Search Results - "Porro, Fabiola"

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation by Chakraborty, Supriya, Martines, Claudio, Porro, Fabiola, Fortunati, Ilaria, Bonato, Alice, Dimishkovska, Marija, Piazza, Silvano, Yadav, Brijesh S., Innocenti, Idanna, Fazio, Rosa, Vaisitti, Tiziana, Deaglio, Silvia, Zamò, Alberto, Dimovski, Aleksandar J., Laurenti, Luca, Efremov, Dimitar G.

“…B-cell receptor (BCR) signals play a critical role in the pathogenesis of chronic lymphocytic leukemia (CLL), but their role in regulating CLL cell…”
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Promoterless gene targeting without nucleases rescues lethality of a Crigler‐Najjar syndrome mouse model by Porro, Fabiola, Bortolussi, Giulia, Barzel, Adi, De Caneva, Alessia, Iaconcig, Alessandra, Vodret, Simone, Zentilin, Lorena, Kay, Mark A, Muro, Andrés F

“…Crigler‐Najjar syndrome type I (CNSI) is a rare monogenic disease characterized by severe neonatal unconjugated hyperbilirubinemia with a lifelong risk of…”
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Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma by Sasi, Binu K., Martines, Claudio, Xerxa, Elena, Porro, Fabiola, Kalkan, Hilal, Fazio, Rosa, Turkalj, Sven, Bojnik, Engin, Pyrzynska, Beata, Stachura, Joanna, Zerrouqi, Abdessamad, Bobrowicz, Małgorzata, Winiarska, Magdalena, Priebe, Valdemar, Bertoni, Francesco, Mansouri, Larry, Rosenquist, Richard, Efremov, Dimitar G.

“…The BCL-2 inhibitor venetoclax has only limited activity in DLBCL despite frequent BCL-2 overexpression. Since constitutive activation of the B cell receptor…”
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CRISPR-Cas9-mediated somatic correction of a one-base deletion in the Ugt1a gene ameliorates hyperbilirubinemia in Crigler-Najjar syndrome mice by Bortolussi, Giulia, Iaconcig, Alessandra, Canarutto, Giulia, Porro, Fabiola, Ferrucci, Filippo, Galletta, Claudia, Díaz-Muñoz, Cristian, Rawat, Vipin, De Caneva, Alessia, Olajide, Olayemi Joseph, Zentilin, Lorena, Piazza, Silvano, Bočkor, Luka, Muro, Andrés Fernando

“…(AAV)-mediated episomal gene replacement therapy for monogenic liver disorders is currently limited in pediatric settings due to the loss of vector DNA,…”
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Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice by Lisjak, Michela, De Caneva, Alessia, Marais, Thibaut, Barbon, Elena, Biferi, Maria Grazia, Porro, Fabiola, Barzel, Adi, Zentilin, Lorena, Kay, Mark A, Mingozzi, Federico, Muro, Andrés F

“…Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative…”
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Generation of Ugt1-deficient murine liver cell lines using TALEN technology by Porro, Fabiola, Bockor, Luka, De Caneva, Alessia, Bortolussi, Giulia, Muro, Andrés F

“…The Crigler-Najjar Syndrome Type I (CNSI) is a rare genetic disorder caused by mutations in the Ugt1a1 gene. It is characterized by unconjugated…”
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A Major Fraction of Fibronectin Present in the Extracellular Matrix of Tissues Is Plasma-derived by Moretti, Federico A., Chauhan, Anil K., Iaconcig, Alessandra, Porro, Fabiola, Baralle, Francisco E., Muro, Andrés F.

“…The origin of the fibronectin (FN) found in the extracellular matrix of tissues has not been defined experimentally. Previous studies suggest that there is…”
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SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL by Sasi, Binu K, Turkalj, Sven, Kalkan, Hilal, Porro, Fabiola, Bojnik, Engin, Pyrzynska, Beata, Zerrouqi, Abdessamad, Bobrowicz, Malgorzata, Winiarska, Magdalena, Priebe, Valdemar, Bertoni, Francesco, Mansouri, Larry, Rosenquist, Richard, Efremov, Dimitar G

“…Functional and transcriptional profiling studies have identified a subset of diffuse large B cell lymphoma (DLBCL) tumors that rely on B cell receptor (BCR)…”
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Regulated Splicing of the Fibronectin EDA Exon Is Essential for Proper Skin Wound Healing and Normal Lifespan by Muro, Andrés F., Chauhan, Anil K., Gajovic, Srecko, Iaconcig, Alessandra, Porro, Fabiola, Stanta, Giorgio, Baralle, Francisco E.

