BAIAP2L1 enables cancer cell migration and facilitates phospho‐Cofilin asymmetry localization in the border cells

BAIAP2L1 enables cancer cell migration and facilitates phospho‐Cofilin asymmetry localization in the border cells

Abbreviations ALDOA Aldolase A ARP2 Actin-related protein 2 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 CAPZA2 Capping actin protein of muscle Z-line subunit alpha 2 CFL1 Cofilin 1 DMFS Distant metastasis-free survival DOX Doxycycline F-actin Filamentous acti...

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Bibliographic Details
Published in:Cancer communications (London, England) Vol. 42; no. 1; pp. 75 - 79
Main Authors: Pipatpanyanugoon, Nut, Wareesawetsuwan, Nicha, Prasopporn, Sunisa, Poolex, Wannapan, Pisitkun, Trairak, Kaewkong, Worasak, Sampattavanich, Somponnat, Jirawatnotai, Siwanon
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-01-2022
John Wiley and Sons Inc
Wiley
Subjects:
Actin Depolymerizing Factors
Actins
Angiogenesis
Apoptosis
Breast cancer
Cell adhesion & migration
Cell Movement
Humans
Kinases
Letter to the Editor
Letters to the Editor
Localization
Metastasis
Microfilament Proteins
Motility
Neoplasms
Phosphorylation
Polymerization
Proteins
Wound healing
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Summary:Abbreviations ALDOA Aldolase A ARP2 Actin-related protein 2 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 CAPZA2 Capping actin protein of muscle Z-line subunit alpha 2 CFL1 Cofilin 1 DMFS Distant metastasis-free survival DOX Doxycycline F-actin Filamentous actin FLP Filopodium-like protrusion FMNL1 Formin like 1 HA Human influenza hemagglutinin HER-2 Human epidermal growth factor receptor 2 LIMK LIM domain kinase MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide OS Overall survival PAK2 p21 (RAC1) activated kinase 2 pCofilin Ser3-phosphorylated cofilin RWD Relative wound density SD Standard deviation Sh Short hairpin Sh-BAIAP2L1 BAIAP2L1-specific short hairpin RNA Sh-ctrl Non-specific short hairpin RNA shRNAs Short hairpin ribonucleic acids Dear Editor, Cancer invasion and metastasis are among the most clinically relevant cancer hallmarks. [...]we concluded that expressions of BAIAP2L1 were correlated with the ability of cancer cells to migrate and invade. (P-Q) Kaplan-Meier curves revealed the poorer overall survival (OS) and distant metastasis-free survival (DMFS) for HER2-positive breast cancer patients with high BAIAP2L1 expression, compared to the patients with low BAIAP2L1 expression To investigate how BAIAP2L1 contributes to cancer migration, we performed co-immunoprecipitation-mass spectrometry of the BAIAP2L1-containing protein complex in the MCF7 cells expressing 3 × FLAG-BAIAP2L1 (Supplementary Fig. Among the top 40 BAIAP2L1-interacting proteins were proteins in cell migration and/or wound healing, namely Aldolase A (ALDOA), Cofilin (CFL1), Capping actin protein of muscle Z-line subunit alpha 2 (CAPZA2) (Supplementary Fig.
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ISSN:2523-3548
2523-3548
DOI:10.1002/cac2.12239