Search Results - "Poorbaugh, Josh"

COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccine by Huhn, Gregory, Poorbaugh, Josh, Zhang, Lin, Beasley, Stephanie, Nirula, Ajay, Brothers, Jennifer, Welbel, Sharon, Wilson, James, Gillani, Sheena, Weber, Kathleen M, Morack, Ralph, Keckler, Kody, Benschop, Robert J

“…Background The humoral response to SARS-CoV-2 can provide immunity and prevent reinfection. However, less is known about how the diversity, magnitude, and…”
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Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab by Sims, Jonathan T, Poorbaugh, Josh, Chang, Ching-Yun, Holzer, Timothy R, Zhang, Lin, Engle, Sarah M, Beasley, Stephanie, Doman, Thompson N, Naughton, Lynn, Higgs, Richard E, Kallewaard, Nicole, Benschop, Robert J

“…A thorough understanding of a patient's inflammatory response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is crucial to…”
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Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression by Schroderus, Anna-Mari, Poorbaugh, Josh, McElyea, Samantha, Beasley, Stephanie, Zhang, Lin, Näntö-Salonen, Kirsti, Rintamäki, Reeta, Pihlajamäki, Jussi, Knip, Mikael, Veijola, Riitta, Toppari, Jorma, Ilonen, Jorma, Benschop, Robert J, Kinnunen, Tuure

“…IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to…”
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Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together by Zhang, Lin, Poorbaugh, Josh, Dougan, Michael, Chen, Peter, Gottlieb, Robert L, Huhn, Gregory, Beasley, Stephanie, Daniels, Montanea, Ngoc Vy Trinh, Thi, Crisp, Melissa, Freitas, Joshua Joaquin, Vaillancourt, Peter, Patel, Dipak R, Nirula, Ajay, Kallewaard, Nicole L, Higgs, Richard E, Benschop, Robert J

“…Neutralizing monoclonal antibodies (mAbs) to SARS-CoV-2 are clinically efficacious when administered early, decreasing hospitalization and mortality in…”
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Longitudinal assessment of systemic steroid therapy on hyperinflammatory endothelial biomarker profiles and serology responses of COVID-19 patients by Sims, Jonathan T, Chang, Ching-Yun, Poorbaugh, Josh, Daniels, Montanea, Beasley, Stephanie L, Zhang, Lin, Rodgers, George H, Lena, Fabio, Lacerenza, Leonardo G, Sposato, Bruno, Dupont, Annabelle, Susen, Sophie, Casalini, Giacomo, Corbellino, Mario, Stebbing, Justin, Krishnan, Venkatesh

“…Keywords: COVID-19, CXCL9, Cytokine, Dexamethasone, Inflammation, Serology…”
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Safety, Tolerability, and Pharmacokinetics of an Oral Small Molecule Inhibitor of IL‐17A (LY3509754): A Phase I Randomized Placebo‐Controlled Study by Datta‐Mannan, Amita, Regev, Arie, Coutant, David E., Dropsey, Andrew J., Foster, Joanne, Jones, Spencer, Poorbaugh, Josh, Schmitz, Carsten, Wang, Evan, Woodman, Michael E.

“…For some patients with psoriasis, orally administered small molecule inhibitors of interleukin (IL)‐17A may represent a convenient alternative to…”
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First‐in‐Human Study of Bamlanivimab in a Randomized Trial of Hospitalized Patients With COVID‐19 by Chen, Peter, Datta, Gourab, Grace Li, Ying, Chien, Jenny, Price, Karen, Chigutsa, Emmanuel, Brown‐Augsburger, Patricia, Poorbaugh, Josh, Fill, Jeffrey, Benschop, Robert J., Rouphael, Nadine, Kay, Ariel, Mulligan, Mark J., Saxena, Amit, Fischer, William A., Dougan, Michael, Klekotka, Paul, Nirula, Ajay, Benson, Charles

“…Therapeutics for patients hospitalized with coronavirus disease 2019 (COVID‐19) are urgently needed during the pandemic. Bamlanivimab is a potent neutralizing…”
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The anti-SARS-CoV-2 monoclonal antibody bamlanivimab minimally affects the endogenous immune response to COVID-19 vaccination by Benschop, Robert J, Tuttle, Jay L, Zhang, Lin, Poorbaugh, Josh, Kallewaard, Nicole L, Vaillancourt, Peter, Crisp, Melissa, Trinh, Thi Ngoc Vy, Freitas, Joshua J, Beasley, Stephanie, Daniels, Montanea, Haustrup, Natalie, Higgs, Richard E, Nirula, Ajay, Cohen, Myron S, Marovich, Mary

“…As the coronavirus disease 2019 (COVID-19) pandemic evolves and vaccine rollout progresses, the availability and demand for monoclonal antibodies for the…”
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Identification of Human T Cell Biomarkers: A Gene Signature for CD8 T Cell Exhaustion and Ultrasensitive Elisa Methods for Il-21 by Poorbaugh, Josh

“…CD8 T cell exhaustion is the progressive, step-wise loss of T cell function due to persistent antigen stimulation. Given the importance of this phenomenon in…”
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Measurement of IL-21 in human serum and plasma using ultrasensitive MSD S-PLEX® and Quanterix SiMoA methodologies by Poorbaugh, Josh, Samanta, Tanushree, Bright, Stuart W., Sissons, Sean E., Chang, Ching-Yun, Oberoi, Pankaj, MacDonald, Angus J., Martin, Andrea P., Cox, Karen L., Benschop, Robert J.

“…IL-21 is a pleiotropic cytokine that plays a key role in modulating inflammatory responses, including the promotion of autoimmune diseases. Several groups have…”
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146. Intact Sense of Taste and Smell During COVID-19 Infection Is Associated with Absence of of SARS-CoV-2 Spike Protein Antibody Responses within 3 Months of Symptomatic Illness by Wilson, James M, Gillani, Sheena, Bencshop, Robert, Poorbaugh, Josh, Nirula, Ajay, Zhang, Lin, Keckler, Kody, Weber, Kathleen, Morack, Ralph, Beasley, Stephanie, Brothers, Jennifer, Huhn, Gregory

“…Abstract Background Although studies show most COVID-19 survivors have post-infection immunity against SARS-CoV-2 that could prevent re-infection, there is…”
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Level and Duration of IgG and Neutralizing Antibodies to SARS-CoV-2 in Children with Symptomatic or Asymptomatic SARS-CoV-2 Infection by Khaitan, Alka, Datta, Dibyadyuti, Bond, Caitlin, Goings, Michael, Co, Katrina, Odhiambo, Eliud O., Miller, Lucy, Zhang, Lin, Beasley, Stephanie, Poorbaugh, Josh, John, Chandy C.

“…Abstract There are conflicting data about level and duration of Abs to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children after…”
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Root cause investigation of a viral contamination incident occurred during master cell bank (MCB) testing and characterization – A case study by Chen, Dayue, Nims, Raymond, Dusing, Sandra, Miller, Pamela, Luo, Wen, Quertinmont, Michelle, Parekh, Bhavin, Poorbaugh, Josh, Boose, Jeri Ann, Atkinson, E. Morrey

“…An adventitious agent contamination occurred during a routine 9 CFR bovine viral screening test at BioReliance for an Eli Lilly Chinese Hamster Ovary (CHO)…”
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