Association of cord blood leptin, soluble leptin receptor, insulin-like growth factor-I and insulin-like growth factor-binding protein-1 on birth indices in healthy full-term newborns

Leptin and insulin-like growth factor-I (IGF-I) promote fetal growth. Their availability is modulated by soluble leptin receptor (SLR) and insulin-like growth factor-binding proteins (IGFBP). Studies that accounted for SLR levels when investigating the association of leptin, IGF-I and IGFBPs on birt...

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Bibliographic Details
Published in:	Hormone research in paediatrics Vol. 81; no. 4; p. 232
Main Authors:	Tennekoon, Kamani H, Poopalapillai, Jayanthiny, Karunanayake, Akila G, Jayasinghe, Hasini D, Kumarasiri, Jayalath M, De S Wijesundera, Ajita P, Karunanayake, Eric H
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2014
Subjects:	Birth Weight - physiology Female Fetal Blood - metabolism Humans Infant, Newborn Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-Like Growth Factor I - metabolism Leptin - blood Male Receptors, Leptin - blood Term Birth - physiology
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Summary:	Leptin and insulin-like growth factor-I (IGF-I) promote fetal growth. Their availability is modulated by soluble leptin receptor (SLR) and insulin-like growth factor-binding proteins (IGFBP). Studies that accounted for SLR levels when investigating the association of leptin, IGF-I and IGFBPs on birth indices are scarce. Cord blood leptin, SLR, IGF-I, IGFBP-1 and their association with birth indices were studied in term newborns (n = 110; males = 60). Data were compared between males and females using the Mann-Whitney U test/unpaired Student's t test as appropriate. Univariate correlations and multiple regression analyses were performed to identify variables significantly influencing birth indices. Birth indices were comparable between male and female newborns. Females had a significantly lower SLR (p = 0.0142), a higher leptin/Ponderal index (p = 0.033) and a higher free leptin index (leptin/SLR) (p = 0.0081). Leptin and male gender positively and IGFBP-1 negatively influenced birth weight (p = 0.0005, p = 0.02, and p = 0.005, respectively) and head circumference (p = 0.0052, p = 0.0098, and p = 0.0183, respectively) when accounted for other variables. When tested in a different multiple regression model, the free leptin index positively influenced crown-heel length (p = 0.0016) in addition to birth weight (p < 0.0001) and head circumference (p = 0.0016). In healthy full-term pregnancies, cord blood leptin and IGFBP-1 exert independent and opposing effects on fetal growth.
ISSN:	1663-2826
DOI:	10.1159/000356919