Search Results - "Popescu, Bogdan F"

Inflammatory Cortical Demyelination in Early Multiple Sclerosis by Lucchinetti, Claudia F, Popescu, Bogdan F.G, Bunyan, Reem F, Moll, Natalia M, Roemer, Shanu F, Lassmann, Hans, Brück, Wolfgang, Parisi, Joseph E, Scheithauer, Bernd W, Giannini, Caterina, Weigand, Stephen D, Mandrekar, Jay, Ransohoff, Richard M

“…Analysis of tissue from brain cortex obtained during biopsy of white-matter lesions in persons with early-stage multiple sclerosis suggests that cortical…”
Get full text

Meningeal and cortical grey matter pathology in multiple sclerosis by Popescu, Bogdan F Gh, Lucchinetti, Claudia F

“…Although historically considered a disease primarily affecting the white matter of the central nervous system, recent pathological and imaging studies have…”
Get full text

Association between pathological and MRI findings in multiple sclerosis by Filippi, Massimo, Prof, Rocca, Maria A, MD, Barkhof, Frederik, Prof, Brück, Wolfgang, Prof, Chen, Jacqueline T, PhD, Comi, Giancarlo, MD, DeLuca, Gabriele, MD, De Stefano, Nicola, MD, Erickson, Bradley J, PhD, Evangelou, Nikos, Prof, Fazekas, Franz, Prof, Geurts, Jeroen JG, Prof, Lucchinetti, Claudia, Prof, Miller, David H, Prof, Pelletier, Daniel, Prof, Popescu, Bogdan F Gh, PhD, Lassmann, Hans, Prof

“…Summary The identification of pathological processes that could be targeted by therapeutic interventions is a major goal of research into multiple sclerosis…”
Get full text

The Pathology of an Autoimmune Astrocytopathy: Lessons Learned from Neuromyelitis Optica by Lucchinetti, Claudia F., Guo, Yong, Popescu, Bogdan F. Gh, Fujihara, Kazuo, Itoyama, Yasuto, Misu, Tatsuro

“…Neuromyelitis optica (NMO) is a disabling autoimmune astrocytopathy characterized by typically severe and recurrent attacks of optic neuritis and…”
Get full text

Iron Heterogeneity in Early Active Multiple Sclerosis Lesions by Tham, Mylyne, Frischer, Josa M., Weigand, Stephen D., Fitz‐Gibbon, Patrick D., Webb, Samuel M., Guo, Yong, Adiele, Reginald C., Robinson, Christopher A., Brück, Wolfgang, Lassmann, Hans, Furber, Kendra L., Pushie, M. Jake, Parisi, Joseph E., Lucchinetti, Claudia F., Popescu, Bogdan F.

“…Objective Multiple sclerosis (MS) is a heterogeneous inflammatory demyelinating disease. Iron distribution is altered in MS patients' brains, suggesting iron…”
Get full text

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica by Guo, Yong, Weigand, Stephen D., Popescu, Bogdan F., Lennon, Vanda A., Parisi, Joseph E., Pittock, Sean J., Parks, Natalie E., Clardy, Stacey L., Howe, Charles L., Lucchinetti, Claudia F.

“…Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by targeting aquaporin-4 (AQP4) water channels enriched on astrocytic…”
Get full text

Intractable vomiting as the initial presentation of neuromyelitis optica by Apiwattanakul, Metha, Popescu, Bogdan F., Matiello, Marcelo, Weinshenker, Brian G., Lucchinetti, Claudia F., Lennon, Vanda A., McKeon, Andrew, Carpenter, Adam F., Miller, Gary M., Pittock, Sean J.

“…We report 12 aquaporin‐4 antibody‐positive patients (12% of seropositive Mayo Clinic patients identified since 2005) whose initial presenting symptom of…”
Get full text

Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes by Hinson, Shannon R, Romero, Michael F, Popescu, Bogdan F. Gh, Lucchinetti, Claudia F, Fryer, James P, Wolburg, Hartwig, Fallier-Becker, Petra, Noell, Susan, Lennon, Vanda A

“…The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous…”
Get full text

Pathologic heterogeneity persists in early active multiple sclerosis lesions by Metz, Imke, Weigand, Stephen D., Popescu, Bogdan F. G., Frischer, Josa M., Parisi, Joseph E., Guo, Yong, Lassmann, Hans, Brück, Wolfgang, Lucchinetti, Claudia F.

