Search Results - "Poot, Alex"

Fluorine-18 labelled building blocks for PET tracer synthesis by van der Born, Dion, Pees, Anna, Poot, Alex J, Orru, Romano V A, Windhorst, Albert D, Vugts, Danielle J

“…Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a…”
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[18F]mFBG PET/CT imaging outperforms MRI and [68 Ga]Ga-DOTA-TOC PET/CT in identifying recurrence pheochromocytoma by Suurd, Diederik P. D., Poot, Alex J., van Leeuwaarde, Rachel S., Windhorst, Albert D., Vriens, Menno R., de Keizer, Bart

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In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors by Salamanca-Cardona, Lucia, Shah, Hardik, Poot, Alex J., Correa, Fabian M., Di Gialleonardo, Valentina, Lui, Hui, Miloushev, Vesselin Z., Granlund, Kristin L., Tee, Sui S., Cross, Justin R., Thompson, Craig B., Keshari, Kayvan R.

“…The oncometabolite 2-hydroxyglutarate (2-HG) is a signature biomarker in various cancers, where it accumulates as a result of mutations in isocitrate…”
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[18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study by Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J. A. T., Viol, Sebastiaan L. Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G. E. H., Tytgat, Godelieve A. M., de Keizer, Bart

“…  Purpose Meta -[ 18 F]fluorobenzylguanidine ([ 18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging…”
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Comparison of the octadentate bifunctional chelator DFO-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET by Vugts, Danielle J., Klaver, Chris, Sewing, Claudia, Poot, Alex J., Adamzek, Kevin, Huegli, Seraina, Mari, Cristina, Visser, Gerard W. M., Valverde, Ibai E., Gasser, Gilles, Mindt, Thomas L., van Dongen, Guus A. M. S.

“…Purpose All clinical 89 Zr-immuno-PET studies are currently performed with the chelator desferrioxamine (DFO). This chelator provides hexadentate coordination…”
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Hyperpolarized [5- 13 C,4,4- 2 H 2 ,5- 15 N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine by Eskandari, Roozbeh, Kim, Nathaniel, Mamakhanyan, Arsen, Saoi, Michelle, Zhang, Guannan, Berisaj, Marjan, Granlund, Kristin L, Poot, Alex J, Cross, Justin, Thompson, Craig B, Keshari, Kayvan R

“…Glutamine is consumed by rapidly proliferating cells and can provide the carbon and nitrogen required for growth through various metabolic pathways. However,…”
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The Development of Positron Emission Tomography Tracers for In Vivo Targeting the Kinase Domain of the Epidermal Growth Factor Receptor by Högnäsbacka, Antonia, Poot, Alex J, Vugts, Danielle J, van Dongen, Guus A M S, Windhorst, Albert D

“…Multiple small molecule PET tracers have been developed for the imaging of the epidermal growth factor receptor (EGFR). These tracers target the tyrosine…”
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[ 68 Ga]Ga-RAYZ-8009: A Glypican-3-Targeted Diagnostic Radiopharmaceutical for Hepatocellular Carcinoma Molecular Imaging-A First-in-Human Case Series by Poot, Alex J, Lapa, Constantin, Weber, Wolfgang A, Lam, Marnix G E H, Eiber, Matthias, Dierks, Alexander, Bundschuh, Ralph A, Braat, Arthur J A T

“…To date, the imaging and diagnosis of hepatocellular carcinoma (HCC) rely on CT/MRI, which have well-known limitations. Glypican-3 (GPC3) is a cell surface…”
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From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application by Pekošak, Aleksandra, Filp, Ulrike, Poot, Alex J., Windhorst, Albert D.

“…Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as well as enzyme substrates…”
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In vivo imaging of TGFβ signalling components using positron emission tomography by Rotteveel, Lonneke, Poot, Alex J., Bogaard, Harm Jan, ten Dijke, Peter, Lammertsma, Adriaan A., Windhorst, Albert D.

“…•The transforming growth factor β (TGFβ) pathway is important in disease.•Imaging the TGFβ pathway is vital for understanding its role in disease.•An overview…”
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Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry by Earley, Daniel F., Guillou, Amaury, van der Born, Dion, Poot, Alex J., Holland, Jason P.

