Search Results - "Poon, Randy Yc"

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver by ALBRECHT, J. H, POON, R. Y. C, AHONEN, C. L, RIELAND, B. M, CHUXIA DENG, CRARY, G. S

“…In tissue culture systems, p21 and p27 inhibit cyclin-dependent kinase (CDK) activity and cell cycle progression in response to numerous stimuli, but little is…”
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Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells by POON, R. Y. C, HUNTER, T

“…The tumor suppressor p53 and its target the CDK inhibitor p21 (Cip1/Waf1) are key components of the cellular response to DNA damage. Insight into how p21 is…”
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DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis by Ye, Fei, Kang, Eunchai, Yu, Chuan, Qian, Xuyu, Jacob, Fadi, Yu, Cong, Mao, Mao, Poon, Randy Y.C., Kim, Jieun, Song, Hongjun, Ming, Guo-li, Zhang, Mingjie

“…Mutations of DISC1 (disrupted-in-schizophrenia 1) have been associated with major psychiatric disorders. Despite the hundreds of DISC1-binding proteins…”
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CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency by Wang, Xiao Qi, Lo, Chung Mau, Chen, Lin, Ngan, Elly S-W, Xu, Aimin, Poon, Randy YC

“…The mechanisms of how signaling pathways are coordinated and integrated for the maintenance of the self-renewal of human embryonic stem cells (hESCs) and the…”
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Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble by Lau, Tsz Yin, Poon, Randy Y C

“…Whole-genome duplication (WGD) is one of the most common genomic abnormalities in cancers. WGD can provide a source of redundant genes to buffer the…”
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Kinesins regulate the heterogeneity in centrosome clustering after whole-genome duplication by Lau, Thomas Ty, Ma, Hoi Tang, Poon, Randy Yc

“…After whole-genome duplication (WGD), tetraploid cells can undergo multipolar mitosis or pseudo-bipolar mitosis with clustered centrosomes. Kinesins play a…”
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DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis by Ye, Fei, Kang, Eunchai, Yu, Chuan, Qian, Xuyu, Jacob, Fadi, Yu, Cong, Mao, Mao, Poon, Randy Y.C., Kim, Jieun, Song, Hongjun, Ming, Guo-li, Zhang, Mingjie

“…(Neuron 96, 1041-1054; December 6, 2017) During the production process of the original article, the term “Nde1l” was inadvertently italicized instead of…”
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DNA damage checkpoints in nasopharyngeal carcinoma by Poon, Randy Y.C

“…Summary Nasopharyngeal carcinoma (NPC) is a highly invasive cancer with poor prognosis. One of the recurring themes of NPC biology and treatments is DNA…”
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Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes by Xing, Xiaoxing, Poon, Randy Y.C., Wong, Cesar S.C., Yobas, Levent

“…We report the label-free enumeration of human colorectal-carcinoma cells from blood lymphocytes by using interdigitated ring-array microelectrodes; this…”
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Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance by Ma, Hoi Tang, Erdal, Sergio, Huang, Shan, Poon, Randy Y.C.

“…The mitotic kinesin KIF11 (also called Eg5) plays critical roles in spindle functions. Although a number of small-molecule inhibitors of KIF11 are currently in…”
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Dovitinib induces mitotic defects and activates the G sub( 2)DNA damage checkpoint by Man, Wing Yu, Mak, Joyce PY, Poon, Randy YC

“…Dovitinib (TKI258; formerly CHIR-258) is an orally bioavailable inhibitor of multiple receptor tyrosine kinases. Interestingly, Dovitinib triggered a G2/M…”
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SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56 by Wong, Wing Ki, Kelly, Terrenz, Li, Jingjing, Ma, Hoi Tang, Poon, Randy Y C

“…Shugoshin (SGO1) plays a pivotal role in sister chromatid cohesion during mitosis by protecting the centromeric cohesin from mitotic kinases and WAPL…”
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Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint by Man, Wing Yu, Mak, Joyce P.Y., Poon, Randy Y.C.

“…Dovitinib (TKI258; formerly CHIR‐258) is an orally bioavailable inhibitor of multiple receptor tyrosine kinases. Interestingly, Dovitinib triggered a G2/M…”
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DNA Damage Mediated S and G2 Checkpoints in Human Embryonal Carcinoma Cells by Wang, XiaoQi, Lui, Vincent C.H., Poon, Ronnie T.P., Lu, Ping, Poon, Randy Y.C.

“…For mouse embryonic stem (ES) cells, the importance of the S and G2 cell cycle checkpoints for genomic integrity is increased by the absence of the G1…”
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Cyclin A2-Cyclin-Dependent Kinase 2 Cooperates with the PLK1-SCF?-TrCP1-EMI1-Anaphase-Promoting Complex/Cyclosome Axis To Promote Genome Reduplication in the Absence of Mitosis by Ma, Hoi Tang, Tsang, Yiu Huen, Marxer, Miriam, Poon, Randy YC

“…Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Inhibition of cyclin-dependent kinase 1 (CDK1) with the specific…”
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Ubiquitination of p53 at Multiple Sites in the DNA-Binding Domain by Chan, Wan Mui, Mak, Man Chi, Fung, Tsz Kan, Lau, Anita, Siu, Wai Yi, Poon, Randy Y C

“…The tumor suppressor p53 is negatively regulated by the ubiquitin ligase MDM2. The MDM2 recognition site is at the NH 2 -terminal region of p53, but the…”
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Mitotic phosphorylation: breaking the balance of power by a tactical retreat by Poon, Randy Y C

“…Profound changes in the phosphorylation state of many proteins occur during mitosis. It is well established that many of these mitotic phosphorylations are…”
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The p53 isoform Δp53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity by WAN MUI CHAN, POON, Randy Y. C

“…The transcription factor p53 is one of the most frequently mutated tumor suppressors. Recent progress has unraveled several novel isoforms of p53…”
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G1 checkpoint establishment in vivo during embryonic liver development by Wang, Xiao Qi, Chan, Kwok Kin, Ming, Xiaoyan, Lui, Vincent C H, Poon, Randy Y C, Lo, Chung Mau, Norbury, Chris, Poon, Ronnie T P

“…The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of…”
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The Kinetics of p53 Activation Versus Cyclin E Accumulation Underlies the Relationship between the Spindle-assembly Checkpoint and the Postmitotic Checkpoint by Chan, Ying Wai, On, Kin Fan, Chan, Wan Mui, Wong, Winnie, Siu, Ho On, Hau, Pok Man, Poon, Randy Y.C.

“…Although cells can exit mitotic block aberrantly by mitotic slippage, they are prevented from becoming tetraploids by a p53-dependent postmitotic checkpoint…”
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