Search Results - "Poplawski, Shane G."

Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid by Chekan, Jonathan R., McKinnie, Shaun M. K., Moore, Malia L., Poplawski, Shane G., Michael, Todd P., Moore, Bradley S.

“…Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role…”
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Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis by Tudor, Jennifer C, Davis, Emily J, Peixoto, Lucia, Wimmer, Mathieu E, van Tilborg, Erik, Park, Alan J, Poplawski, Shane G, Chung, Caroline W, Havekes, Robbert, Huang, Jiayan, Gatti, Evelina, Pierre, Philippe, Abel, Ted

“…Sleep deprivation is a public health epidemic that causes wide-ranging deleterious consequences, including impaired memory and cognition. Protein synthesis in…”
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Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 by Havekes, Robbert, Park, Alan J, Tudor, Jennifer C, Luczak, Vincent G, Hansen, Rolf T, Ferri, Sarah L, Bruinenberg, Vibeke M, Poplawski, Shane G, Day, Jonathan P, Aton, Sara J, Radwańska, Kasia, Meerlo, Peter, Houslay, Miles D, Baillie, George S, Abel, Ted

“…Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been…”
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How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets by Peixoto, Lucia, Risso, Davide, Poplawski, Shane G, Wimmer, Mathieu E, Speed, Terence P, Wood, Marcelo A, Abel, Ted

“…The sequencing of the full transcriptome (RNA-seq) has become the preferred choice for the measurement of genome-wide gene expression. Despite its widespread…”
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NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors by Hawk, Joshua D, Bookout, Angie L, Poplawski, Shane G, Bridi, Morgan, Rao, Allison J, Sulewski, Michael E, Kroener, Brian T, Manglesdorf, David J, Abel, Ted

“…The formation of a long-lasting memory requires a transcription-dependent consolidation period that converts a short-term memory into a long-term memory…”
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"Gadd45b" Knockout Mice Exhibit Selective Deficits in Hippocampus-Dependent Long-Term Memory by Leach, Prescott T, Poplawski, Shane G, Kenney, Justin W, Hoffman, Barbara, Liebermann, Dan A, Abel, Ted, Gould, Thomas J

“…Growth arrest and DNA damage-inducible [beta] ("Gadd45b") has been shown to be involved in DNA demethylation and may be important for cognitive processes…”
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The CBP KIX domain regulates long-term memory and circadian activity by Chatterjee, Snehajyoti, Angelakos, Christopher C, Bahl, Ethan, Hawk, Joshua D, Gaine, Marie E, Poplawski, Shane G, Schneider-Anthony, Anne, Yadav, Manish, Porcari, Giulia S, Cassel, Jean-Christophe, Giese, K Peter, Michaelson, Jacob J, Lyons, Lisa C, Boutillier, Anne-Laurence, Abel, Ted

“…CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds…”
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Learning induces the translin/trax RNase complex to express activin receptors for persistent memory by Park, Alan Jung, Havekes, Robbert, Fu, Xiuping, Hansen, Rolf, Tudor, Jennifer C, Peixoto, Lucia, Li, Zhi, Wu, Yen-Ching, Poplawski, Shane G, Baraban, Jay M, Abel, Ted

“…Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear…”
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Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside−RNA Internal Loop Partners by Disney, Matthew D, Labuda, Lucas P, Paul, Dustin J, Poplawski, Shane G, Pushechnikov, Alexei, Tran, Tuan, Velagapudi, Sai P, Wu, Meilan, Childs-Disney, Jessica L

“…Herein is described the identification of RNA internal loops that bind to derivatives of neomycin B, neamine, tobramycin, and kanamycin A. RNA loop−ligand…”
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Characterization of a Novel Chromatin Sorting Tool Reveals Importance of Histone Variant H3.3 in Contextual Fear Memory and Motor Learning by McNally, Anna G, Poplawski, Shane G, Mayweather, Brittany A, White, Kyle M, Abel, Ted

“…The consolidation of short-term labile memories for long-term storage requires transcription and there is growing interest in defining the epigenetic…”
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A new Cannabis genome assembly associates elevated cannabidiol (CBD) with hemp introgressed into marijuana by Grassa, Christopher J., Weiblen, George D., Wenger, Jonathan P., Dabney, Clemon, Poplawski, Shane G., Timothy Motley, S., Michael, Todd P., Schwartz, C. J.