“…Objective Multiple sclerosis (MS) lesions demonstrate immunopathological heterogeneity in patterns of demyelination. Previous cross‐sectional studies reported…”
Get full text

Infrared spectral profiling of demyelinating activity in multiple sclerosis brain tissue by Gakh, Oleksandr, Wilkins, Jordan M, Guo, Yong, Popescu, Bogdan F, Weigand, Stephen D, Kalinowska-Lyszczarz, Alicja, Lucchinetti, Claudia F

“…Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. The highly dynamic nature of MS lesions has made them difficult to…”
Get full text

Neuronal RNA‐binding protein dysfunction in multiple sclerosis cortex by Salapa, Hannah E., Hutchinson, Catherine, Popescu, Bogdan F., Levin, Michael C.

“…Objective Neurodegeneration is thought to be the primary cause of neurological disability in multiple sclerosis (MS). Dysfunctional RNA‐binding proteins (RBPs)…”
Get full text

Heterogeneous Nuclear Ribonucleoprotein A1 Knockdown Alters Constituents of Nucleocytoplasmic Transport by Stang, Todd E, Salapa, Hannah E, Clarke, Joseph-Patrick W E, Popescu, Bogdan F, Levin, Michael C

“…Changes in nuclear morphology, alterations to the nuclear pore complex (NPC), including loss, aggregation, and dysfunction of nucleoporins (Nups), and…”
Get full text

Delayed nerve stimulation promotes axon-protective neurofilament phosphorylation, accelerates immune cell clearance and enhances remyelination in vivo in focally demyelinated nerves by McLean, Nikki A, Popescu, Bogdan F, Gordon, Tessa, Zochodne, Douglas W, Verge, Valerie M K

“…Rapid and efficient axon remyelination aids in restoring strong electrochemical communication with end organs and in preventing axonal degeneration often…”
Get full text

Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence by Popescu, Bogdan F Gh, George, Martin J, Bergmann, Uwe, Garachtchenko, Alex V, Kelly, Michael E, McCrea, Richard P E, Lüning, Katharina, Devon, Richard M, George, Graham N, Hanson, Akela D, Harder, Sheri M, Chapman, L Dean, Pickering, Ingrid J, Nichol, Helen

“…Rapid-scanning x-ray fluorescence (RS-XRF) is a synchrotron technology that maps multiple metals in tissues by employing unique hardware and software to…”
Get more information

Natalizumab-Associated Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis: A Postmortem Study by Wüthrich, Christian, Popescu, Bogdan F Gh, Gheuens, Sarah, Marvi, Michael, Ziman, Ronald, Denq, Stephen Pojen, Tham, Mylyne, Norton, Elizabeth, Parisi, Joseph E, Dang, Xin, Lucchinetti, Claudia F, Koralnik, Igor J

“…ABSTRACTNatalizumab, a monoclonal antibody directed against α4 integrins, has, to date, been associated with 399 cases of progressive multifocal…”
Get full text

Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions by Popescu, Bogdan F.G, Guo, Yong, Jentoft, Mark E, Parisi, Joseph E, Lennon, Vanda A, Pittock, Sean J, Weinshenker, Brian G, Wingerchuk, Dean M, Giannini, Caterina, Metz, Imke, Brück, Wolfgang, Shuster, Elizabeth A, Carter, Jonathan, Boyd, Clara D, Clardy, Stacey Lynn, Cohen, Bruce A, Lucchinetti, Claudia F

“…OBJECTIVE:To assess, in a surgical biopsy cohort of active demyelinating lesions, the diagnostic utility of aquaporin-4 (AQP4) immunohistochemistry in…”
Get full text

Iron, Copper, and Zinc Distribution of the Cerebellum by Popescu, Bogdan F. Gh, Robinson, Christopher A., Rajput, Alex, Rajput, Ali H., Harder, Sheri L., Nichol, Helen

“…Synchrotron rapid-scanning X-ray fluorescence (RS-XRF) is employed for the first time to simultaneously map iron, copper, and zinc in the normal cerebellum…”
Get full text

Evidence of aquaporin involvement in human central pontine myelinolysis by Popescu, Bogdan F Gh, Bunyan, Reem F, Guo, Yong, Parisi, Joseph E, Lennon, Vanda A, Lucchinetti, Claudia F

“…Central pontine myelinolysis (CPM) is a demyelinating disorder of the central basis pontis that is often associated with osmotic stress. The aquaporin water…”
Get full text

Pathology of demyelinating diseases by Popescu, Bogdan F Gh, Lucchinetti, Claudia F

“…There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases…”
Get full text

RNA Binding Protein Dysfunction Links Smoldering/Slowly Expanding Lesions to Neurodegeneration in Multiple Sclerosis by Messmer, Miranda L, Salapa, Hannah E, Popescu, Bogdan F, Levin, Michael C

“…Despite the advances in treatments for multiple sclerosis (MS), unremitting neurodegeneration continues to drive disability and disease progression…”
Get full text