Search Results - "Porporato, Paolo"

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer by Brisson, Lucie, Bański, Piotr, Sboarina, Martina, Dethier, Coralie, Danhier, Pierre, Fontenille, Marie-Joséphine, Van Hée, Vincent F., Vazeille, Thibaut, Tardy, Morgane, Falces, Jorge, Bouzin, Caroline, Porporato, Paolo E., Frédérick, Raphaël, Michiels, Carine, Copetti, Tamara, Sonveaux, Pierre

“…Metabolic adaptability is essential for tumor progression and includes cooperation between cancer cells with different metabolic phenotypes. Optimal glucose…”
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Monocarboxylate transporters in cancer by Payen, Valéry L., Mina, Erica, Van Hée, Vincent F., Porporato, Paolo E., Sonveaux, Pierre

“…Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer…”
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A Mitochondrial Switch Promotes Tumor Metastasis by Porporato, Paolo E., Payen, Valéry L., Pérez-Escuredo, Jhudit, De Saedeleer, Christophe J., Danhier, Pierre, Copetti, Tamara, Dhup, Suveera, Tardy, Morgane, Vazeille, Thibaut, Bouzin, Caroline, Feron, Olivier, Michiels, Carine, Gallez, Bernard, Sonveaux, Pierre

“…Metastatic progression of cancer is associated with poor outcome, and here we examine metabolic changes underlying this process. Although aerobic glycolysis is…”
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Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis by Dhup, Suveera, Dadhich, Rajesh Kumar, Porporato, Paolo Ettore, Sonveaux, Pierre

“…High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis promotes energy production under hypoxia, aerobic glycolysis, the Warburg…”
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Energy metabolism in osteoclast formation and activity by Lemma, Silvia, Sboarina, Martina, Porporato, Paolo E., Zini, Nicoletta, Sonveaux, Pierre, Di Pompo, Gemma, Baldini, Nicola, Avnet, Sofia

“…[Display omitted] Osteoclastogenesis and osteolysis are energy-consuming processes supported by high metabolic activities. In human osteoclasts derived from…”
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Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells by De Saedeleer, Christophe J, Copetti, Tamara, Porporato, Paolo E, Verrax, Julien, Feron, Olivier, Sonveaux, Pierre

“…Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg…”
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Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway by Payen, Valéry L., Porporato, Paolo E., Baselet, Bjorn, Sonveaux, Pierre

“…Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are characterized by a high metabolic plasticity resulting from…”
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Cancer metabolism in space and time: Beyond the Warburg effect by Danhier, Pierre, Bański, Piotr, Payen, Valéry L, Grasso, Debora, Ippolito, Luigi, Sonveaux, Pierre, Porporato, Paolo E

“…Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several…”
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Lactate promotes glutamine uptake and metabolism in oxidative cancer cells by Pérez-Escuredo, Jhudit, Dadhich, Rajesh K, Dhup, Suveera, Cacace, Andrea, Van Hée, Vincent F, De Saedeleer, Christophe J, Sboarina, Martina, Rodriguez, Fabien, Fontenille, Marie-Joséphine, Brisson, Lucie, Porporato, Paolo E, Sonveaux, Pierre

“…Oxygenated cancer cells have a high metabolic plasticity as they can use glucose, glutamine and lactate as main substrates to support their bioenergetic and…”
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Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth by Li, Mingchuan, Sala, Valentina, De Santis, Maria Chiara, Cimino, James, Cappello, Paola, Pianca, Nicola, Di Bona, Anna, Margaria, Jean Piero, Martini, Miriam, Lazzarini, Edoardo, Pirozzi, Flora, Rossi, Luca, Franco, Irene, Bornbaum, Julia, Heger, Jacqueline, Rohrbach, Susanne, Perino, Alessia, Tocchetti, Carlo G, Lima, Braulio H.F, Teixeira, Mauro M, Porporato, Paolo E, Schulz, Rainer, Angelini, Annalisa, Sandri, Marco, Ameri, Pietro, Sciarretta, Sebastiano, Lima-Júnior, Roberto César P, Mongillo, Marco, Zaglia, Tania, Morello, Fulvio, Novelli, Francesco, Hirsch, Emilio, Ghigo, Alessandra