“…Summary Demand for cannabidiol (CBD), the predominant cannabinoid in hemp (Cannabis sativa), has favored cultivars producing unprecedented quantities of CBD…”
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Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid by Chekan, Jonathan R., McKinnie, Shaun M. K., Moore, Malia L., Poplawski, Shane G., Michael, Todd P., Moore, Bradley S.

“…Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role…”
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An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement by Poplawski, Shane G., Garbett, Krassimira A., McMahan, Rebekah L., Kordasiewicz, Holly B., Zhao, Hien, Kennedy, Andrew J., Goleva, Slavina B., Sanders, Teresa H., Motley, S. Timothy, Swayze, Eric E., Ecker, David J., Sweatt, J. David, Michael, Todd P., Greer, Celeste B.

“…Knockout of the memory suppressor gene histone deacetylase 2 (Hdac2) in mice elicits cognitive enhancement, and drugs that block HDAC2 have potential as…”
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Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression by Peixoto, Lucia L, Wimmer, Mathieu E, Poplawski, Shane G, Tudor, Jennifer C, Kenworthy, Charles A, Liu, Shichong, Mizuno, Keiko, Garcia, Benjamin A, Zhang, Nancy R, Giese, K, Abel, Ted

“…A fundamental question in neuroscience is how memories are stored and retrieved in the brain. Long-term memory formation requires transcription, translation…”
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Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism by Koberstein, John N, Poplawski, Shane G, Wimmer, Mathieu E, Porcari, Giulia, Kao, Charlly, Gomes, Bruce, Risso, Davide, Hakonarson, Hakon, Zhang, Nancy R, Schultz, Robert T, Abel, Ted, Peixoto, Lucia

“…Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder that is associated with genetic risk factors. Most human disease-associated…”
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Contextual fear conditioning induces differential alternative splicing by Poplawski, Shane G., Peixoto, Lucia, Porcari, Giulia S., Wimmer, Mathieu E., McNally, Anna G., Mizuno, Keiko, Giese, K. Peter, Chatterjee, Snehajyoti, Koberstein, John N., Risso, Davide, Speed, Terence P., Abel, Ted

“…•A number of genes show alternative splicing during learning.•Homer1 isoform Ania-3 is regulated by fear conditioning.•Differential isoform usage can vary with…”
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Object-location training elicits an overlapping but temporally distinct transcriptional profile from contextual fear conditioning by Poplawski, Shane G., Schoch, Hannah, Wimmer, Mathieu E., Hawk, Joshua D., Walsh, Jennifer L., Giese, Karl P., Abel, Ted

“…[Display omitted] •Microfluidic technology allows for large-scale qPCR experiments.•Object-location memory increases IEG expression similarly to fear…”
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Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling by Bridi, Morgan, Schoch, Hannah, Florian, Cédrick, Poplawski, Shane G, Banerjee, Anamika, Hawk, Joshua D, Porcari, Giulia S, Lejards, Camille, Hahn, Chang-Gyu, Giese, Karl-Peter, Havekes, Robbert, Spruston, Nelson, Abel, Ted

“…Long-term memory depends on the control of activity-dependent neuronal gene expression, which is regulated by epigenetic modifications. The epigenetic…”
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A Metabolic Murder Mystery: A Case-Based Experiment for the Undergraduate Biochemistry Laboratory by Childs-Disney, Jessica L, Kauffmann, Andrew D, Poplawski, Shane G, Lysiak, Daniel R, Stewart, Robert J, Arcadi, Jane K, Dinan, Frank J

“…In 1990, a woman was wrongly convicted of poisoning her infant son and was sentenced to life in prison. Her conviction was based on laboratory work that…”
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Using nucleosome levels, copy number alterations, and DNA methylation to profile disease state through liquid biopsy by Harrison, Sarah, Poplawski, Shane G., Orlanski, Shari, Wei, Melvin, Atteberry, Brandi, Berman, Benjamin P., Kelly, Terry

“…e15014 Background: Nucleosomes are the repeating unit of chromatin that contain important signals for proper genomic function and transcriptional activity…”
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