Search Results - "Poore, Gregory"

The microbiome and human cancer by Sepich-Poore, Gregory D, Zitvogel, Laurence, Straussman, Ravid, Hasty, Jeff, Wargo, Jennifer A, Knight, Rob

“…Microbial roles in cancer formation, diagnosis, prognosis, and treatment have been disputed for centuries. Recent studies have provocatively claimed that…”
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Microbiome analyses of blood and tissues suggest cancer diagnostic approach by Poore, Gregory D, Kopylova, Evguenia, Zhu, Qiyun, Carpenter, Carolina, Fraraccio, Serena, Wandro, Stephen, Kosciolek, Tomasz, Janssen, Stefan, Metcalf, Jessica, Song, Se Jin, Kanbar, Jad, Miller-Montgomery, Sandrine, Heaton, Robert, Mckay, Rana, Patel, Sandip Pravin, Swafford, Austin D, Knight, Rob

“…Systematic characterization of the cancer microbiome provides the opportunity to develop techniques that exploit non-human, microorganism-derived molecules in…”
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Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions by Narunsky-Haziza, Lian, Sepich-Poore, Gregory D, Livyatan, Ilana, Asraf, Omer, Martino, Cameron, Nejman, Deborah, Gavert, Nancy, Stajich, Jason E, Amit, Guy, González, Antonio, Wandro, Stephen, Perry, Gili, Ariel, Ruthie, Meltser, Arnon, Shaffer, Justin P, Zhu, Qiyun, Balint-Lahat, Nora, Barshack, Iris, Dadiani, Maya, Gal-Yam, Einav N, Patel, Sandip Pravin, Bashan, Amir, Swafford, Austin D, Pilpel, Yitzhak, Knight, Rob, Straussman, Ravid

“…Cancer-microbe associations have been explored for centuries, but cancer-associated fungi have rarely been examined. Here, we comprehensively characterize the…”
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Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans by Ha, Connie W.Y., Martin, Anthony, Sepich-Poore, Gregory D., Shi, Baochen, Wang, Yizhou, Gouin, Kenneth, Humphrey, Gregory, Sanders, Karenina, Ratnayake, Yasiru, Chan, Kelvin S.L., Hendrick, Gustaf, Caldera, J.R., Arias, Christian, Moskowitz, Jacob E., Ho Sui, Shannan J., Yang, Shaohong, Underhill, David, Brady, Matthew J., Knott, Simon, Kaihara, Kelly, Steinbaugh, Michael J., Li, Huiying, McGovern, Dermot P.B., Knight, Rob, Fleshner, Phillip, Devkota, Suzanne

“…A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue…”
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Intratumoral bacteria generate a new class of therapeutically relevant tumor antigens in melanoma by Sepich-Poore, Gregory D., Carter, Hannah, Knight, Rob

“…The functional repertoire of intratumoral microorganisms and their local effects on the host remain poorly characterized. By revealing potentially immunogenic…”
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Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process: Humans and their tumors are not aseptic, and the multispecies nature of cancer modulates clinical care and clonal evolution by Sepich‐Poore, Gregory D., Guccione, Caitlin, Laplane, Lucie, Pradeu, Thomas, Curtius, Kit, Knight, Rob

“…Abstract The presence and role of microbes in human cancers has come full circle in the last century. Tumors are no longer considered aseptic, but implications…”
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Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures by Wozniak, Jacob M., Mills, Robert H., Olson, Joshua, Caldera, J.R., Sepich-Poore, Gregory D., Carrillo-Terrazas, Marvic, Tsai, Chih-Ming, Vargas, Fernando, Knight, Rob, Dorrestein, Pieter C., Liu, George Y., Nizet, Victor, Sakoulas, George, Rose, Warren, Gonzalez, David J.

