Search Results - "Popowicz, Anthony M"

Drug-induced reactivation of apoptosis abrogates HIV-1 infection by Hanauske-Abel, Hartmut M, Saxena, Deepti, Palumbo, Paul E, Hanauske, Axel-Rainer, Luchessi, Augusto D, Cambiaghi, Tavane D, Hoque, Mainul, Spino, Michael, D'Alliessi Gandolfi, Darlene, Heller, Debra S, Singh, Sukhwinder, Park, Myung Hee, Cracchiolo, Bernadette M, Tricta, Fernando, Connelly, John, Popowicz, Anthony M, Cone, Richard A, Holland, Bart, Pe'ery, Tsafi, Mathews, Michael B

“…HIV-1 blocks apoptosis, programmed cell death, an innate defense of cells against viral invasion. However, apoptosis can be selectively reactivated in…”
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Gel filtration of dilute human embryonic hemoglobins reveals basis for their increased oxygen binding by Manning, Lois R., Popowicz, Anthony M., Padovan, Julio C., Chait, Brian T., Manning, James M.

“…This report establishes a correlation between two known properties of the human embryonic hemoglobins-- their weak subunit assemblies as demonstrated here by…”
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Intrinsic regulation of hemoglobin expression by variable subunit interface strengths by Manning, James M., Popowicz, Anthony M., Padovan, Julio C., Chait, Brian T., Manning, Lois R.

“…The expression of the six types of human Hb subunits over time is currently considered to be regulated mainly by transcription factors that bind to upstream…”
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Developmental expression of human hemoglobins mediated by maturation of their subunit interfaces by Manning, Lois R., Popowicz, Anthony M., Padovan, Julio, Chait, Brian T., Russell, J. Eric, Manning, James M.

“…Different types of human hemoglobins (Hbs) consisting of various combinations of the embryonic, fetal, and adult Hb subunits are present at certain times…”
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Energetic Differences at the Subunit Interfaces of Normal Human Hemoglobins Correlate with Their Developmental Profile by Manning, Lois R, Russell, J. Eric, Popowicz, Anthony M, Manning, Robert S, Padovan, Julio C, Manning, James M

“…A previously unrecognized function of normal human hemoglobins occurring during protein assembly is described, i.e. self-regulation of subunit pairings and…”
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The HAG mechanism: a molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases by Hanauske-Abel, Hartmut M, Popowicz, Anthony M

“…'Iron chelation' is widely understood as synonymous with non-specificity and viewed as a purely physicochemical mode of action, without any defined…”
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N‐terminal contributions of the γ‐subunit of fetal hemoglobin to its tetramer strength: Remote effects at subunit contacts by Yagami, Takeshi, Ballard, Barry T., Padovan, Julio Cesar, Chait, Brian T., Popowicz, Anthony M., Manning, James M.

“…The greatly increased tetramer strength of liganded fetal hemoglobin compared with adult hemoglobin is shown by its 70‐fold smaller tetramer‐dimer dissociation…”
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eIF5A‐controlled gene expression: A molecular concept for the anti‐cancer and anti‐HIV activity of hypusine disruptors by Hanauske‐Abel, Hartmut Martin, Cracchiolo, Bernadette M, Popowicz, Anthony M, Hanauske, Axel R

“…Mature eIF5A contains a functionally decisive hypusine residue, formed by the sequential action of deoxyhypusine synthase (DOHS) and deoxyhypusine hydroxylase…”
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Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin by Ueno, H, Popowicz, A M, Manning, J M

“…The features of random chemical modification are defined with reference to acetylation of bovine hemoglobin, which has been performed in a random manner so…”
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N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: Remote effects at subunit contacts by Yagami, T.

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Recombinant sickle hemoglobin containing a lysine substitution at Asp-85(α) : Expression in yeast, functional properties, and participation in gel formation by HIMANEN, J.-P, POPOWICZ, A. M, MANNING, J. M

“…Clinical modalities based on inhibition of gelation of HbS are hindered by the lack of quantitative information on the extent of participation of different…”
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Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities by JONES, W. M, SCALONI, A, BOSSA, F, POPOWICZ, A. M, SCHNEEWIND, O, MANNING, J. M

“…An 87% identity has been found between the reported cDNA sequence that encodes acylpeptide hydrolase (EC 3.4.19.1) [Mitta, M., Asada, K., Uchimura, Y.,…”
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Genetic Relationship Between Acylpeptide Hydrolase and Acylase, Two Hydrolytic Enzymes with Similar Binding but Different Catalytic Specifities by Jones, Wanda M., Scaloni, Andrea, Bossa, Francesco, Popowicz, Anthony M., Schneewind, Olaf, Manning, James M.

“…An 87% identity has been found between the reported cDNA sequence that encodes acylpeptide hydrolase (EC 3.4.19.1) [Mitta, M., Asada, K., Uchimura, Y.,…”
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Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines by Scaloni, A, Jones, W, Pospischil, M, Sassa, S, Schneewind, O, Popowicz, A M, Bossa, F, Graziano, S L, Manning, J M

“…During protein biosynthesis, processing of the N terminus of many proteins may occur through acetylation and deacetylation. The enzyme acylpeptide hydrolase is…”
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