Search Results - "Porowska, Anna"

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers by Mietelska-Porowska, Anna, Wojda, Urszula

“…Alzheimer’s disease (AD) is a chronic neurodegenerative disorder and the main cause of dementia. The disease is among the leading medical concerns of the…”
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Tau protein modifications and interactions: their role in function and dysfunction by Mietelska-Porowska, Anna, Wasik, Urszula, Goras, Marcelina, Filipek, Anna, Niewiadomska, Grazyna

“…Tau protein is abundant in the central nervous system and involved in microtubule assembly and stabilization. It is predominantly associated with axonal…”
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The cholinergic system, nerve growth factor and the cytoskeleton by Niewiadomska, Grazyna, Mietelska-Porowska, Anna, Mazurkiewicz, Marcin

“…Cholinergic neurons of the basal forebrain provide the major cholinergic innervation to the cortex and hippocampus, and play a key role in memory and…”
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Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease by Wiȩckowska-Gacek, Angelika, Mietelska-Porowska, Anna, Chutorański, Dominik, Wydrych, Małgorzata, Długosz, Jan, Wojda, Urszula

“…Alzheimer's disease (AD) is an aging-dependent, irreversible neurodegenerative disorder and the most common cause of dementia. The prevailing AD hypothesis…”
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Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet by Mietelska-Porowska, Anna, Domańska, Justyna, Want, Andrew, Więckowska-Gacek, Angelika, Chutorański, Dominik, Koperski, Maciej, Wojda, Urszula

“…The term Western diet (WD) describes the consumption of large amounts of highly processed foods, rich in simple sugars and saturated fats. Long-term WD feeding…”
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Influence of Feed Composition and Drying Parameters on the Surface Composition of a Spray-Dried Multicomponent Particle by Porowska, Anna, Dosta, Maksym, Heinrich, Stefan, Fries, Lennart, Gianfrancesco, Alessandro, Palzer, Stefan

“…Surface properties of multicomponent particles produced in spray drying can be controlled by selective accumulation of specific components, which are present…”
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Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease by Mietelska-Porowska, Anna, Gasiorowska, Anna, Niewiadomski, Wiktor, Palasz, Ewelina, Niewiadomska, Grazyna

“…Physical training confers protection to dopaminergic neurons in rodent models of parkinsonism produced by neurotoxins. The sparing effect of physical training…”
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Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice by Jermakow, Natalia, Skarżyńska, Weronika, Lewandowska, Katarzyna, Kiernozek, Ewelina, Goździk, Katarzyna, Mietelska-Porowska, Anna, Drela, Nadzieja, Wojda, Urszula, Doligalska, Maria

“…Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune…”
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Palm Oil-Rich Diet Affects Murine Liver Proteome and S -Palmitoylome by Ziemlińska, Ewelina, Sobocińska, Justyna, Świątkowska, Anna, Hromada-Judycka, Aneta, Traczyk, Gabriela, Malinowska, Agata, Świderska, Bianka, Mietelska-Porowska, Anna, Ciesielska, Anna, Kwiatkowska, Katarzyna

“…Palmitic acid (C16:0) is the most abundant saturated fatty acid in animals serving as a substrate in synthesis and β-oxidation of other lipids, and in the…”
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Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration by Więckowska-Gacek, Angelika, Mietelska-Porowska, Anna, Wydrych, Małgorzata, Wojda, Urszula

“…[Display omitted] •Western diet (WD) can accelerate and enhance inflammaging and induction of Alzheimer’s disease (AD).•WD-induced obesity, metabolic disorders…”
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Systemic inflammation induced by LPS promotes insulin signaling disruption leading to Alzheimer‐like changes in wild type mice by Domańska, Justyna, Więckowska‐Gacek, Angelika, Wojda, Urszula, Mietelska‐Porowska, Anna