“…Fibronectins (FNs) are multifunctional high molecular weight glycoproteins present in the blood plasma and in the ECMs of tissues. The FN primary transcript…”
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Characterization of the distal polyadenylation site of the ß-adducin (Add2) pre-mRNA by Costessi, Luisa, Porro, Fabiola, Iaconcig, Alessandra, Nedeljkovic, Mirjana, Muro, Andrés Fernando

“…Most genes have multiple polyadenylation sites (PAS), which are often selected in a tissue-specific manner, altering protein products and affecting mRNA…”
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Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice by Babaev, Vladimir R, Porro, Fabiola, Linton, MacRae F, Fazio, Sergio, Baralle, Francisco E, Muro, Andrés F

“…Abstract Atherosclerotic lesions are characterized by a profound alteration in the architecture of the arterial intima, with a marked increase of fibronectin…”
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TDP-43 regulates β-adducin (Add2) transcript stability by Costessi, Luisa, Porro, Fabiola, Iaconcig, Alessandra, Muro, Andrés F

“…TDP-43 is an RNA-binding protein involved in several steps of mRNA metabolism including transcription, splicing and stability. It is also involved in ALS and…”
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Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome by Chakraborty, Supriya, Martines, Claudio, Porro, Fabiola, Fortunati, Ilaria, Bonato, Alice, Dimishkovska, Marija, Yadav, Brijesh, Innocenti, Idanna, Fazio, Rosa, Vaisitti, Tizianna, Deaglio, Silvia, Zamò, Alberto, Dimovski, Aleksandar, Laurenti, Luca, Efremov, Dimitar G

“…B cell receptor (BCR) signals play a critical role in the pathogenesis of chronic lymphocytic leukemia (CLL), but their role in regulating CLL cell…”
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Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases by De Caneva, Alessia, Porro, Fabiola, Bortolussi, Giulia, Sola, Riccardo, Lisjak, Michela, Barzel, Adi, Giacca, Mauro, Kay, Mark A, Vlahoviček, Kristian, Zentilin, Lorena, Muro, Andrés F

“…Non-integrative AAV-mediated gene therapy in the liver is effective in adult patients, but faces limitations in pediatric settings due to episomal DNA loss…”
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Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL by Gobessi, Stefania, Laurenti, Luca, Porro, Fabiola, Martines, Claudio, Fazio, Rosa, Xerxa, Elena, Innocenti, Idanna, Zucchetto, Antonella, Chen, Shih-Shih, Yan, Xiao-Jie, Chiorazzi, Nicholas, Gattei, Valter, Efremov, Dimitar G

“…CLL cases display heterogeneous responses to B cell receptor (BCR) engagement which correlate with clinical course and survival. Typically, cases with more…”
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688. AAV8-Mediated Liver Gene Targeting Without Nucleases Rescues Lethality in a Mouse Model of the Crigler-Najjar Syndrome by Porro, Fabiola, Bortolussi, Giulia, Barzel, Adi, Zentilin, Lorena, Vodret, Simone, Bockor, Luka, Kay, Mark A., Muro, Andrés F.

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Characterization of the Distal Polyadenylation Site of the ß-Adducin by Costessi, Luisa, Porro, Fabiola, Iaconcig, Alessandra, Nedeljkovic, Mirjana, Muro, Andrés Fernando

“…Most genes have multiple polyadenylation sites (PAS), which are often selected in a tissue-specific manner, altering protein products and affecting mRNA…”
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Long-distance regulation of Add2 pre-mRNA3'end processing by Nedeljkovic, Mirjana, Costessi, Luisa, Iaconcig, Alessandra, Porro, Fabiola, Muro, Andrés F

“…Accurate 3'end processing depends on the correct recognition of polyadenylation regulatory elements by specific protein complexes. In addition to the…”
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Long-distance regulation of Add2 pre-mRNA3′end processing by Nedeljkovic, Mirjana, Costessi, Luisa, Iaconcig, Alessandra, Porro, Fabiola, Muro, Andrés F.

“…Accurate 3′end processing depends on the correct recognition of polyadenylation regulatory elements by specific protein complexes. In addition to the…”
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Characterization of the Distal Polyadenylation Site of the s-Adducin (Add2) Pre-mRNA. e58879 by Costessi, Luisa, Porro, Fabiola, Iaconcig, Alessandra, Nedeljkovic, Mirjana, Muro, Andres Fernando

“…Most genes have multiple polyadenylation sites (PAS), which are often selected in a tissue-specific manner, altering protein products and affecting mRNA…”
Get full text