“…89Zr-radiolabelled proteins functionalised with desferrioxamine B are a cornerstone of diagnostic positron emission tomography. In the clinical setting,…”
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Sentinel lymph node detection in thyroid carcinoma using [68Ga]Ga-tilmanocept PET/CT: a proof-of-concept study by de Vries, Lisa H., Lodewijk, Lutske, Ververs, Tessa, Poot, Alex J., van Rooij, Rob, Brosens, Lodewijk A. A., de Krijger, Ronald R., Rinkes, Inne H. M. Borel, Vriens, Menno R., de Keizer, Bart

“…Purpose Sentinel lymph node (SLN) biopsy is rarely used for thyroid carcinoma staging. This is due to challenges associated with conventional Tc-99m-labeled…”
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The Current Status and Future Potential of Theranostics to Diagnose and Treat Childhood Cancer by Poot, Alex J, Lam, Marnix G E H, van Noesel, Max M

“…In theranostics (i.e., therapy and diagnostics) radiopharmaceuticals are used for both therapeutic and diagnostic purposes by targeting one specific tumor…”
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Stereocontrolled [11C]Alkylation of N‐Terminal Glycine Schiff Bases To Obtain Dipeptides by Filp, Ulrike, Pekošak, Aleksandra, Poot, Alex J., Windhorst, Albert D.

“…The use of various quaternary ammonium salts as chiral phase‐transfer catalysts allowed effective and stereoselective radiochemical [11C]alkylation to obtain…”
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Identifying advanced stage NSCLC patients who benefit from afatinib therapy using 18F-afatinib PET/CT imaging by van de Stadt, Eveline A., Yaqub, Maqsood, Lammertsma, Adriaan A., Poot, Alex J., Schuit, Robert C., Remmelzwaal, Sharon, Schwarte, Lothar A., Smit, Egbert F., Hendrikse, Harry, Bahce, Idris

“…•18F-afatinib PET/CT is a safe tool to quantify 18F-afatinib uptake in NSCLC tumors.•Tumor uptake of 18F-afatinib is higher in EGFR mutated NSCLC versus wild…”
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Evaluating the Targeting of a Staphylococcus-aureus -Infected Implant with a Radiolabeled Antibody In Vivo by van Dijk, Bruce, Hooning van Duyvenbode, J Fred F, de Vor, Lisanne, Nurmohamed, F Ruben H A, Lam, Marnix G E H, Poot, Alex J, Ramakers, Ruud M, Koustoulidou, Sofia, Beekman, Freek J, van Strijp, Jos, Rooijakkers, Suzan H M, Dadachova, Ekaterina, Vogely, H Charles, Weinans, Harrie, van der Wal, Bart C H

“…Implant infections caused by are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative…”
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Synthesis and preclinical evaluation of two osimertinib isotopologues labeled with carbon-11 as PET tracers targeting the tyrosine kinase domain of the epidermal growth factor receptor by Högnäsbacka, Antonia, Poot, Alex J., Kooijman, Esther, Schuit, Robert C., Schreurs, Maxime, Verlaan, Mariska, van den Hoek, Johan, Heideman, Daniëlle A.M., Beaino, Wissam, van Dongen, Guus A.M.S., Vugts, Danielle J., Windhorst, Albert D.

“…Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) that is able to inhibit the EGFR treatment resistance mutation T790M and primary EGFR…”
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Correction to: [18F]mFBG PET‑CT for detection and localisation of neuroblastoma: a prospective pilot study by Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J. A. T., Viol, Sebastiaan L. Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G. E. H., Tytgat, Godelieve A. M., de Keizer, Bart

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PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET by Slobbe, Paul, Poot, Alex J., Windhorst, Albert D., van Dongen, Guus A.M.S.

“…► Radiolabeling of TKIs. ► PET imaging of TKIs in drug development. ► TKI-PET as tool for personalized therapy. The discovery and increased understanding of…”
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Design, Synthesis, Radiosynthesis and Biological Evaluation of Fenretinide Analogues as Anticancer and Metabolic Syndrome‐Preventive Agents by Patruno, Ilaria, Thompson, Dawn, Dall'Angelo, Sergio, Windhorst, Albert D., Vugts, Danielle J., Poot, Alex J., Mody, Nimesh, Zanda, Matteo

“…Fenretinide (4‐HPR) is a synthetic derivative of all‐trans‐retinoic acid (ATRA) characterised by improved therapeutic properties and toxicological profile…”
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