Search Results - "Porco, J A"

Correction: Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein by Jin, C., Rajabi, H., Rodrigo, C. M., Porco, J. A., Kufe, D.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01727-3…”
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eIF4F suppression in breast cancer affects maintenance and progression by Nasr, Z, Robert, F, Porco, J A, Muller, W J, Pelletier, J

“…Levels of eukaryotic initiation factor 4E (eIF4E) are frequently elevated in human cancers and in some instances have been associated with poor prognosis and…”
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Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein by Jin, C, Rajabi, H, Rodrigo, C M, Porco, J A, Kufe, D

“…The oncogenic MUC1 C-terminal subunit (MUC1-C) subunit is aberrantly overexpressed in most human breast cancers by mechanisms that are not well understood. The…”
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Applying Computer-Assisted Structure Elucidation Algorithms for the Purpose of Structure Validation: Revisiting the NMR Assignments of Hexacyclinol by Williams, A. J, Elyashberg, M. E, Blinov, K. A, Lankin, D. C, Martin, G. E, Reynolds, W. F, Porco, J. A, Singleton, C. A, Su, S

“…Computer-assisted structure elucidation (CASE) using a combination of 1D and 2D NMR data has been available for a number of years. These algorithms can be…”
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Parallel synthesis of 1,2,4-oxadiazoles using CDI activation by Deegan, Tracy L, Nitz, Theodore J, Cebzanov, Diane, Pufko, Denise E, Porco, John A

“…1,2,4-Oxadiazoles have been prepared in parallel using 1,1′-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl…”
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Modification of C-Terminal Peptides to Form Peptide Enamides:  Synthesis of Chondriamides A and C by Wang, Xiang, Porco, John A

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Exploring Chemical Diversity of Epoxyquinoid Natural Products:  Synthesis and Biological Activity of (−)-Jesterone and Related Molecules by Hu, Yongbo, Li, Chaomin, Kulkarni, Bheemashankar A, Strobel, Gary, Lobkovsky, Emil, Torczynski, Richard M, Porco, John A

“…Enantioselective syntheses of the potent antifungal agent (−)-jesterone, its hydroxy epimer, and a dimeric quinone epoxide derivative are reported. The…”
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Total Synthesis of the NF-κB Inhibitor (−)-Cycloepoxydon:  Utilization of Tartrate-Mediated Nucleophilic Epoxidation by Li, Chaomin, Pace, Emily A, Liang, Mei-Chih, Lobkovsky, Emil, Gilmore, Thomas D, Porco, John A

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Parallel Synthesis and Purification Using Anthracene-Tagged Substrates by Wang, Xiang, Parlow, John J, Porco, John A

“…A new strategy for the synthesis and purification of synthetic intermediates is described using anthracene-tagged ester substrates in conjunction with an…”
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Analysis of 9-fluorenylmethoxycarbonyl (FMOC) loading of solid-phase synthesis resins by gas chromatography by Newcomb, William S., Deegan, Tracy L., Miller, Wendy, Porco Jr, John A.

“…Base‐catalyzed cleavage of the 9‐fluorenylmethoxycarbonyl (FMOC) group and subsequent analysis by UV spectrophotometry is commonly employed to measure the…”
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Structural and synthetic studies of the spore germination autoinhibitor, gloeosporone by Schreiber, Stuart L, Kelly, Sarah E, Porco, John A, Sammakia, Tarek, Suh, Edward M

“…Gloeosporone 1 is an autoinhibitor of spore germination that was recently isolated from conidia of Colletotrichum gloeosporioides . The structure initially…”
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Organic synthesis using chemical tags: the third Leg of parallel synthesis by Porco, Jr, J A

“…Increasing emphasis has recently been placed on the development of synthetic methods which effectively couple chemical synthesis and purification. For example,…”
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Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution by Shen, Ruichao, Porco, John A

“…A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction…”
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Polymer supports for streamlined organic synthesis by Porco Jr, John A., Labadie, Jeff W.

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Streamlined synthesis of substituted 2-Aminothiazoles using tandem precipitative and polymer-assisted reactions by Yun, Young K., Leung, Simon S. W., Porco Jr, John A.

“…The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer‐assisted transformations has…”
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Enzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling of glycosidase inhibitors by Kajimoto, Tetsuya, Liu, Kevin K. C, Pederson, Richard L, Zhong, Ziyang, Ichikawa, Yoshitaka, Porco, John A, Wong, Chi Huey

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Automated chemical synthesis: from resins to instruments by Porco, Jr, J A, Deegan, T, Devonport, W, Gooding, O W, Heisler, K, Labadie, J W, Newcomb, B, Nguyen, C, van Eikeren, P, Wong, J, Wright, P

“…Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated…”
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Chemical library synthesis using convergent approaches by Beeler, Aaron B, Schaus, Scott E, Porco, John A

“…New strategies are continuously being developed in combinatorial and diversity-oriented synthesis. Convergent design in target-oriented synthesis is commonly…”
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Transannular Diels-Alder route to systems related to dynemicin A by Porco, John A, Schoenen, Frank J, Stout, Thomas J, Clardy, Jon, Schreiber, Stuart L

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nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs by Gandin, Valentina, Masvidal, Laia, Hulea, Laura, Gravel, Simon-Pierre, Cargnello, Marie, McLaughlan, Shannon, Cai, Yutian, Balanathan, Preetika, Morita, Masahiro, Rajakumar, Arjuna, Furic, Luc, Pollak, Michael, Porco, Jr, John A, St-Pierre, Julie, Pelletier, Jerry, Larsson, Ola, Topisirovic, Ivan

“…The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation…”
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