“…BACKGROUND:Anthracyclines, such as doxorubicin (DOX), are potent anticancer agents for the treatment of solid tumors and hematologic malignancies. However,…”
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Iron: An Essential Element of Cancer Metabolism by Hsu, Myriam Y, Mina, Erica, Roetto, Antonella, Porporato, Paolo E

“…Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in a hostile environment characterized by nutrient deprivation, poor…”
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Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter by Payen, Valéry L, Hsu, Myriam Y, Rädecke, Kristin S, Wyart, Elisabeth, Vazeille, Thibaut, Bouzin, Caroline, Porporato, Paolo E, Sonveaux, Pierre

“…Extracellular acidosis resulting from intense metabolic activities in tumors promotes cancer cell migration, invasion, and metastasis. Although host cells die…”
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Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism by Porporato, Paolo E., Payen, Valéry L., Baselet, Bjorn, Sonveaux, Pierre

“…Metabolic alterations are a hallmark of cancer controlling tumor progression and metastasis. Among the various metabolic phenotypes encountered in tumors, this…”
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Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review by Porporato, Paolo E, Dhup, Suveera, Dadhich, Rajesh K, Copetti, Tamara, Sonveaux, Pierre

“…CANCER IS A METABOLIC DISEASE AND THE SOLUTION OF TWO METABOLIC EQUATIONS: to produce energy with limited resources and to fulfill the biosynthetic needs of…”
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Cachexia, a Systemic Disease beyond Muscle Atrophy by Wyart, Elisabeth, Bindels, Laure B, Mina, Erica, Menga, Alessio, Stanga, Serena, Porporato, Paolo E

“…Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the…”
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PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing by Chereddy, Kiran Kumar, Her, Charles-Henry, Comune, Michela, Moia, Claudia, Lopes, Alessandra, Porporato, Paolo E., Vanacker, Julie, Lam, Martin C., Steinstraesser, Lars, Sonveaux, Pierre, Zhu, Huijun, Ferreira, Lino S., Vandermeulen, Gaëlle, Préat, Véronique

“…Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Poly (lactic-co-glycolic acid) (PLGA) supplies…”
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NAD+ repletion with niacin counteracts cancer cachexia by Beltrà, Marc, Pöllänen, Noora, Fornelli, Claudia, Tonttila, Kialiina, Hsu, Myriam Y., Zampieri, Sandra, Moletta, Lucia, Corrà, Samantha, Porporato, Paolo E., Kivelä, Riikka, Viscomi, Carlo, Sandri, Marco, Hulmi, Juha J., Sartori, Roberta, Pirinen, Eija, Penna, Fabio

“…Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial…”
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Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential by Anemone, Annasofia, Consolino, Lorena, Conti, Laura, Irrera, Pietro, Hsu, Myriam Y., Villano, Daisy, Dastrù, Walter, Porporato, Paolo E., Cavallo, Federica, Longo, Dario Livio

“…Background Tumour acidosis is considered to play a central role in promoting cancer invasion and migration, but few studies have investigated in vivo how…”
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Pro- and antitumor effects of mitochondrial reactive oxygen species by Payen, Valéry L., Zampieri, Luca X., Porporato, Paolo E., Sonveaux, Pierre

“…In cancer, mitochondrial functions are commonly altered. Directly involved in metabolic reprogramming, mitochondrial plasticity confers to cancer cells a high…”
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Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia by Wyart, Elisabeth, Hsu, Myriam Y, Sartori, Roberta, Mina, Erica, Rausch, Valentina, Pierobon, Elisa S, Mezzanotte, Mariarosa, Pezzini, Camilla, Bindels, Laure B, Lauria, Andrea, Penna, Fabio, Hirsch, Emilio, Martini, Miriam, Mazzone, Massimiliano, Roetto, Antonella, Geninatti Crich, Simonetta, Prenen, Hans, Sandri, Marco, Menga, Alessio, Porporato, Paolo E

“…Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in…”
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