Search Results - "Popadyuk, Irina I."

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 by Salomatina, Oksana V, Dyrkheeva, Nadezhda S, Popadyuk, Irina I, Zakharenko, Alexandra L, Ilina, Ekaterina S, Komarova, Nina I, Reynisson, Jóhannes, Salakhutdinov, Nariman F, Lavrik, Olga I, Volcho, Konstantin P

“…A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and…”
Get full text

Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O -Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo by Markov, Andrey V, Sen'kova, Aleksandra V, Popadyuk, Irina I, Salomatina, Oksana V, Logashenko, Evgeniya B, Komarova, Nina I, Ilyina, Anna A, Salakhutdinov, Nariman F, Zenkova, Marina A

“…A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3'-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1',2',4'-oxadiazole moieties at the C-30…”
Get full text

Novel Derivatives of Deoxycholic Acid Bearing Linear Aliphatic Diamine and Aminoalcohol Moieties and their Cyclic Analogs at the C3 Position: Synthesis and Evaluation of Their In Vitro Antitumor Potential by Markov, Andrey V, Babich, Valeriya O, Popadyuk, Irina I, Salomatina, Oksana V, Logashenko, Evgeniya B, Salakhutdinov, Nariman F, Zenkova, Marina A

“…A series of novel deoxycholic acid (DCA) derivatives containing aliphatic diamine and aminoalcohol or morpholine moieties at the C3 position were synthesized…”
Get full text

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors by Salomatina, Oksana V, Popadyuk, Irina I, Zakharenko, Alexandra L, Zakharova, Olga D, Fadeev, Dmitriy S, Komarova, Nina I, Reynisson, Jóhannes, Arabshahi, H John, Chand, Raina, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…An Important task in the treatment of oncological and neurodegenerative diseases is the search for new inhibitors of DNA repair system enzymes. Tyrosyl-DNA…”
Get full text

Novel O-acylated amidoximes and substituted 1,2,4-oxadiazoles synthesised from (+)-ketopinic acid possessing potent virus-inhibiting activity against phylogenetically distinct influenza A viruses by Chernyshov, Vladimir V., Yarovaya, Olga I., Esaulkova, Iana L., Sinegubova, Ekaterina, Borisevich, Sophia S., Popadyuk, Irina I., Zarubaev, Vladimir V., Salakhutdinov, Nariman F.

“…[Display omitted] This article describes the synthesis and antiviral activity evaluation of new substituted 1,2,4-oxadiazoles containing a bicyclic substituent…”
Get full text

Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study by Salomatina, Oksana V., Popadyuk, Irina I., Zakharenko, Alexandra L., Zakharova, Olga D., Chepanova, Arina A., Dyrkheeva, Nadezhda.S., Komarova, Nina I., Reynisson, Jóhannes, Anarbaev, Rashid O., Salakhutdinov, Nariman F., Lavrik, Olga I., Volcho, Konstantin P.

“…[Display omitted] •para-Bromoanilides of deoxycholic acid derivatives were designed and synthesized.•All target compounds were evaluated as inhibitors of…”
Get full text

Nitrogen-Containing Heterocyclic Compounds Obtained from Monoterpenes or Their Derivatives: Synthesis and Properties by Chernyshov, Vladimir V., Popadyuk, Irina I., Yarovaya, Olga I., Salakhutdinov, Nariman F.

“…Directed transformation of available natural compounds with native biological activity is a promising area of research in organic and medicinal chemistry aimed…”
Get full text

Synthesis and biological activity of novel deoxycholic acid derivatives by Popadyuk, Irina I., Markov, Andrey V., Salomatina, Oksana V., Logashenko, Evgeniya B., Shernyukov, Andrey V., Zenkova, Marina A., Salakhutdinov, Nariman F.

“…[Display omitted] We report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring deoxycholic acid (DCA) bearing…”
Get full text

Novel derivatives of deoxycholic acid bearing aliphatic or cyclic diamine moieties at the C-3 position: Synthesis and evaluation of anti-proliferative activity by Popadyuk, Irina I., Markov, Andrey V., Babich, Valeriya O., Salomatina, Oksana V., Logashenko, Evgeniya B., Zenkova, Marina A., Salakhutdinov, Nariman F.

“…[Display omitted] A new library of deoxycholic acid derivatives bearing nitrogen-containing moieties at the C-3 position was synthesised from epoxy derivative…”
Get full text

Synthesis and evaluation of antitumor, anti-inflammatory and analgesic activity of novel deoxycholic acid derivatives bearing aryl- or hetarylsulfanyl moieties at the C-3 position by Popadyuk, Irina I., Markov, Andrey V., Morozova, Ekaterina A., Babich, Valeriya O., Salomatina, Oksana V., Logashenko, Evgeniya B., Zenkova, Marina A., Tolstikova, Tat'yana G., Salakhutdinov, Nariman F.

“…[Display omitted] •Formation of C-3β-epoxy derivatives of DCA with high stereoselectivity.•Synthesis of new DCA derivatives via an epoxide ring opening…”
Get full text