita, Juhasz, Bela, Bombicz, Mariann, Csepanyi, Evelin, Pak, Krisztian, Zsuga, Judit, Papp, Csaba, Galajda, Zoltan, Branzaniuc, Klara, Porszasz, Robert, Szentmiklosi, Andras Jozsef, Tosaki, Arpad

“…A 1 adenosine receptors (A 1 receptors) are widely expressed in mammalian tissues; therefore attaining proper tissue selectivity is a cornerstone of drug…”
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Effect of capsaicin and resiniferatoxin on gastrointestinal blood flow in rats by Salam, Omar M.E.Abdel, Szolcsányi, János, Pórszász, Róbert, Mózsik, Gyula

“…The effect of capsaicin and resiniferatoxin on gastrointestinal blood flow was studied in anaesthetized rats by laser Doppler flowmetry. Resiniferatoxin…”
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