“…Background One of the hypotheses for the ethiology of sporadic Alzheimer’s disease (AD) focuses on systemic inflammation as a driving force of aging. Another…”
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Search for Alzheimer's disease biomarkers in blood cells: hypotheses-driven approach by Wojsiat, Joanna, Laskowska-Kaszub, Katarzyna, Mietelska-Porowska, Anna, Wojda, Urszula

“…Current Alzheimer's disease (AD) diagnostics is based on cognitive testing, and detecting amyloid Aβ and τ pathology by brain imaging and assays of…”
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Greater sensitivity of the hippocampus than the entorhinal cortex in response to western diet, manifested by accelerated neuroinflammation and neurodegeneration in the progression of Alzheimer’s disease by Więckowska‐Gacek, Angelika, Mietelska‐Porowska, Anna, Domańska, Justyna Marta, Wojda, Urszula

“…Background The western diet (WD), characterized by a combination of simple carbohydrates, saturated fatty acids and cholesterol, is known to induce metabolic…”
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Brain insulin resistance and Alzheimer’s molecular changes induced by Western diet by Domańska, Justyna Marta, Mietelska‐Porowska, Anna, Want, Andrew, Wieckowska‐Gacek, Angelika, Wojda, Urszula

“…Background Western diet (WD) is a type of nourishment based on ultra‐processed foods, rich in simple sugars and saturated fats. Long‐term consumption of WD may…”
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WESTERN DIET – FROM MICROGLIA DYSFUNCTION TO THE ACCELERATION OF ALZHEIMER'S DISEASE PATHOLOGY by Więckowska‑Gacek, Angelika, Mietelska‑Porowska, Anna, Domańska, Justyna, Wojda, Urszula

“…Microglial phagocytosis in the early stage of Alzheimer's disease (AD) plays a beneficial role, however, during disease progression, seems to become…”
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WESTERN DIET AS A TRIGGER OF ALZHEIMER'S DISEASE: FROM METABOLIC SYNDROME TO NEURODEGENERATION by Mietelska-Porowska, Anna, Domańska, Justyna, Więckowska‑Gacek, Angelika, Want, Andrew, Chutorański, Dominik, Wojda, Urszula

“…An excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor of Alzheimer's disease (AD) but the holistic view of the…”
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WESTERN DIET LEADS TO INSULIN RESISTANCE IN THE BRAIN AND MAY TRIGGER THE DEVELOPMENT OF ALZHEIMER'S DISEASE by Domańska, Justyna, Mietelska‑Porowska, Anna, Want, Andrew, Więckowska‑Gacek, Angelika, Chutorański, Dominik, Koperski, Maciej, Wojda, Urszula

“…Western diet (WD) is a type of nourishment based on ultra-processed foods. Long-term consumption of WD leads to disruption of insulin signaling and the…”
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Predicting the surface composition of a spray-dried particle by modelling component reorganization in a drying droplet by Porowska, Anna, Dosta, Maksym, Fries, Lennart, Gianfrancesco, Alessandro, Heinrich, Stefan, Palzer, Stefan

“…•The model predicts composition in the surface of a dried multicomponent particle.•Enrichment of the surface in the slowly diffusing component by 10–150% was…”
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Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride by Mietelska-Porowska, Anna, Gasiorowska, Anna, Palasz, Ewelina, Koss, Dave J., Riedel, Gernot, Niewiadomska, Grazyna

“…•exogenous hTau441 penetrates the hippocampal cells in presence of Poly-APS neurotoxin.•seeding tau became phosphorylated when okadaic acid was infused to the…”
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A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe by Zdioruk, Mykola, Want, Andrew, Mietelska-Porowska, Anna, Laskowska-Kaszub, Katarzyna, Wojsiat, Joanna, Klejman, Agata, Użarowska, Ewelina, Koza, Paulina, Olejniczak, Sylwia, Pikul, Stanislaw, Konopka, Witold, Golab, Jakub, Wojda, Urszula

“…Induction of mitotic catastrophe through the disruption of microtubules is an established target in cancer therapy. However, the molecular mechanisms…”
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