Search Results - "Porras de Francisco, Esther"

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis by Warrier, Thulasi, Kapilashrami, Kanishk, Argyrou, Argyrides, Ioerger, Thomas R., Little, David, Murphy, Kenan C., Nandakumar, Madhumitha, Park, Suna, Gold, Ben, Mi, Jianjie, Zhang, Tuo, Meiler, Eugenia, Rees, Mike, Somersan-Karakaya, Selin, Francisco, Esther Porras-De, Martinez-Hoyos, Maria, Burns-Huang, Kristin, Roberts, Julia, Ling, Yan, Rhee, Kyu Y., Mendoza-Losana, Alfonso, Luo, Minkui, Nathan, Carl F.

“…The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the…”
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Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence by Dutta, Noton K, Klinkenberg, Lee G, Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S, Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C

“…The stringent response enables ( ) to shut down its replication and metabolism under various stresses. Here we show that lacking the stringent response enzyme…”
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Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis by Guardia, Ana, Baiget, Jessica, Cacho, Mónica, Pérez, Arancha, Ortega-Guerra, Montserrat, Nxumalo, Winston, Khanye, Setshaba D, Rullas, Joaquín, Ortega, Fátima, Jiménez, Elena, Pérez-Herrán, Esther, Fraile-Gabaldón, María Teresa, Esquivias, Jorge, Fernández, Raquel, Porras-De Francisco, Esther, Encinas, Lourdes, Alonso, Marta, Giordano, Ilaria, Rivero, Cristina, Miguel-Siles, Juan, Osende, Javier G, Badiola, Katrina A, Rutledge, Peter J, Todd, Matthew H, Remuiñán, Modesto, Alemparte, Carlos

“…Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of…”
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Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis by Lopez Quezada, Landys, Li, Kelin, McDonald, Stacey L, Nguyen, Quyen, Perkowski, Andrew J, Pharr, Cameron W, Gold, Ben, Roberts, Julia, McAulay, Kathrine, Saito, Kohta, Somersan Karakaya, Selin, Javidnia, Prisca Elis, Porras de Francisco, Esther, Amieva, Manuel Marin, Dı́az, Sara Palomo, Mendoza Losana, Alfonso, Zimmerman, Matthew, Liang, Hsin-Pin Ho, Zhang, Jun, Dartois, Veronique, Sans, Stéphanie, Lagrange, Sophie, Goullieux, Laurent, Roubert, Christine, Nathan, Carl, Aubé, Jeffrey

“…The historical view of β-lactams as ineffective antimycobacterials has given way to growing interest in the activity of this class against Mycobacterium…”
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Microwave‐Assisted Suzuki‐Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3‐Arylazetidine by Dequirez, Geoffroy, Bourotte, Marilyne, Porras de Francisco, Esther, Remuiñan Blanco, Modesto J., Déprez, Benoit, Willand, Nicolas

“…The efficient synthesis of 3‐arylazetidine derivatives is reported using a Nickel‐catalyzed Suzuki‐Miyaura coupling between arylboronic acids and a…”
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MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis by Moure, Abraham L, Narula, Gagandeep, Sorrentino, Flavia, Bojang, Adama, Tsui, Clement K. M, Sao Emani, Carine, Porras-De Francisco, Esther, Díaz, Beatriz, Rebollo-López, María José, Torres-Gómez, Pedro Alfonso, López-Román, Eva María, Camino, Isabel, Casado Castro, Patricia, Guijarro López, Laura, Ortega, Fátima, Ballell, Lluis, Barros-Aguirre, David, Remuiñán Blanco, Modesto, Av-Gay, Yossef

“…Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a thioalkyl­benzoxazole hit. Biological profiling and…”
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Identification of β‑Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions by Gold, Ben, Zhang, Jun, Quezada, Landys Lopez, Roberts, Julia, Ling, Yan, Wood, Madeleine, Shinwari, Wasima, Goullieux, Laurent, Roubert, Christine, Fraisse, Laurent, Bacqué, Eric, Lagrange, Sophie, Filoche-Rommé, Bruno, Vieth, Michal, Hipskind, Philip A, Jungheim, Louis N, Aubé, Jeffrey, Scarry, Sarah M, McDonald, Stacey L, Li, Kelin, Perkowski, Andrew, Nguyen, Quyen, Dartois, Véronique, Zimmerman, Matthew, Olsen, David B, Young, Katherine, Bonnett, Shilah, Joerss, Douglas, Parish, Tanya, Boshoff, Helena I, Arora, Kriti, Barry, Clifton E, Guijarro, Laura, Anca, Sara, Rullas, Joaquín, Rodríguez-Salguero, Beatriz, Martínez-Martínez, Maria S, Porras-De Francisco, Esther, Cacho, Monica, Barros-Aguirre, David, Smith, Paul, Berthel, Steven J, Nathan, Carl, Bates, Robert H

“…Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death…”
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Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis by Warrier, Thulasi, Martinez-Hoyos, Maria, Marin-Amieva, Manuel, Colmenarejo, Gonzalo, Porras-De Francisco, Esther, Alvarez-Pedraglio, Ana Isabel, Fraile-Gabaldon, Maria Teresa, Torres-Gomez, Pedro Alfonso, Lopez-Quezada, Landys, Gold, Ben, Roberts, Julia, Ling, Yan, Somersan-Karakaya, Selin, Little, David, Cammack, Nicholas, Nathan, Carl, Mendoza-Losana, Alfonso

“…Identification of compounds that target metabolically diverse subpopulations of Mycobacterium tuberculosis (Mtb) may contribute to shortening the course of…”
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Correction to “Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis” by Quezada, Landys Lopez, Li, Kelin, McDonald, Stacey L, Nguyen, Quyen, Perkowski, Andrew J, Pharr, Cameron W, Gold, Ben, Roberts, Julia, McAulay, Kathrine, Saito, Kohta, Karakaya, Selin Somersan, Javidnia, Prisca Elis, Porras de Francisco, Esther, Amieva, Manuel Marin, Palomo, Sara, Losana, Alfonso Mendoza, Zimmerman, Matthew, Ho Liang, Hsin-Pin, Zhang, Jun, Dartois, Veronique, Sans, Stéphanie, Lagrange, Sophie, Goullieux, Laurent, Roubert, Christine, Nathan, Carl, Aubé, Jeffrey

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