Search Results - "Poole, D P"

The involvement of nitric oxide synthase neurons in enteric neuropathies by Rivera, L. R, Poole, D. P., Thacker, M., Furness, J. B.

“…Nitric oxide (NO), produced by the neural nitric oxide synthase enzyme (nNOS) is a transmitter of inhibitory neurons supplying the muscle of the…”
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Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system by Poole, D. P., Godfrey, C., Cattaruzza, F., Cottrell, G. S., Kirkland, J. G., Pelayo, J. C., Bunnett, N. W., Corvera, C. U.

“…Background  Bile acids (BAs) regulate cells by activating nuclear and membrane‐bound receptors. G protein coupled bile acid receptor 1 (GpBAR1) is a…”
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Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease‐activated receptor‐2 by Lieu, T, Savage, E, Zhao, P, Edgington‐Mitchell, L, Barlow, N, Bron, R, Poole, D P, McLean, P, Lohman, R‐J, Fairlie, D P, Bunnett, N W

“…Background and Purpose Diverse proteases cleave protease‐activated receptor‐2 (PAR2) on primary sensory neurons and epithelial cells to evoke pain and…”
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NONRUMINANT NUTRITION SYMPOSIUM: Involvement of gut neural and endocrine systems in pathological disorders of the digestive tract by Furness, J. B, Poole, D. P

“…The functioning of the gastrointestinal tract is under the control of the most extensive system of peripheral neurons in the body, the enteric nervous system,…”
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Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe by Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero‐Alba, R., Edgington‐Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindström, E., Craig, A. W., Graham, B., Vanner, S. J., Bunnett, N. W.

“…Background Proteases play a major role in inflammatory diseases of the gastrointestinal tract. Activatable probes are a major technological advance, enabling…”
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Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission by Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D, Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Małecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A., Storr, M. A.

“…Recent studies implicate TRPV4 receptors in visceral pain signaling and intestinal inflammation. Our aim was to evaluate the role of TRPV4 in the control of…”
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NONRUMINANT NUTRITION SYMPOSIUM: Involvement of gut neural and endocrine systems in pathological disorders of the digestive tract1,2 by Furness, J. B., Poole, D. P.

“…The functioning of the gastrointestinal tract is under the control of the most extensive system of peripheral neurons in the body, the enteric nervous system,…”
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Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons by Poole, D P, Amadesi, S, Rozengurt, E, Thacker, M, Bunnett, N W, Furness, J B

“…Tachykinins, acting through NK(3) receptors (NK(3)R), contribute to excitatory transmission to intrinsic primary afferent neurons (IPANs) of the small…”
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A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS by Jiménez-Vargas, N N, Rajasekhar, P, Yeatman, H R, Canals, M, Bunnett, N, Poole, D P, Halls, M L, Reed, D E, Lomax, A E, Vanner, S

“…Abstract Background Endogenous opioids released from CD4+T cells are increased in inflammatory bowel disease patients (IBD) and pre-clinical models of IBD, and…”
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Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome by Cenac, Nicolas, Bautzova, Tereza, Le Faouder, Pauline, Veldhuis, Nicholas A, Poole, Daniel P, Rolland, Corinne, Bertrand, Jessica, Liedtke, Wolfgang, Dubourdeau, Marc, Bertrand-Michel, Justine, Zecchi, Lisa, Stanghellini, Vincenzo, Bunnett, Nigel W, Barbara, Giovanni, Vergnolle, Nathalie

“…Background & Aims In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These…”
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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission by Yarwood, Rebecca E., Imlach, Wendy L., Lieu, TinaMarie, Veldhuis, Nicholas A., Jensen, Dane D., Herenbrink, Carmen Klein, Aurelio, Luigi, Cai, Zhijian, Christie, MacDonald J., Poole, Daniel P., Porter, Christopher J. H., McLean, Peter, Hicks, Gareth A., Geppetti, Pierangelo, Halls, Michelle L., Canals, Meritxell, Bunnett, Nigel W.

“…G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G…”
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The involvement of nitric oxide synthase neurons in enteric neuropathies: NOS neurons in enteric neuropathology by Rivera, L. R, Poole, D. P., Thacker, M., Furness, J. B.

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Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system: GpBAR1 regulates intestinal motility by Poole, D. P., Godfrey, C., Cattaruzza, F., Cottrell, G. S., Kirkland, J. G., Pelayo, J. C., Bunnett, N. W., Corvera, C. U.

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The distribution of purine P2X(2) receptors in the guinea-pig enteric nervous system by Castelucci, Patricia, Robbins, Heather L, Poole, Daniel P, Furness, John B

“…The P2X(2) subtype of purine receptor was localised by immunohistochemistry to nerve cells of the myenteric ganglia of the stomach, small and large intestines…”
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Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons by Chiocchetti, Roberto, Poole, Daniel P, Kimura, Hiroshi, Aimi, Yoshinori, Robbins, Heather L, Castelucci, Patricia, Furness, John B

“…Cholinergic neurons have been revealed in the enteric nervous system by functional and biochemical studies but not by antibodies that provide excellent…”
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Protein kinases expressed by interstitial cells of Cajal by Poole, Daniel P, Van Nguyen, Trung, Kawai, Mitsuhisa, Furness, John B

“…Interstitial cells of Cajal (ICC) are involved in the generation of electrical rhythmicity of intestinal muscle and in the transduction of neural inputs in the…”
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Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons by Nguyen, Trung V., Poole, Daniel P., Harvey, John R., Stebbing, Martin J., Furness, John B.

“…AH neurons in the enteric nervous system play an essential role in initiating intestinal reflexes and factors that control AH neuron excitability therefore…”
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Protein kinase C isoforms in the enteric nervous system by Poole, Daniel P, Hunne, Billie, Robbins, Heather L, Furness, John B

“…C kinases (PKCs) are a family of enzymes essential for the transduction of signals in a diverse range of cell types, including neurons. The different isoforms…”
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