Ultrasound measurement of visceral fat in patients with primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is a progressive, chronic liver disease with elevated serum lipids, but it is unclear whether hyperlipidemia in PBC patients is associated with atherosclerosis. Metabolic syndrome promotes development of atherosclerotic cardiovascular disease related to abdominal type...

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Published in:	Vojnosanitetski pregled Vol. 68; no. 9; pp. 739 - 743
Main Authors:	Alempijević, Tamara, Jesić, Rada, Svorcan, Petar, Milutinović, Aleksandra Sokić, Kovacević, Nada, Radaljac, Tatjana, Popović, Dragan, Popović, Dugan Dj, Krstić, Miodrag
Format:	Journal Article
Language:	English
Published:	Serbia Military Health Department, Ministry of Defance, Serbia 01-09-2011
Subjects:	Anthropometry caradiovascular diseases Female Humans Intra-Abdominal Fat - diagnostic imaging Intra-Abdominal Fat - pathology liver cirrhosis, biliary Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - diagnostic imaging Liver Cirrhosis, Biliary - pathology Male Metabolic Syndrome - complications Middle Aged obesity risk factors Subcutaneous Fat - diagnostic imaging subcutaneous fat, abdominal Ultrasonography
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Summary:	Primary biliary cirrhosis (PBC) is a progressive, chronic liver disease with elevated serum lipids, but it is unclear whether hyperlipidemia in PBC patients is associated with atherosclerosis. Metabolic syndrome promotes development of atherosclerotic cardiovascular disease related to abdominal type obesity and insulin resistance. The aim of our study was to assess abdominal adiposity in patients with PBC. The study included 40 patients with PBC and 50 healthy controls. Age, sex and anthropometric measurements (weight, height, body mass index and waist circumference) were registered for all patients and controls. We used ultrasonography to measure subcutaneous (SF) and visceral fat (VF) diameter, subcutaneous area (SA) and visceral area (VA), as well as perirenal fat diameter (PF). Values of SF, VF and PF thicknesses in PBC patients were 19.23 +/- 5.85 mm, 10.92 +/- 3.63 mm, and 7.03 +/- 1.82 mm, respectively. In controls these measurements were 22.73 +/- 6.70 mm, 16.84 +/-5.51 mm and 10.50 +/- 2.70 mm respectively. In PBC patients SA and VA were calculated to 983.64 +/- 322.68 mm2 and 403.64 +/- 166.97 mm2 and in controls 1124.89 +/- 366.01 mm2 and 720.57 +/- 272.50 mm2 respectively. Significant difference was found for VF, VA and RF values. Considering that the amount of visceral fat plays an important role in development of metabolic syndrome and cardiovascular diseases, we concluded that the lower amount of visceral fat in PBC patients could be related to lower incidence of cardiovascular events, despite hyperlipidemia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0042-8450 2406-0720
DOI:	10.2298/VSP1109739A