“…Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying mortality rates of ∼25%. The ability to rapidly predict SaB patient…”
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Reuniting philosophy and science to advance cancer research by Pradeu, Thomas, Daignan‐Fornier, Bertrand, Ewald, Andrew, Germain, Pierre‐Luc, Okasha, Samir, Plutynski, Anya, Benzekry, Sébastien, Bertolaso, Marta, Bissell, Mina, Brown, Joel S., Chin‐Yee, Benjamin, Chin‐Yee, Ian, Clevers, Hans, Cognet, Laurent, Darrason, Marie, Farge, Emmanuel, Feunteun, Jean, Galon, Jérôme, Giroux, Elodie, Green, Sara, Gross, Fridolin, Jaulin, Fanny, Knight, Rob, Laconi, Ezio, Larmonier, Nicolas, Maley, Carlo, Mantovani, Alberto, Moreau, Violaine, Nassoy, Pierre, Rondeau, Elena, Santamaria, David, Sawai, Catherine M., Seluanov, Andrei, Sepich‐Poore, Gregory D., Sisirak, Vanja, Solary, Eric, Yvonnet, Sarah, Laplane, Lucie

“…ABSTRACT Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is…”
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Using all our genomes: Blood‐based liquid biopsies for the early detection of cancer by Adams, Eddie, Sepich‐Poore, Gregory D., Miller‐Montgomery, Sandrine, Knight, Rob

“…The pursuit of highly sensitive and specific cancer diagnostics based on cell‐free nucleic acids isolated from minimally invasive liquid biopsies has been an…”
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Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process by Sepich‐Poore, Gregory D., Guccione, Caitlin, Laplane, Lucie, Pradeu, Thomas, Curtius, Kit, Knight, Rob

“…The presence and role of microbes in human cancers has come full circle in the last century. Tumors are no longer considered aseptic, but implications for…”
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Redrawing therapeutic boundaries: microbiota and cancer by Sholl, Jonathan, Sepich-Poore, Gregory D, Knight, Rob, Pradeu, Thomas

“…The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain…”
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Robustness of cancer microbiome signals over a broad range of methodological variation by Sepich-Poore, Gregory D., McDonald, Daniel, Kopylova, Evguenia, Guccione, Caitlin, Zhu, Qiyun, Austin, George, Carpenter, Carolina, Fraraccio, Serena, Wandro, Stephen, Kosciolek, Tomasz, Janssen, Stefan, Metcalf, Jessica L., Song, Se Jin, Kanbar, Jad, Miller-Montgomery, Sandrine, Heaton, Robert, Mckay, Rana, Patel, Sandip Pravin, Swafford, Austin D., Korem, Tal, Knight, Rob

“…In 2020, we identified cancer-specific microbial signals in The Cancer Genome Atlas (TCGA) [ 1 ]. Multiple peer-reviewed papers independently verified or…”
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Retraction Note: Microbiome analyses of blood and tissues suggest cancer diagnostic approach by Poore, Gregory D., Kopylova, Evguenia, Zhu, Qiyun, Carpenter, Carolina, Fraraccio, Serena, Wandro, Stephen, Kosciolek, Tomasz, Janssen, Stefan, Metcalf, Jessica, Song, Se Jin, Kanbar, Jad, Miller-Montgomery, Sandrine, Heaton, Robert, Mckay, Rana, Patel, Sandip Pravin, Swafford, Austin D., Knight, Rob

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The microbiome and prostate cancer by Javier-DesLoges, Juan, McKay, Rana R., Swafford, Austin D., Sepich-Poore, Gregory D., Knight, Rob, Parsons, J. Kellogg

“…There is growing evidence that the microbiome is involved in development and treatment of many human diseases, including prostate cancer. There are several…”
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Correction: Robustness of cancer microbiome signals over a broad range of methodological variation by Sepich-Poore, Gregory D., McDonald, Daniel, Kopylova, Evguenia, Guccione, Caitlin, Zhu, Qiyun, Austin, George, Carpenter, Carolina, Fraraccio, Serena, Wandro, Stephen, Kosciolek, Tomasz, Janssen, Stefan, Metcalf, Jessica L., Song, Se Jin, Kanbar, Jad, Miller-Montgomery, Sandrine, Heaton, Robert, Mckay, Rana, Patel, Sandip Pravin, Swafford, Austin D., Korem, Tal, Knight, Rob

