Search Results - "Pope, George R."

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis by O'Carroll, Anne-Marie, Lolait, Stephen J, Harris, Louise E, Pope, George R

“…The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate…”
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Agonist-induced internalization and desensitization of the apelin receptor by Pope, George R., Tilve, Sharada, McArdle, Craig A., Lolait, Stephen J., O'Carroll, Anne-Marie

“…Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR)…”
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Abnormal fluid homeostasis in apelin receptor knockout mice by Roberts, Emma M, Newson, Michael J F, Pope, George R, Landgraf, Rainer, Lolait, Stephen J, O'Carroll, Anne-Marie

“…The apelinergic system, comprised of apelin and its G protein-coupled receptor (APJ; APLNR as given in MGI Database), is expressed within key regions of the…”
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G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis by Hazell, Georgina G.J, Hindmarch, Charles C, Pope, George R, Roper, James A, Lightman, Stafford L, Murphy, David, O’Carroll, Anne-Marie, Lolait, Stephen J

“…Graphical abstract Highlights ► The paraventricular and supraoptic nuclei of the hypothalamus are regulators of homeostasis. ► Over one hundred G…”
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The effects of apelin on hypothalamic–pituitary–adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms by Newson, Michael J F, Roberts, Emma M, Pope, George R, Lolait, Stephen J, O'Carroll, Anne-Marie

“…The apelinergic system has a widespread expression in the central nervous system (CNS) including the paraventricular nucleus, supraoptic nucleus and median…”
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Tuning T‐Cell Receptor Affinity to Optimize Clinical Risk‐Benefit When Targeting Alpha‐Fetoprotein–Positive Liver Cancer by Docta, Roslin Y., Ferronha, Tiago, Sanderson, Joseph P., Weissensteiner, Thomas, Pope, George R., Bennett, Alan D., Pumphrey, Nicholas J., Ferjentsik, Zoltan, Quinn, Laura L., Wiedermann, Guy E., Anderson, Victoria E., Saini, Manoj, Maroto, Miguel, Norry, Elliot, Gerry, Andrew B.

“…Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic options. Alpha‐fetoprotein (AFP) is often expressed at high levels…”
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Central and peripheral apelin receptor distribution in the mouse: Species differences with rat by Pope, George R., Roberts, Emma M., Lolait, Stephen J., O’Carroll, Anne-Marie

“…► APJ is well characterized in the rat but is not well described in mouse tissues. ► We show the first detailed anatomical distribution of APJ mRNA and protein…”
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Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling: EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)-MEDIATED FEEDBACK LOOPS CONTROL HORMONE SENSING by Garner, Kathryn L, Perrett, Rebecca M, Voliotis, Margaritis, Bowsher, Clive, Pope, George R, Pham, Thanh, Caunt, Christopher J, Tsaneva-Atanasova, Krasimira, McArdle, Craig A

“…Cell signaling pathways are noisy communication channels, and statistical measures derived from information theory can be used to quantify the information they…”
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Enhancing Efficacy of TCR-engineered CD4 + T Cells Via Coexpression of CD8α by Anderson, Victoria E., Brilha, Sara S., Weber, Anika M., Pachnio, Annette, Wiedermann, Guy E., Dauleh, Sumaya, Ahmed, Tina, Pope, George R., Quinn, Laura L., Docta, Roslin Y., Quattrini, Adriano, Masters, Siobhan, Cartwright, Neil, Viswanathan, Preetha, Melchiori, Luca, Rice, Louise V., Sevko, Alexandra, Gueguen, Claire, Saini, Manoj, Tavano, Barbara, Abbott, Rachel J.M., Silk, Jonathan D., Laugel, Bruno, Sanderson, Joseph P., Gerry, Andrew B.

“…Adoptive cell therapy with T cells expressing affinity-enhanced T-cell receptors (TCRs) is a promising treatment for solid tumors. Efforts are ongoing to…”
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Pulsatile hormonal signaling to extracellular signal-regulated kinase: exploring system sensitivity to gonadotropin-releasing hormone pulse frequency and width by Perrett, Rebecca M, Voliotis, Margaritis, Armstrong, Stephen P, Fowkes, Robert C, Pope, George R, Tsaneva-Atanasova, Krasimira, McArdle, Craig A

“…Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate…”
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Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling by Garner, Kathryn L., Perrett, Rebecca M., Voliotis, Margaritis, Bowsher, Clive, Pope, George R., Pham, Thanh, Caunt, Christopher J., Tsaneva-Atanasova, Krasimira, McArdle, Craig A.

“…Cell signaling pathways are noisy communication channels, and statistical measures derived from information theory can be used to quantify the information they…”
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Enhancing Efficacy of TCR-engineered CD4+ T Cells Via Coexpression of CD8α by Anderson, Victoria E., Brilha, Sara S., Weber, Anika M., Pachnio, Annette, Wiedermann, Guy E., Dauleh, Sumaya, Ahmed, Tina, Pope, George R., Quinn, Laura L., Docta, Roslin Y., Quattrini, Adriano, Masters, Siobhan, Cartwright, Neil, Viswanathan, Preetha, Melchiori, Luca, Rice, Louise V., Sevko, Alexandra, Gueguen, Claire, Saini, Manoj, Tavano, Barbara, Abbott, Rachel J.M., Silk, Jonathan D., Laugel, Bruno, Sanderson, Joseph P., Gerry, Andrew B.

“…Adoptive cell therapy with T cells expressing affinity-enhanced T-cell receptors (TCRs) is a promising treatment for solid tumors. Efforts are ongoing to…”
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Pulsatile Hormonal Signaling to Extracellular Signal-regulated Kinase by Perrett, Rebecca M., Voliotis, Margaritis, Armstrong, Stephen P., Fowkes, Robert C., Pope, George R., Tsaneva-Atanasova, Krasimira, McArdle, Craig A.

“…Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate…”
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