Controlled drug delivery system based on ordered mesoporous silica matrices of captopril as angiotensin-converting enzyme inhibitor drug

In the present study, captopril-loaded ordered mesoporous SBA-15 silica matrix were produced, functionalized, and characterized to obtain an efficient formulation of controlled drug delivery system. First, the starting SBA-15 materials are examined to verify that their synthesis has been successful...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 100; no. 2; p. 704
Main Authors:	Popovici, R F, Seftel, E M, Mihai, G D, Popovici, E, Voicu, V A
Format:	Journal Article
Language:	English
Published:	United States 01-02-2011
Subjects:	Angiotensin-Converting Enzyme Inhibitors - administration & dosage Captopril - administration & dosage Delayed-Action Preparations - chemistry Porosity Powder Diffraction Silicon Dioxide - chemistry Spectroscopy, Fourier Transform Infrared X-Ray Diffraction
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In the present study, captopril-loaded ordered mesoporous SBA-15 silica matrix were produced, functionalized, and characterized to obtain an efficient formulation of controlled drug delivery system. First, the starting SBA-15 materials are examined to verify that their synthesis has been successful considering the structural properties, using XRD, FTIR, and BET methods. Second, the influence of processing parameters of ordered mesoporous matrices for the loading and release of captopril was investigated. The release of captopril was controlled by tailoring the surface properties of the mesoporous silica via functionalization. The loading and release kinetics (in vitro in simulated gastric and intestinal fluids) showed that both of them were affected by the surface properties of the mesoporous silica materials. Such a formulation shows potential as an efficient controlled drug delivery system.
ISSN:	1520-6017
DOI:	10.1002/jps.22308