Search Results - "Porokuokka, L. Lauriina"
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GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
Published in PLoS genetics (01-12-2015)“…Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF)…”
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Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
Published in PLoS genetics (2016)“…[This corrects the article DOI: 10.1371/journal.pgen.1005710.]…”
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Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
Published in Molecular psychiatry (2022)“…Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood. Here, we…”
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Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF
Published in The Journal of neuroscience (08-02-2017)“…Midbrain dopamine neuron dysfunction contributes to various psychiatric and neurological diseases, including drug addiction and Parkinson's disease. Because of…”
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Interindividual Variation in Gut Nitrergic Neuron Density Is Regulated By GDNF Levels and ETV1
Published in Cellular and molecular gastroenterology and hepatology (01-01-2024)“…The size and function of the enteric nervous system (ENS) can vary substantially between individuals. Because ENS function is involved in the etiology of a…”
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Gfra1 Underexpression Causes Hirschsprung’s Disease and Associated Enterocolitis in Mice
Published in Cellular and molecular gastroenterology and hepatology (01-01-2019)“…Background & Aims RET, the receptor for the glial cell line–derived neurotrophic factor (GDNF) family ligands, is the most frequently mutated gene in…”
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Interindividual Variation in Gut Nitrergic Neuron Density Is Regulated By GDNF Levels and ETV1Summary
Published in Cellular and molecular gastroenterology and hepatology (01-01-2024)“…Background & Aims: The size and function of the enteric nervous system (ENS) can vary substantially between individuals. Because ENS function is involved in…”
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Journal Article -
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Gfra1 Underexpression Causes Hirschsprung’s Disease and Associated Enterocolitis in MiceSummary
Published in Cellular and molecular gastroenterology and hepatology (01-01-2019)“…Background & Aims: RET, the receptor for the glial cell line–derived neurotrophic factor (GDNF) family ligands, is the most frequently mutated gene in…”
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Journal Article -
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GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function: e1005710
Published in PLoS genetics (01-12-2015)“…Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF)…”
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Journal Article