Search Results - "Pope, W. B."

MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy by POPE, W. B, LAI, A, NGHIEMPHU, P, MISCHEL, P, CLOUGHESY, T. F

“…Patients with recurrent gliomas (n = 14) were treated with bevacizumab and carboplatin, cpt-11, or etoposide. Follow-up MRI scans were obtained 2 to 6 weeks…”
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Relationship between Tumor Enhancement, Edema, IDH1 Mutational Status, MGMT Promoter Methylation, and Survival in Glioblastoma by CARRILLO, J. A, LAI, A, CLOUGHESY, T. F, POPE, W. B, NGHIEMPHU, P. L, KIM, H. J, PHILLIPS, H. S, KHARBANDA, S, MOFTAKHAR, P, LALAEZARI, S, YONG, W, ELLINGSON, B. M

“…Both IDH1 mutation and MGMT promoter methylation are associated with longer survival. We investigated the ability of imaging correlates to serve as noninvasive…”
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Bevacizumab and chemotherapy for recurrent glioblastoma : A single-institution experience by NGHIEMPHU, P. L, LIU, W, NELSON, S. F, ELASHOFF, R, CLOUGHESY, T. F, LEE, Y, THAN, T, GRAHAM, C, LAI, A, GREEN, R. M, POPE, W. B, LIAU, L. M, MISCHEL, P. S

“…Bevacizumab has been shown to be effective in the treatment of recurrent glioblastoma in combination with chemotherapy compared with historic controls but not…”
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Apparent Diffusion Coefficient Histogram Analysis Stratifies Progression-Free Survival in Newly Diagnosed Bevacizumab-Treated Glioblastoma by POPE, W. B, LAI, A, TRAN, A, CLOUGHESY, T. F, MEHTA, R, KIM, H. J, QIAO, J, YOUNG, J. R, XUE, X, GOLDIN, J, BROWN, M. S, NGHIEMPHU, P. L

“…Currently it is difficult to predict tumor response to anti-angiogenic therapy in individual patients. Our aim was to determine if ADC histogram analysis can…”
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Persistent Diffusion-Restricted Lesions in Bevacizumab-Treated Malignant Gliomas Are Associated with Improved Survival Compared with Matched Controls by MONG, S, ELLINGSON, B. M, NGHIEMPHU, P. L, KIM, H. J, MIRSADRAEI, L, LAI, A, YONG, W, ZAW, T. M, CLOUGHESY, T. F, POPE, W. B

“…A subset of patients with malignant glioma develops conspicuous lesions characterized by persistent restricted diffusion during treatment with bevacizumab. The…”
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Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab by POPE, W. B, XIA, Q, PATON, V. E, DAS, A, HAMBLETON, J, KIM, H. J, HUO, J, BROWN, M. S, GOLDIN, J, CLOUGHESY, T

“…We evaluated patterns of tumor progression in patients with recurrent glioblastoma who were treated with bevacizumab (BEV) alone or in combination with…”
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Differential Gene Expression in Glioblastoma Defined by ADC Histogram Analysis: Relationship to Extracellular Matrix Molecules and Survival by POPE, W. B, MIRSADRAEI, L, NELSON, S. F, YONG, W, PHILLIPS, H. S, CLOUGHESY, T. F, LAI, A, ESKIN, A, QIAO, J, KIM, H. J, ELLINGSON, B, NGHIEMPHU, P. L, KHARBANDA, S, SORIANO, R. H

“…ADC histogram analysis can stratify outcomes in patients with GBM treated with bevacizumab. Therefore, we compared gene expression between high-versus-low ADC…”
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Characterizing Brain Tumor Research: The Role of the National Institutes of Health by POPE, W. B, ITAGAKI, M. W

“…The contribution of radiology to brain tumor research is unknown. We sought to determine how the proportion of neuro-oncologic publications generated by…”
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Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol by Young, J R, Pope, W B, Bobinski, M

“…Our aim was to evaluate whether serial administration of the macrocyclic gadolinium-based contrast agent gadoteridol in children is associated with T1-weighted…”
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Blood-Labyrinth Barrier Permeability in Menière Disease and Idiopathic Sudden Sensorineural Hearing Loss: Findings on Delayed Postcontrast 3D-FLAIR MRI by Pakdaman, M N, Ishiyama, G, Ishiyama, A, Peng, K A, Kim, H J, Pope, W B, Sepahdari, A R