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Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis by Brewer, R Camille, Lanz, Tobias V, Hale, Caryn R, Sepich-Poore, Gregory D, Martino, Cameron, Swafford, Austin D, Carroll, Thomas S, Kongpachith, Sarah, Blum, Lisa K, Elliott, Serra E, Blachere, Nathalie E, Parveen, Salina, Fak, John, Yao, Vicky, Troyanskaya, Olga, Frank, Mayu O, Bloom, Michelle S, Jahanbani, Shaghayegh, Gomez, Alejandro M, Iyer, Radhika, Ramadoss, Nitya S, Sharpe, Orr, Chandrasekaran, Sangeetha, Kelmenson, Lindsay B, Wang, Qian, Wong, Heidi, Torres, Holly L, Wiesen, Mark, Graves, Dana T, Deane, Kevin D, Holers, V Michael, Knight, Rob, Darnell, Robert B, Robinson, William H, Orange, Dana E

“…Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating…”
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Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma by Lim, Weng Khong, Ong, Choon Kiat, Tan, Jing, Thike, Aye Aye, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Myint, Swe Swe, Nagarajan, Sanjanaa, Nasir, Nur Diyana Md, McPherson, John R, Cutcutache, Ioana, Poore, Gregory, Tay, Su Ting, Ooi, Wei Siong, Tan, Veronique Kiak Mien, Hartman, Mikael, Ong, Kong Wee, Tan, Benita K T, Rozen, Steven G, Tan, Puay Hoon, Tan, Patrick, Teh, Bin Tean

“…Bin Tean Teh and colleagues report exome sequencing of 8 breast fibroadenomas and follow-up targeted sequencing in 90 additional samples. They find that 59% of…”
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Phylogeny-Aware Analysis of Metagenome Community Ecology Based on Matched Reference Genomes while Bypassing Taxonomy by Zhu, Qiyun, Huang, Shi, Gonzalez, Antonio, McGrath, Imran, McDonald, Daniel, Haiminen, Niina, Armstrong, George, Vázquez-Baeza, Yoshiki, Yu, Julian, Kuczynski, Justin, Sepich-Poore, Gregory D, Swafford, Austin D, Das, Promi, Shaffer, Justin P, Lejzerowicz, Franck, Belda-Ferre, Pedro, Havulinna, Aki S, Méric, Guillaume, Niiranen, Teemu, Lahti, Leo, Salomaa, Veikko, Kim, Ho-Cheol, Jain, Mohit, Inouye, Michael, Gilbert, Jack A, Knight, Rob

“…We introduce the operational genomic unit (OGU) method, a metagenome analysis strategy that directly exploits sequence alignment hits to individual reference…”
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A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies by Poore, Gregory D, Ko, Emily R, Valente, Ashlee, Henao, Ricardo, Sumner, Kelsey, Hong, Christopher, Burke, Thomas W, Nichols, Marshall, McClain, Micah T, Huang, Erich S, Ginsburg, Geoffrey S, Woods, Christopher W, Tsalik, Ephraim L

“…Acute respiratory infections (ARIs) are the leading indication for antibacterial prescriptions despite a viral etiology in the majority of cases. The lack of…”
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Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance by Vettore, Andre Luiz, Ramnarayanan, Kalpana, Poore, Gregory, Lim, Kevin, Ong, Choon Kiat, Huang, Kie Kyon, Leong, Hui Sun, Chong, Fui Teen, Lim, Tony Kiat-Hon, Lim, Weng Khong, Cutcutache, Ioana, Mcpherson, John R, Suzuki, Yuka, Zhang, Shenli, Skanthakumar, Thakshayeni, Wang, Weining, Tan, Daniel S W, Cho, Byoung Chul, Teh, Bin Tean, Rozen, Steve, Tan, Patrick, Iyer, N Gopalakrishna

“…Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three…”
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