Search Results - "Popper, Stephen"

Type I Interferon Suppresses Type II Interferon—Triggered Human Anti-Mycobacterial Responses by Teles, Rosane M. B., Graeber, Thomas G., Krutzik, Stephan R., Montoya, Dennis, Schenk, Mirjam, Lee, Delphine J., Komisopoulou, Evangelia, Kelly-Scumpia, Kindra, Chun, Rene, Iyer, Shankar S., Sarno, Euzenir N., Rea, Thomas H., Hewison, Martin, Adams, John S., Popper, Stephen J., Relman, David A., Stenger, Steffen, Bloom, Barry R., Cheng, Genhong, Modlin, Robert L.

“…Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host…”
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Dissecting interferon-induced transcriptional programs in human peripheral blood cells by Waddell, Simon J, Popper, Stephen J, Rubins, Kathleen H, Griffiths, Michael J, Brown, Patrick O, Levin, Michael, Relman, David A

“…Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex…”
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Temporal dynamics of the transcriptional response to dengue virus infection in Nicaraguan children by Popper, Stephen J, Gordon, Aubree, Liu, Minghsun, Balmaseda, Angel, Harris, Eva, Relman, David A

“…Dengue is the most prevalent mosquito-borne human illness worldwide. The ability to predict disease severity during the earliest days of the illness is a…”
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Morbidity and mortality burden of COVID-19 in rural Madagascar: results from a longitudinal cohort and nested seroprevalence study by Garchitorena, Andres, Rasoloharimanana, Lova Tsikiniaina, Rakotonanahary, Rado Jl, Evans, Michelle V, Miller, Ann C, Finnegan, Karen E, Cordier, Laura F, Cowley, Giovanna, Razafinjato, Benedicte, Randriamanambintsoa, Marius, Andrianambinina, Samuel, Popper, Stephen J, Hotahiene, Raphaël, Bonds, Matthew H, Schoenhals, Matthieu

“…Abstract Introduction Three years into the pandemic, there remains significant uncertainty about the true infection and mortality burden of COVID-19 in the…”
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Streptococcus pneumoniae nasopharyngeal colonization induces type I interferons and interferon-induced gene expression by Joyce, Elizabeth A, Popper, Stephen J, Falkow, Stanley

“…We employed DNA microarray technology to investigate the host response to Streptococcus pneumoniae in a mouse model of asymptomatic carriage. Over a period of…”
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Cathelicidin Insufficiency in Patients with Fatal Leptospirosis by Lindow, Janet C, Wunder, Jr, Elsio A, Popper, Stephen J, Min, Jin-Na, Mannam, Praveen, Srivastava, Anup, Yao, Yi, Hacker, Kathryn P, Raddassi, Khadir, Lee, Patty J, Montgomery, Ruth R, Shaw, Albert C, Hagan, Jose E, Araújo, Guilherme C, Nery, Jr, Nivison, Relman, David A, Kim, Charles C, Reis, Mitermayer G, Ko, Albert I

“…Leptospirosis causes significant morbidity and mortality worldwide; however, the role of the host immune response in disease progression and high case fatality…”
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Individuality and Variation in Gene Expression Patterns in Human Blood by Whitney, Adeline R., Diehn, Maximilian, Popper, Stephen J., Alizadeh, Ash A., Boldrick, Jennifer C., Relman, David A., Brown, Patrick O.

“…The nature and extent of interindividual and temporal variation in gene expression patterns in specific cells and tissues is an important and relatively…”
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Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue Vaccine Candidate in Non-human Primates by Strouts, Fiona R, Popper, Stephen J, Partidos, Charalambos D, Stinchcomb, Dan T, Osorio, Jorge E, Relman, David A

“…The development of a vaccine against dengue faces unique challenges, including the complexity of the immune responses to the four antigenically distinct…”
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Early Transcriptional Responses After Dengue Vaccination Mirror the Response to Natural Infection and Predict Neutralizing Antibody Titers by Popper, Stephen J, Strouts, Fiona R, Lindow, Janet C, Cheng, Henry K, Montoya, Magelda, Balmaseda, Angel, Durbin, Anna P, Whitehead, Stephen S, Harris, Eva, Kirkpatrick, Beth D, Relman, David A

