Search Results - "Porras, Gracia"

Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis by Martínez-González, Loreto, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Porras, Gracia, de Lago, Eva, Martín-Requero, Ángeles, Martínez, Ana

“…Amyotrophic Lateral Sclerosis (ALS) is the most common degenerative motor neuron disease in adults. About 97% of ALS patients present TDP-43 aggregates with…”
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Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts by Porras, Gracia, Ruiz, Silvana, Maestro, Inés, Borrego-Hernández, Daniel, Redondo, Alberto G, Martínez, Ana, Martín-Requero, Ángeles

“…The goal of this work was to elucidate the pathogenic mechanism of an ALS-associated missense mutation, p.Arg573Gly (R573G), in the gene. In particular, we…”
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Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations by Maestro, Ines, de la Ballina, Laura R., Porras, Gracia, Corrochano, Silvia, De Lago, Eva, Simonsen, Anne, Boya, Patricia, Martinez, Ana

“…Mitophagy is the selective degradation of mitochondria by autophagy. It promotes the turnover of mitochondria and prevents the accumulation of dysfunctional…”
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Molecular Alterations in Sporadic and SOD1 -ALS Immortalized Lymphocytes: Towards a Personalized Therapy by Lastres-Becker, Isabel, Porras, Gracia, Arribas-Blázquez, Marina, Maestro, Inés, Borrego-Hernández, Daniel, Boya, Patricia, Cerdán, Sebastián, García-Redondo, Alberto, Martínez, Ana, Martin-Requero, Ángeles

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition where motor neurons (MNs) degenerate. Most of the ALS cases are sporadic (sALS), whereas…”
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CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing by Tosat-Bitrián, Carlota, Avis-Bodas, Alicia, Porras, Gracia, Borrego-Hernández, Daniel, García-Redondo, Alberto, Martín-Requero, Angeles, Palomo, Valle

“…CdSe quantum dots (QDs) are valuable tools for deciphering molecular mechanisms in cells. Their conjugation with antibodies offers a unique staining source…”
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Regulation of the mhp Cluster Responsible for 3-(3-Hydroxyphenyl)propionic Acid Degradation in Escherichia coli by Torres, Begoña, Porras, Gracia, García, José L., Díaz, Eduardo

“…The mhp gene cluster from Escherichia coli constitutes a model system to study bacterial degradation of 3-(3-hydroxyphenyl)propionic acid (3HPP). In this work…”
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Leukocyte-endothelial cell interaction is enhanced in podocalyxin-deficient mice by Porras, Gracia, Ayuso, Matilde S., González-Manchón, Consuelo

“…The highly sialoglycosylated extracellular domain of podocalyxin (Podxl) is a constituent of the endothelial glycocalyx of most blood vessels but it is unknown…”
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Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients by Posa, Diana, Martínez-González, Loreto, Bartolomé, Fernando, Nagaraj, Siranjeevi, Porras, Gracia, Martínez, Ana, Martín-Requero, Ángeles

“…Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder of still unknown etiology that results in loss of motoneurons, paralysis,…”
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Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis by Martín-Cámara, Olmo, Arribas, Marina, Wells, Geoffrey, Morales-Tenorio, Marcos, Martín-Requero, Ángeles, Porras, Gracia, Martínez, Ana, Giorgi, Giorgio, López-Alvarado, Pilar, Lastres-Becker, Isabel, Menéndez, J. Carlos

“…Hybrid compounds containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids were designed with the aid…”
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Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) by Vaca, Gabriela, Martinez‐Gonzalez, Loreto, Fernandez, Ana, Rojas‐Prats, Elisa, Porras, Gracia, Cuevas, Eva P., Gil, Carmen, Martinez, Ana, Martin‐Requero, Ángeles

“…TDP‐43 has been identified as the major component of protein aggregates found in affected neurons in FTLD‐TDP and amyotrophic lateral sclerosis (ALS) patients…”
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Loss of endothelial barrier integrity in mice with conditional ablation of podocalyxin (Podxl) in endothelial cells by Horrillo, Angélica, Porras, Gracia, Ayuso, Matilde S., González-Manchón, Consuelo

“…Podocalyxin (Podxl) has an essential role in the development and function of the kidney glomerular filtration barrier. It is also expressed by vascular…”
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Multicentre physiological reference values for some urinary component-to-creatinine (creatininium) concentration ratios by Fuentes-Arderiu, Xavier, Mas-Serra, Roser, de-Nó-Lengaran, Carmen, Espejo-López, Francisco, Filgueiras-Martínez, Paula, Gassiot-Cordomí, Paula, Idoate-Cervantes, Isabel, Poncela-García, María Victoria, Porras-Gracia, Juan, Sanz-Lobo, Irene, Viloria-Peñas, María del Mar, Juvé-Cuxart, Santiago

“…Nine clinical laboratories in different regions of Spain have shared the search for reference individuals and the production of reference values for urinary…”
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Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation by Pérez de la Lastra Aranda, Carmen, Tosat-Bitrián, Carlota, Porras, Gracia, Dafinca, Ruxandra, Muñoz-Torrero, Diego, Talbot, Kevin, Martín-Requero, Ángeles, Martínez, Ana, Palomo, Valle

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that currently lacks effective therapy. Given the heterogeneity of clinical and…”
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Generation of mice with conditional ablation of the Cd40lg gene: new insights on the role of CD40L by Horrillo, Angélica, Fontela, Tomás, Arias-Salgado, Elena G., Llobat, Dolores, Porras, Gracia, Ayuso, Matilde S., González-Manchón, Consuelo

“…CD40 ligand (CD40L) acts as an immune modulator in activated T cells, and mutations in the extracellular domain are associated to X-linked hyper IgM syndrome…”
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Analytical performance evaluation of a particle-enhanced turbidimetric cystatin C assay on the Roche COBAS 6000 analyzer by Conde-Sánchez, Manuel, Roldán-Fontana, Esther, Chueca-Porcuna, Natalia, Pardo, Susana, Porras-Gracia, Juan

“…Cystatin C is a low molecular protein that has been proposed to estimate the glomerular filtration rate. Here we investigated the performance of the Roche…”
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SAFETY AND EFFICIENCY OF THE DOXAZOSIN GITS FORMULATION ON THE LEVEL OF BLOOD PRESSURE AND LIPID PROFILE IN ESSENTIALS HYPERTENSES RESISTANT TO MONOTHERAPY: P 737 by Espino-Montoro, A, Villalba-Alcala, F., Porras-Gracia, J., Cordobes-Lopez, J., Jimenez-Marin, A, Gonzalez-Fernandez, M C., Lopez-Chozas, J M

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SAFETY AND EFFICIENCY OF THE DOXAZOSIN GITS FORMULATION ON THE LEVEL OF BLOOD PRESSURE AND LIPID PROFILE IN ESSENTIALS HYPERTENSIVES RESISTANT TO MONOTHERAPY: P 723 by Espino-Montoro, A., Villalba-Alcala, F., Porras-Gracia, J., Cordobes-Lopez, J., Jimenez-Marin, A., Gonzalez-Fernandez, M C, Chozas, J M. Lopez

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RELATIONSHIP BETWEEN CARDIOVASCULAR RISK FACTORS AND BLOOD PRESSURE IN SUPINE DECUBITS ON DIABETICS TYPE 2 PATIENTS WITH HYPERLIPIDEMIA: P 352 by Espino-Montoro, A, Cordobes-Lopez, J., Villalbaca-Alcala, F., Porras-Gracia, J., Jimenez-Marin, A, Gonzalez-Fernandez, M C, de la Torre, E Merino, Lopez-Chozas, J M.

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