Search Results - "Poole, Leslie"

The basics of thiols and cysteines in redox biology and chemistry by Poole, Leslie B.

“…Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly conserved residue within functional (regulatory, catalytic, or…”
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Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling by Perkins, Arden, Nelson, Kimberly J., Parsonage, Derek, Poole, Leslie B., Karplus, P. Andrew

“…•Prxs are ubiquitous defense enzymes and in some cases signaling regulators.•ROOH orientation and polarization in the active site promotes Prx activity.•The…”
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Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins by Hall, Andrea, Nelson, Kimberly, Poole, Leslie B, Karplus, P Andrew

“…Peroxiredoxins (Prxs), some of nature's dominant peroxidases, use a conserved Cys residue to reduce peroxides. They are highly expressed in organisms from all…”
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Cysteine-based redox switches in enzymes by Klomsiri, Chananat, Karplus, P Andrew, Poole, Leslie B

“…The enzymes involved in metabolism and signaling are regulated by posttranslational modifications that influence their catalytic activity, rates of turnover,…”
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Tuning of Peroxiredoxin Catalysis for Various Physiological Roles by Perkins, Arden, Poole, Leslie B, Karplus, P. Andrew

“…Peroxiredoxins (Prxs) make up an ancient family of enzymes that are the predominant peroxidases for nearly all organisms and play essential roles in reducing…”
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Typical 2-Cys peroxiredoxins - structures, mechanisms and functions by Hall, Andrea, Karplus, P.A, Poole, Leslie B

“…Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part,…”
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Discovering mechanisms of signaling-mediated cysteine oxidation by Poole, Leslie B, Nelson, Kimberly J

“…Accumulating evidence reveals hydrogen peroxide as a key player both as a damaging agent and, from emerging evidence over the past decade, as a second…”
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Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization by Hall, Andrea, Parsonage, Derek, Poole, Leslie B., Karplus, P. Andrew

“…Peroxiredoxins (Prxs) are important peroxidases associated with both antioxidant protection and redox signaling. They use a conserved Cys residue to reduce…”
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Chemical approaches to detect and analyze protein sulfenic acids by Furdui, Cristina M., Poole, Leslie B.

“…Orchestration of many processes relying on intracellular signal transduction is recognized to require the generation of hydrogen peroxide as a second…”
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Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes by Collins, John A., Wood, Scott T., Nelson, Kimberly J., Rowe, Meredith A., Carlson, Cathy S., Chubinskaya, Susan, Poole, Leslie B., Furdui, Cristina M., Loeser, Richard F.

“…Oxidative stress-mediated post-translational modifications of redox-sensitive proteins are postulated as a key mechanism underlying age-related cellular…”
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Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice by Oshikawa, Jin, Urao, Norifumi, Kim, Ha Won, Kaplan, Nihal, Razvi, Masooma, McKinney, Ronald, Poole, Leslie B, Fukai, Tohru, Ushio-Fukai, Masuko

“…Reactive oxygen species (ROS), in particular, H(2)O(2), is essential for full activation of VEGF receptor2 (VEGFR2) signaling involved in endothelial cell (EC)…”
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Distribution and Features of the Six Classes of Peroxiredoxins by Poole, Leslie B, Nelson, Kimberly J

“…Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported…”
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Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis by Das, Archita, Ash, Dipankar, Fouda, Abdelrahman Y., Sudhahar, Varadarajan, Kim, Young-Mee, Hou, Yali, Hudson, Farlyn Z., Stansfield, Brian K., Caldwell, Ruth B., McMenamin, Malgorzata, Littlejohn, Rodney, Su, Huabo, Regan, Maureen R., Merrill, Bradley J., Poole, Leslie B., Kaplan, Jack H., Fukai, Tohru, Ushio-Fukai, Masuko

“…Vascular endothelial growth factor receptor type 2 (VEGFR2, also known as KDR and FLK1) signalling in endothelial cells (ECs) is essential for developmental…”
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Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing by Portillo-Ledesma, Stephanie, Randall, Lía M, Parsonage, Derek, Dalla Rizza, Joaquín, Karplus, P. Andrew, Poole, Leslie B, Denicola, Ana, Ferrer-Sueta, Gerardo

“…Two-cysteine peroxiredoxins (Prx) have a three-step catalytic cycle consisting of (1) reduction of peroxide and formation of sulfenic acid on the enzyme, (2)…”
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Redox proteins by Poole, Leslie B., Thorpe, Colin

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Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases by Poole, Leslie B.

“…Antioxidant defenses include a group of ubiquitous, non-heme peroxidases, designated the peroxiredoxins, which rely on an activated cysteine residue at their…”
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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target by Debnath, Anjan, Parsonage, Derek, Andrade, Rosa M, He, Chen, Cobo, Eduardo R, Hirata, Ken, Chen, Steven, García-Rivera, Guillermina, Orozco, Esther, Martínez, Máximo B, Gunatilleke, Shamila S, Barrios, Amy M, Arkin, Michelle R, Poole, Leslie B, McKerrow, James H, Reed, Sharon L

“…Entamoeba histolytica causes human amebiasis. Although antibiotic therapy for this infection exists, there are limited treatment options for this potentially…”
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Introduction to approaches and tools for the evaluation of protein cysteine oxidation by Poole, Leslie B, Furdui, Cristina M, King, S Bruce

“…Oxidative modifications of cysteine thiols in cellular proteins are pivotal to the way signal-stimulated reactive oxygen species are sensed and elicit…”
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Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways by Poole, Leslie B., Schöneich, Christian

“…Due to their susceptibility towards redox modification, protein thiols represent primary targets for the modulation of protein activity, conformation and…”
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Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress by Long, David L., McCall, Charles E., Poole, Leslie B.

“…Lipopolysaccharide (LPS) is a known inducer of inflammatory signaling which triggers generation of reactive oxygen species (ROS) and cell death in responsive…”
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