“…Several promising live attenuated dengue vaccines are in development, but information about innate immune responses and early correlates of protection is…”
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Gene-expression patterns reveal underlying biological processes in Kawasaki disease by Popper, Stephen J, Shimizu, Chisato, Shike, Hiroko, Kanegaye, John T, Newburger, Jane W, Sundel, Robert P, Brown, Patrick O, Burns, Jane C, Relman, David A

“…Kawasaki disease (KD) is an acute self-limited vasculitis and the leading cause of acquired heart disease in children in developed countries. No etiologic…”
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Workshop-based learning and networking: a scalable model for research capacity strengthening in low- and middle-income countries by Perier, Celine, Nasinghe, Emmanuel, Charles, Isabelle, Ssetaba, Leoson Junior, Ahyong, Vida, Bangs, Derek, Beatty, P. Robert, Czudnochowski, Nadine, Diallo, Amy, Dugan, Eli, Fabius, Jacqueline M., Fong Baker, Hildy, Gardner, Jackson, Isaacs, Stephen, Joanah, Birungi, Kalantar, Katrina, Kateete, David, Knight, Matt, Krasilnikov, Maria, Krogan, Nevan J., Langelier, Chaz, Lee, Eric, Li, Lucy M., Licht, Daniel, Lien, Katie, Lyons, Zilose, Mboowa, Gerald, Mwebaza, Ivan, Mwesigwa, Savannah, Nalwadda, Geraldine, Nichols, Robert, Penaranda, Maria Elena, Petnic, Sarah, Phelps, Maira, Popper, Stephen J., Rape, Michael, Reingold, Arthur, Robbins, Richard, Rosenberg, Oren S., Savage, David F., Schildhauer, Samuel, Settles, Matthew L., Sserwadda, Ivan, Stanley, Sarah, Tato, Cristina M., Tsitsiklis, Alexandra, Van Dis, Erik, Vanaerschot, Manu, Vinden, Joanna, Cox, Jeffery S., Joloba, Moses L., Schaletzky, Julia

“…Science education and research have the potential to drive profound change in low- and middle-income countries (LMICs) through encouraging innovation,…”
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Gene Transcript Abundance Profiles Distinguish Kawasaki Disease from Adenovirus Infection by Popper, Stephen J., Watson, Virginia E., Shimizu, Chisato, Kanegaye, John T., Burns, Jane C., Relman, David A.

“…BackgroundAcute Kawasaki disease (KD) is difficult to distinguish from other illnesses that involve acute rash or fever, in part because the etiologic agent(s)…”
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Transcriptional Response in the Peripheral Blood of Patients Infected with Salmonella enterica Serovar Typhi by Thompson, Lucinda J., Dunstan, Sarah J., Dolecek, Christiane, Perkins, Tim, House, Deborah, Dougan, Gordon, Hue, Nguyen Thi, La, Tran Thi Phi, Du, Doan Cong, Le Thi Phuong, Dung, Nguyen Thi, Hien, Tran Tinh, Farrar, Jeremy J., Monack, Denise, Lynn, David J., Popper, Stephen J., Falkow, Stanley

“…We used microarrays and transcriptional profiling of peripheral blood to investigate the host response of 29 individuals who contracted typhoid fever in the…”
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A robust host-response-based signature distinguishes bacterial and viral infections across diverse global populations by Rao, Aditya M., Popper, Stephen J., Gupta, Sanjana, Davong, Viengmon, Vaidya, Krista, Chanthongthip, Anisone, Dittrich, Sabine, Robinson, Matthew T., Vongsouvath, Manivanh, Mayxay, Mayfong, Nawtaisong, Pruksa, Karmacharya, Biraj, Thair, Simone A., Bogoch, Isaac, Sweeney, Timothy E., Newton, Paul N., Andrews, Jason R., Relman, David A., Khatri, Purvesh

