Search Results - "Popovich, I G"

Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice by Anisimov, V N, Egormin, P A, Bershtein, L M, Zabezhinskii, M A, Piskunova, T S, Popovich, I G, Semenchenko, A V

“…Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age…”
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Melatonin increases both life span and tumor incidence in female CBA mice by Anisimov, V N, Zavarzina, N Y, Zabezhinski, M A, Popovich, I G, Zimina, O A, Shtylick, A V, Arutjunyan, A V, Oparina, T I, Prokopenko, V M, Mikhalski, A I, Yashin, A I

“…From the age of 6 months until their natural deaths, female CBA mice were given melatonin with their drinking water (20 mg/l) for 5 consecutive days every…”
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Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats by ANISIMOV, V. N, POPOVICH, I. G, SHTYLIK, A. V, ZABEZHINSKI, M. A, BEN-HUH, H, GUREVICH, P, BERMAN, V, TENDLER, Y, ZUSMAN, I

“…Forty-eight two-month-old outbred female LIO rats were injected weekly with a single dose of 1,2-dimethylhydrazine (DMH; 21 mg/kg of body weight) administered…”
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Ontogenetic peculiarities of regulation of apoptosis of hypothalamic neurosecretory cells in TNF-knockout mice by Bazhanova, E. D, Pavlov, K. I, Popovich, I. G, Anisimov, V. N

“…Tumor necrosis factor (TNF) participates in regulation of many processes, including carcinogenesis and apoptosis. However, at present, there are practically no…”
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Gender Specificity of the Effect of Neonatal Melatonin Administration on Lifespan and Age-Associated Pathology in 129/Sv Mice by Yurova, M. N., Tyndyk, M. L., Popovich, I. G., Golubev, A. G., Anisimov, V. N.

“…Melatonin is subcutaneously administered in a single dose of 1.2 μg to 129/ Sv mice at days 3, 5, and 7 after birth, and the mice are observed until natural…”
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Gender-specific effects of neonatal administration of melatonin on lifespan and age-associated patholgy in 129/Sv mice. by Yurova, M N, Tyndyk, M L, Popovich, I G, Golubev, A G, Anisimov, V N

“…Melatonin was administered at the dose of 1,2 mcg per capita (an equivalent to pediatric dosages) at days 1, 3 and 5 postpartum to 129/Sv mice, which were…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence by Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Filenko, O. F., Isakova, E. F., Manskikh, V. N., Mikhelson, V. M., Panteleeva, A. A., Pasyukova, E. G., Pilipenko, D. I., Piskunova, T. S., Popovich, I. G., Roshchina, N. V., Rybina, O. Yu, Saprunova, V. B., Samoylova, T. A., Semenchenko, A. V., Skulachev, M. V., Spivak, I. M., Tsybul’ko, E. A., Tyndyk, M. L., Vyssokikh, M. Yu, Yurova, M. N., Zabezhinsky, M. A., Skulachev, V. P.

“…Very low (nano- and subnanomolar) concentrations of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (…”
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Global ageing: challenges and perspectives by Chereshnev, V.A., Khavinson, V.H., Mikhailova, O.N., Popovich, I.G., Chereshneva, M.V.

“…BIO Web of Conferences 22, 01001 (2020) Global ageing: challenges and perspectives V.A. Chereshnev1, V.H. Khavinson2, O.N. Mikhailova2*, I.G. Popovich2 and…”
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The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression by Baturin, D A, Alimova, I N, Anisimov, V N, Popovich, I G, Zabezhinski, M A, Provinciali, M, Mancini, R, Franceschi, C

“…The effect and the mechanism of light regimen and melatonin on the development of mammary tumors in HER2/neu transgenic mice were investigated. Female…”
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Inhibitory effect of melatonin on 7,12-dimethylbenz[ a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Zaripova, Elena A, Musatov, Sergey A, Andre, Véronique, Vigreux, Carole, Godard, Thierry, Sichel, François

“…Forty female CBA mice aged 3–4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1%…”
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Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats by Anisimov, Vladimir N, Khavinson, Vladimir Kh, Popovich, I G, Zabezhinski, Mark A

“…The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats. Eighty 2-month-old outbred male LIO rats…”
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Expression of werner syndrome gene in hypothalamic neurons in physiological aging by Bazhanova, E. D., Popovich, I. G., Anisimov, V. N.

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Melatonin and colon carcinogenesis : I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats by ANISIMOV, V. N, POPOVICH, I. G, ZABEZHINSKI, M. A

“…The effect of pineal indole hormone melatonin on colon carcinogenesis was firstly studied in rats. Two-month-old outbred female LIO rats were weekly exposed to…”
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Effect of epsilon-aminocaproic acid, cyclophosphamide and their combination on the growth of autochthonous sarcomas of mice induced by benzo(a)pyrene by Anikin, I V, Tyndyk, M L, Zabezhinskiĭ, M A, Popovich, I G, Anisimov, V N, Pliss, G B

“…Antifibrinolytic drug epsilon-aminocaproic acid as a therapeutic form (5% solution in saline) was tested for antitumor activity in the autochthonous…”
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Inhibitory effect of synthetic interferon inductor Cycloferone® on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by POPOVICH, I. G, ZABEZHINSKI, M. A, KOVALENKO, A. L, ANISIMOV, V. N

“…The effect of a synthetic interferon inductor Cycloferone on colon carcinogenesis was firstly studied in rats. Seventy-five 2-month-old outbred female LIO rats…”
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Models and methods for evaluating geroprotective activity of pharmacological drugs by Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G.

“…We reviewed current approaches to evaluating the efficacy and safety of potential lifespan-extending drugs (geroprotectors). We described and approved our own…”
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Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice by Rosenfeld, S V, Togo, E F, Mikheev, V S, Popovich, I G, Khavinson, V Kh, Anisimov, V N

“…The incidence of chromosome aberrations in bone marrow cells of 12-month-old SAMP-1 female mice characterized by accelerated aging was 1.8 times higher than in…”
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Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging by Popovich, I G, Zabezhinskii, M A, Anisimov, V N, Kovalenko, A L, Petrov, A Yu, Semenchenko, A V, Yashin, A I

“…Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life…”
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Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. II. Inhibitory effect of the activated carbon fiber adsorbent ‘Aqualen’ on N-methyl- N′-nitro- N-nitrosoguanidine-induced gastric carcinogenesis in rats by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Lieberman, Alexander I, Shmidt, Joseph L

“…Two-month-old female LIO rats were given N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) with tap water in a concentration of 100 mg/1 for 12 months (groups 1…”
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Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. III. Inhibitory effect of the activated carbon fiber adsorbent ‘Aqualen’ on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Berstein, Lev M, Kovalenko, Irina G, Lieberman, Alexander I, Shmidt, Joseph L

“…Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous…”
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