Search Results - "Porco, John A"

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis by Kärkäs, Markus D, Porco, John A, Stephenson, Corey R. J

“…The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple…”
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Dearomatization Strategies in the Synthesis of Complex Natural Products by Roche, Stéphane P., Porco Jr, John A.

“…Evolution in the field of the total synthesis of natural products has led to exciting developments over the last decade. Numerous chemoselective and…”
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Total Syntheses of Secalonic Acids A and D by Qin, Tian, Porco Jr, John A.

“…Total syntheses of the dimeric tetrahydroxanthone natural products secalonic acids A and D are described. Key steps involve kinetic resolution of the…”
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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus by Whitesell, Luke, Robbins, Nicole, Huang, David S., McLellan, Catherine A., Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle V., Nation, Catherine S., Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin L., Krysan, Damian J., Lindquist, Susan, Porco, John A., Tatu, Utpal, Brown, Lauren E., Pizarro, Juan, Cowen, Leah E.

“…New strategies are needed to counter the escalating threat posed by drug-resistant fungi. The molecular chaperone Hsp90 affords a promising target because it…”
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Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids by Mitsuhashi, Takaaki, Barra, Lena, Powers, Zachary, Kojasoy, Volga, Cheng, Andrea, Yang, Feng, Taniguchi, Yoshimasa, Kikuchi, Takashi, Fujita, Makoto, Tantillo, Dean J., Porco, John A., Abe, Ikuro

“…Fungal meroterpenoids are a diverse group of hybrid natural products with impressive structural complexity and high potential as drug candidates. In this work,…”
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Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach by Yang, Feng, Porco, John A.

“…3,5-Dimethylorsellinic acid (DMOA)-derived spiromeroterpenoids are a unique natural product family with attractive structures, unconventional stereochemistry,…”
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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer by Wolfe, Andrew L., Singh, Kamini, Zhong, Yi, Drewe, Philipp, Rajasekhar, Vinagolu K., Sanghvi, Viraj R., Mavrakis, Konstantinos J., Jiang, Man, Roderick, Justine E., Van der Meulen, Joni, Schatz, Jonathan H., Rodrigo, Christina M., Zhao, Chunying, Rondou, Pieter, de Stanchina, Elisa, Teruya-Feldstein, Julie, Kelliher, Michelle A., Speleman, Frank, Porco, John A., Pelletier, Jerry, Rätsch, Gunnar, Wendel, Hans-Guido

“…The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational…”
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Triple-Dearomative Photocycloaddition: A Strategy to Construct Caged Molecular Frameworks by Ji, Kaijie, Parthiban, Jayachandran, Jockusch, Steffen, Sivaguru, Jayaraman, Porco, John A.

“…An unprecedented caged 2H-benzo-dioxo-pentacycloundecane framework was serendipitously obtained in a single transformation via triple-dearomative…”
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Asymmetric, Stereodivergent Synthesis of (−)-Clusianone Utilizing a Biomimetic Cationic Cyclization by Boyce, Jonathan H., Porco Jr, John A.

“…We report a stereodivergent, asymmetric total synthesis of (−)‐clusianone in six steps from commercial materials. We implement a challenging cationic…”
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Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt by Ji, Kaijie, Johnson, Richard P., McNeely, James, Al Faruk, Md, Porco, John A.

“…Nidulaxanthone A is a dimeric, dihydroxanthone natural product that was isolated in 2020 from Aspergillus sp. Structurally, the compound features an…”
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Polycyclic xanthone natural products: structure, biological activity and chemical synthesis by Winter, Dana K, Sloman, David L, Porco, Jr, John A

“…Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last…”
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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling by Shaashua, Lee, Ben-Shmuel, Aviad, Pevsner-Fischer, Meirav, Friedman, Gil, Levi-Galibov, Oshrat, Nandakumar, Subhiksha, Barki, Debra, Nevo, Reinat, Brown, Lauren E., Zhang, Wenhan, Stein, Yaniv, Lior, Chen, Kim, Han Sang, Bojmar, Linda, Jarnagin, William R., Lecomte, Nicolas, Mayer, Shimrit, Stok, Roni, Bishara, Hend, Hamodi, Rawand, Levy-Lahad, Ephrat, Golan, Talia, Porco, John A., Iacobuzio-Donahue, Christine A., Schultz, Nikolaus, Tuveson, David A., Lyden, David, Kelsen, David, Scherz-Shouval, Ruth

“…Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer cells with non-malignant cells of the tumor microenvironment…”
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Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization by Powers, Zachary, Scharf, Adam, Cheng, Andrea, Yang, Feng, Himmelbauer, Martin, Mitsuhashi, Takaaki, Barra, Lena, Taniguchi, Yoshimasa, Kikuchi, Takashi, Fujita, Makoto, Abe, Ikuro, Porco, John A.

“…A biomimetic route to farnesyl pyrophosphate and dimethyl orsellinic acid (DMOA)‐derived meroterpenoid scaffolds has yet to be reported despite great interest…”
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Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (−)-Nemorosone and (−)-6-epi-Garcimultiflorone A by Wen, Saishuai, Boyce, Jonathan H, Kandappa, Sunil K, Sivaguru, Jayaraman, Porco, John A

“…Regiodivergent photocyclization of dearomatized acylphloroglucinol substrates has been developed to produce type A polycyclic polyprenylated acylphloroglucinol…”
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How proteins bind macrocycles by Villar, Elizabeth A, Beglov, Dmitri, Chennamadhavuni, Spandan, Porco, John A, Kozakov, Dima, Vajda, Sandor, Whitty, Adrian

“…Macrocycles have the potential to act on currently undruggable targets, but their discovery thus far has been unsystematic. A physicochemical analysis of all…”
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Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis by Cong, Huan, Porco, John A

“…Nanoparticle catalysis has emerged as an active topic in organic synthesis. Of particular interest is the development of enabling methodologies to efficiently…”
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CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A by Chu, Jennifer, Galicia-Vázquez, Gabriela, Cencic, Regina, Mills, John R., Katigbak, Alexandra, Porco, John A., Pelletier, Jerry

“…Targeting translation initiation is an emerging anti-neoplastic strategy that capitalizes on de-regulated upstream MAPK and PI3K-mTOR signaling pathways in…”
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Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate by Qin, Xu‐Jie, Rauwolf, Tyler J., Li, Pan‐Pan, Liu, Hui, McNeely, James, Hua, Yan, Liu, Hai‐Yang, Porco, John A.

“…Rhodomyrtusials A–C, the first examples of triketone‐sesquiterpene meroterpenoids featuring a unique 6/5/5/9/4 fused pentacyclic ring system were isolated from…”
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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F by Chu, Jennifer, Zhang, Wenhan, Cencic, Regina, O’Connor, Patrick B.F., Robert, Francis, Devine, William G., Selznick, Asher, Henkel, Thomas, Merrick, William C., Brown, Lauren E., Baranov, Pavel V., Porco, John A., Pelletier, Jerry

“…Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in…”
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Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of DMOA-Derived Spiromeroterpenoids by Yang, Feng, Oladokun, Amira, Porco, John A.

“…DMOA-derived spiromeroterpenoids are a group of natural products with complex structures and varied biological activities. Recently, we reported the first…”
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