“…Limited sensitivity and specificity of current diagnostics lead to the erroneous prescription of antibiotics. Host-response-based diagnostics could address…”
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Transforming Growth Factor-β Signaling Pathway in Patients With Kawasaki Disease by Shimizu, Chisato, Jain, Sonia, Davila, Sonia, Hibberd, Martin L, Lin, Kevin O, Molkara, Delaram, Frazer, Jeffrey R, Sun, Shelly, Baker, Annette L, Newburger, Jane W, Rowley, Anne H, Shulman, Stanford T, Burgner, David, Breunis, Willemijn B, Kuijpers, Taco W, Wright, Victoria J, Levin, Michael, Eleftherohorinou, Hariklia, Coin, Lachlan, Popper, Stephen J, Relman, David A, Fury, Wen, Lin, Calvin, Mellis, Scott, Tremoulet, Adriana H, Burns, Jane C

“…BACKGROUND—Transforming growth factor (TGF)-β is a multifunctional peptide that is important in T-cell activation and cardiovascular remodeling, both of which…”
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Correction: Cathelicidin Insufficiency in Patients with Fatal Leptospirosis by Lindow, Janet C, Wunder, Jr, Elsio A, Popper, Stephen J, Min, Jin-Na, Mannam, Praveen, Srivastava, Anup, Yao, Yi, Hacker, Kathryn P, Raddassi, Khadir, Lee, Patty J, Montgomery, Ruth R, Shaw, Albert C, Hagan, Jose E, Araújo, Guilherme C, Nery, Jr, Nivison, Relman, David A, Kim, Charles C, Reis, Mitermayer G, Ko, Albert I

“…[This corrects the article DOI: 10.1371/journal.ppat.1005943.]…”
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Genomewide Analysis of the Host Response to Malaria in Kenyan Children by Griffiths, Michael J., Shafi, Mohammed J., Popper, Stephen J., Hemingway, Cheryl A., Kortok, Moses M., Wathen, Andrew, Rockett, Kirk A., Mott, Richard, Levin, Michael, Newton, Charles R., Marsh, Kevin, Relman, David A., Kwiatkowski, Dominic P.

“…Malaria is a global problem, and there is a critical need for further understanding of the disease process. When malarial parasites invade and develop within…”
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Lower Human Immunodeficiency Virus (HIV) Type 2 Viral Load Reflects the Difference in Pathogenicity of HIV-1 and HIV-2 by Popper, Stephen J., Sarr, Abdoulaye Dieng, Travers, Karin U., Guèye-Ndiaye, Aissatou, Mboup, Souleymane, Essex, Myron E., Kanki, Phyllis J.

“…Human immunodeficiency virus type 2 (HIV-2) is less pathogenic than HIV type 1 (HIV-1), but the mechanisms underlying this difference have not been defined. We…”
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Early days: genomics and human responses to infection by Liu, Minghsun, Popper, Stephen J, Rubins, Kathleen H, Relman, David A

“…DNA microarray-based gene transcript-profiling of the responses of primates to infection has begun to yield new insights into host–pathogen interactions; this…”
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Integrating Health Systems and Science to Respond to COVID-19 in a Model District of Rural Madagascar by Rakotonanahary, Rado J L, Andriambolamanana, Herinjaka, Razafinjato, Benedicte, Raza-Fanomezanjanahary, Estelle M, Ramanandraitsiory, Vero, Ralaivavikoa, Fiainamirindra, Tsirinomen'ny Aina, Andritiana, Rahajatiana, Lea, Rakotonirina, Luc, Haruna, Justin, Cordier, Laura F, Murray, Megan B, Cowley, Giovanna, Jordan, Demetrice, Krasnow, Mark A, Wright, Patricia C, Gillespie, Thomas R, Docherty, Michael, Loyd, Tara, Evans, Michelle V, Drake, John M, Ngonghala, Calistus N, Rich, Michael L, Popper, Stephen J, Miller, Ann C, Ihantamalala, Felana A, Randrianambinina, Andriamihaja, Ramiandrisoa, Bruno, Rakotozafy, Emmanuel, Rasolofomanana, Albert, Rakotozafy, Germain, Andriamahatana Vololoniaina, Manuela C, Andriamihaja, Benjamin, Garchitorena, Andres, Rakotonirina, Julio, Mayfield, Alishya, Finnegan, Karen E, Bonds, Matthew H

“…There are many outstanding questions about how to control the global COVID-19 pandemic. The information void has been especially stark in the World Health…”
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