“…Menière disease and idiopathic sudden sensorineural hearing loss can have overlapping clinical presentation and may have similar pathophysiology. Prior studies…”
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Probabilistic radiographic atlas of glioblastoma phenotypes by Ellingson, B M, Lai, A, Harris, R J, Selfridge, J M, Yong, W H, Das, K, Pope, W B, Nghiemphu, P L, Vinters, H V, Liau, L M, Mischel, P S, Cloughesy, T F

“…Tumor location is a significant prognostic factor in glioblastoma, which may reflect the genetic profile of tumor precursor cells. The purpose of the current…”
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Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange by Leu, K, Boxerman, J L, Cloughesy, T F, Lai, A, Nghiemphu, P L, Liau, L M, Pope, W B, Ellingson, B M

“…Contrast agent extravasation through a disrupted blood-brain barrier potentiates inaccurate DSC MR imaging estimation of relative CBV. We explored whether…”
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Association between Tumor Acidity and Hypervascularity in Human Gliomas Using pH-Weighted Amine Chemical Exchange Saturation Transfer Echo-Planar Imaging and Dynamic Susceptibility Contrast Perfusion MRI at 3T by Wang, Y-L, Yao, J, Chakhoyan, A, Raymond, C, Salamon, N, Liau, L M, Nghiemphu, P L, Lai, A, Pope, W B, Nguyen, N, Ji, M, Cloughesy, T F, Ellingson, B M

“…Acidification of the tumor microenvironment from abnormal metabolism along with angiogenesis to meet metabolic demands are both hallmarks of malignant brain…”
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Pretreatment ADC histogram analysis is a predictive imaging biomarker for bevacizumab treatment but not chemotherapy in recurrent glioblastoma by Ellingson, B M, Sahebjam, S, Kim, H J, Pope, W B, Harris, R J, Woodworth, D C, Lai, A, Nghiemphu, P L, Mason, W P, Cloughesy, T F

“…Pre-treatment ADC characteristics have been shown to predict response to bevacizumab in recurrent glioblastoma multiforme. However, no studies have examined…”
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Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging by Chakhoyan, A, Leu, K, Pope, W B, Cloughesy, T F, Ellingson, B M

“…DSC perfusion MR imaging in brain tumors requires a trade-off between spatial and temporal resolution, resulting in less spatial coverage to meet the temporal…”
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Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry by Tran, Anh N, Lai, Albert, Li, Sichen, Pope, Whitney B, Teixeira, Stephanie, Harris, Robert J, Woodworth, Davis C, Nghiemphu, Phioanh L, Cloughesy, Timothy F, Ellingson, Benjamin M

“…Isocitrate dehydrogenase 1 (IDH1) mutations have been linked to favorable outcomes in patients with glioblastoma multiforme (GBM). Recent in vitro experiments…”
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Response assessment in neuro-oncology criteria: implementation challenges in multicenter neuro-oncology trials by Pope, W B, Hessel, C

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Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration by Young, J.R., Orosz, I., Franke, M.A., Kim, H.J., Woodworth, D., Ellingson, B.M., Salamon, N., Pope, W.B.

“…To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted…”
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Arterial spin-labeling perfusion MRI stratifies progression-free survival and correlates with epidermal growth factor receptor status in glioblastoma by Qiao, X J, Ellingson, B M, Kim, H J, Wang, D J J, Salamon, N, Linetsky, M, Sepahdari, A R, Jiang, B, Tian, J J, Esswein, S R, Cloughesy, T F, Lai, A, Nghiemphu, L, Pope, W B

“…Glioblastoma is a common primary brain tumor with a poor but variable prognosis. Our aim was to investigate the feasibility of MR perfusion imaging by using…”
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Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y by Pope, W B, Lambert, M P, Leypold, B, Seupaul, R, Sletten, L, Krafft, G, Klein, W L

“…A phosphorylated tau epitope specific for paired helical filaments in Alzheimer's disease is recognized by monoclonal antibody PHF-1. Healthy adult brains lack…”
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