Search Results - "Popova, Irina K"

Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands by Weinberg, Daniel N., Rosenbaum, Phillip, Chen, Xiao, Barrows, Douglas, Horth, Cynthia, Marunde, Matthew R., Popova, Irina K., Gillespie, Zachary B., Keogh, Michael-Christopher, Lu, Chao, Majewski, Jacek, Allis, C. David

“…Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The…”
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Structure and flexibility of the yeast NuA4 histone acetyltransferase complex by Zukin, Stefan A, Marunde, Matthew R, Popova, Irina K, Soczek, Katarzyna M, Nogales, Eva, Patel, Avinash B

“…The NuA4 protein complex acetylates histones H4 and H2A to activate both transcription and DNA repair. We report the 3.1-Å resolution cryo-electron microscopy…”
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Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions by Jain, Kanishk, Fraser, Caroline S, Marunde, Matthew R, Parker, Madison M, Sagum, Cari, Burg, Jonathan M, Hall, Nathan, Popova, Irina K, Rodriguez, Keli L, Vaidya, Anup, Krajewski, Krzysztof, Keogh, Michael-Christopher, Bedford, Mark T, Strahl, Brian D

“…Plant homeodomain (PHD) fingers are central "readers" of histone post-translational modifications (PTMs) with > 100 PHD finger-containing proteins encoded by…”
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Nucleosome conformation dictates the histone code by Marunde, Matthew R, Fuchs, Harrison A, Burg, Jonathan M, Popova, Irina K, Vaidya, Anup, Hall, Nathan W, Weinzapfel, Ellen N, Meiners, Matthew J, Watson, Rachel, Gillespie, Zachary B, Taylor, Hailey F, Mukhsinova, Laylo, Onuoha, Ugochi C, Howard, Sarah A, Novitzky, Katherine, McAnarney, Eileen T, Krajewski, Krzysztof, Cowles, Martis W, Cheek, Marcus A, Sun, Zu-Wen, Venters, Bryan J, Keogh, Michael-C, Musselman, Catherine A

“…Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized 'codes' that…”
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The dCypher Approach to Interrogate Chromatin Reader Activity Against Posttranslational Modification-Defined Histone Peptides and Nucleosomes by Marunde, Matthew R, Popova, Irina K, Weinzapfel, Ellen N, Keogh, Michael-C

“…Bulk chromatin encompasses complex sets of histone posttranslational modifications (PTMs) that recruit (or repel) the diverse reader domains of…”
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A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer by Morgan, Marc A J, Popova, Irina K, Vaidya, Anup, Burg, Jonathan M, Marunde, Matthew R, Rendleman, Emily J, Dumar, Zachary J, Watson, Rachel, Meiners, Matthew J, Howard, Sarah A, Khalatyan, Natalia, Vaughan, Robert M, Rothbart, Scott B, Keogh, Michael-C, Shilatifard, Ali

“…Mutations in the chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in expression are linked to cancer…”
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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability by Jain, Kanishk, Marunde, Matthew R, Burg, Jonathan M, Gloor, Susan L, Joseph, Faith M, Poncha, Karl F, Gillespie, Zachary B, Rodriguez, Keli L, Popova, Irina K, Hall, Nathan W, Vaidya, Anup, Howard, Sarah A, Taylor, Hailey F, Mukhsinova, Laylo, Onuoha, Ugochi C, Patteson, Emily F, Cooke, Spencer W, Taylor, Bethany C, Weinzapfel, Ellen N, Cheek, Marcus A, Meiners, Matthew J, Fox, Geoffrey C, Namitz, Kevin E W, Cowles, Martis W, Krajewski, Krzysztof, Sun, Zu-Wen, Cosgrove, Michael S, Young, Nicolas L, Keogh, Michael-Christopher, Strahl, Brian D

“…In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to…”
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Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch by Gretarsson, Kristjan H, Abini-Agbomson, Stephen, Gloor, Susan L, Weinberg, Daniel N, McCuiston, Jamie L, Kumary, Vishnu Udayakumar Sunitha, Hickman, Allison R, Sahu, Varun, Lee, Rachel, Xu, Xinjing, Lipieta, Natalie, Flashner, Samuel, Adeleke, Oluwatobi A, Popova, Irina K, Taylor, Hailey F, Noll, Kelsey, Windham, Carolina Lin, Maryanski, Danielle N, Venters, Bryan J, Nakagawa, Hiroshi, Keogh, Michael-Christopher, Armache, Karim-Jean, Lu, Chao

“…During tumor development, promoter CpG islands that are normally silenced by Polycomb repressive complexes (PRCs) become DNA-hypermethylated. The molecular…”
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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization by Dilworth, David, Hanley, Ronan P., Ferreira de Freitas, Renato, Allali-Hassani, Abdellah, Zhou, Mengqi, Mehta, Naimee, Marunde, Matthew R., Ackloo, Suzanne, Carvalho Machado, Raquel Arminda, Khalili Yazdi, Aliakbar, Owens, Dominic D. G., Vu, Victoria, Nie, David Y., Alqazzaz, Mona, Marcon, Edyta, Li, Fengling, Chau, Irene, Bolotokova, Albina, Qin, Su, Lei, Ming, Liu, Yanli, Szewczyk, Magdalena M., Dong, Aiping, Kazemzadeh, Sina, Abramyan, Tigran, Popova, Irina K., Hall, Nathan W., Meiners, Matthew J., Cheek, Marcus A., Gibson, Elisa, Kireev, Dmitri, Greenblatt, Jack F., Keogh, Michael-C., Min, Jinrong, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, James, Lindsey I., Schapira, Matthieu

“…Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark…”
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Specificity and Affinity of BPTF PHD Finger and Bromodomain in the Context of the Nucleosome by Fuchs, Harrison A., Marunde, Matthew R., Popova, Irina K., Hall, Nathan, Burg, Jonathan M., Meiners, Matt J., Gillespie, Zachary, Cheek, Marcus A., Howard, Sarah A., Sun, Zu-Wen, Morrison, Emma A., Keogh, Michael-Christopher, Musselman, Catherine A.

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