Search Results - "Popovich, Irina G."

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice by Anisimov, Vladimir N., Zabezhinski, Mark A., Popovich, Irina G., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Rosenfeld, Svetlana V., Blagosklonny, Mikhail V

“…The nutrient-sensing TO R (target of rapamycin) pathway is involved in cellular and organismal aging. Rapamycin, an inhibitor of TO R, extends lifespan in…”
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Metformin slows down aging and extends life span of female SHR mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Tyndyk, Margarita L., Yurova, Maria V., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice by Anisimov, Vladimir N, Berstein, Lev M, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Kovalenko, Irina G, Poroshina, Tatiana E

“…Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level…”
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Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo by Anisimov, Vladimir N., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Tyndyk, Margarita L., Yurova, Maria N., Zabezhinski, Mark A., Anikin, Ivan V., Karkach, Arseniy S., Romanyukha, Alexey A.

“…Population studies have shown that treatment with the antidiabetic biguanide metformin significantly reduced cancer risk. In our animal studies, metformin…”
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Melatonin as antioxidant, geroprotector and anticarcinogen by Anisimov, Vladimir N., Popovich, Irina G., Zabezhinski, Mark A., Anisimov, Sergey V., Vesnushkin, Georgy M., Vinogradova, Irina A.

“…The effect of the pineal indole hormone melatonin on the life span of mice, rats and fruit flies has been studied using various approaches. It has been…”
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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V., Provinciali, Mauro, Re, Francesca, Franceschi, Claudio

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
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Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents by Anisimov, Vladimir N, Egorov, Maxim V, Krasilshchikova, Marina S, Lyamzaev, Konstantin G, Manskikh, Vasily N, Moshkin, Mikhail P, Novikov, Evgeny A, Popovich, Irina G, Rogovin, Konstantin A, Shabalina, Irina G, Shekarova, Olga N, Skulachev, Maxim V, Titova, Tatiana V, Vygodin, Vladimir A, Vyssokikh, Mikhail Yu, Yurova, Maria N, Zabezhinsky, Mark A, Skulachev, Vladimir P

“…The effect of the mitochondria-targeted, plastoquinone-containing antioxidant SkQ1 on the lifespan of outbred mice and of three strains of inbred mice was…”
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Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Antoch, Marina P, Blagosklonny, Mikhail V

“…Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing…”
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Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin by Popovich, Irina G, Anisimov, Vladimir N, Zabezhinski, Mark A, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Blagosklonny, Mikhail V

“…Target of Rapamycin (TOR) is involved in cellular and organismal aging. Rapamycin extends lifespan and delays cancer in mice. It is important to determine the…”
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Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models by Fedoros, Elena I., Tyndyk, Margarita L., Popovich, Irina G., Anikin, Ivan V., Yurova, Maria N., Gubareva, Ekaterina A., Pigarev, Sergey E., Panchenko, Andrey V., Solovyev, Nikolay D., Anisimov, Vladimir N.

“…A standard approach to study the anticancer activity of novel drugs is their testing in animals with inoculated tumors, which has some limitations. An…”
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Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Yurova, Maria N, Semenchenko, Anna V, Tyndyk, Margarita L, Panchenko, Andrey V, Trashkov, Alexandr P, Vasiliev, Andrey G, Khaitsev, Nikolai V

“…The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of…”
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Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens by ANISIMOV, VLADIMIR N., BERSTEIN, LEV M., POPOVICH, IRINA G., ZABEZHINSKI, MARK A., EGORMIN, PETER A., TYNDYK, MARGARITA L., ANIKIN, IVAN V., SEMENCHENKO, ANNA V., YASHIN, ANATOLI I.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice by Anisimov, Vladimir N, Piskunova, Tatiana S, Popovich, Irina G, Zabezhinski, Mark A, Tyndyk, Margarita L, Egormin, Peter A, Yurova, Maria V, Rosenfeld, Svetlana V, Semenchenko, Anna V, Kovalenko, Irina G, Poroshina, Tatiana E, Berstein, Lev M

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
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In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated by Anisimov, Vladimir N, Labunets, Irina F, Popovich, Irina G, Tyndyk, Margarita L, Yurova, Maria N, Golubev, Alexey G

“…IGF1 signaling is supposedly a key lifespan determinant in metazoans. However, controversial lifespan data were obtained with different means used to modify…”
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Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Yurova, Maria N, Tyndyk, Margarita L, Anikin, Ivan V, Egormin, Peter A, Baldueva, Irina A, Fedoros, Elena I, Pigarev, Sergey E, Panchenko, Andrey V

“…Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some…”
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Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice by Popovich, Irina G., Zabezhinski, Mark A., Panchenko, Andrei V., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Maragriata L., Yurova, Maria N., Anisimov, Vladimir N.

“…The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting…”
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Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice by Panchenko, Andrey V., Popovich, Irina G., Trashkov, Alexandr P., Egormin, Peter A., Yurova, Maria N., Tyndyk, Margarita L., Gubareva, Ekaterina A., Artyukin, Ilia N., Vasiliev, Andrey G., Khaitsev, Nikolai V., Zabezhinski, Mark A., Anisimov, Vladimir N.

“…FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death…”
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Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice by Piskunova, Tatiana S., Yurova, Maria N., Ovsyannikov, Anton I., Semenchenko, Anna V., Zabezhinski, Mark A., Popovich, Irina G., Wang, Zhao-Qi, Anisimov, Vladimir N.

“…Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death,…”
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Methods of evaluating the effect of pharmacological drugs on aging and life span in mice by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A

“…The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing…”
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Effect of exposure to light‐at‐night on life span and spontaneous carcinogenesis in female CBA mice by Anisimov, Vladimir N., Baturin, Dmitri A., Popovich, Irina G., Zabezhinski, Mark A., Manton, Kenneth G., Semenchenko, Anna V., Yashin, Anatoly I.

“…The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age…”
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