Influence of a Family History of Cancer Within and Across Multiple Sites on Patterns of Cancer Mortality Risk for Women

Influence of a Family History of Cancer Within and Across Multiple Sites on Patterns of Cancer Mortality Risk for Women

A case-control study nested within a large cohort, the American Cancer Society Cancer Prevention Study-1, was conducted to test associations between a family history of cancer and cancer mortality in women. By using logistic regression, the authors analyzed family history, as reported by 429, 483 wo...

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Bibliographic Details
Published in:American journal of epidemiology Vol. 149; no. 5; pp. 454 - 462
Main Authors: Poole, Carol A., Byers, Tim, Calle, Eugenia E., Bondy, Jessica, Fain, Pam, Rodriguez, Carmen
Format: Journal Article
Language:English
Published: Cary, NC Oxford University Press 01-03-1999
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
cohort studies
Confounding Factors (Epidemiology)
Epidemiology
family characteristics
Female
genes
Humans
Logistic Models
Medical sciences
Middle Aged
mortality
neoplasms
Neoplasms - epidemiology
Neoplasms - genetics
Neoplasms - mortality
Population
Proportional Hazards Models
Prospective Studies
Risk Factors
Smoking - epidemiology
Surveys and Questionnaires
Tumors
United States - epidemiology
women
United States
North America
Colorado
America
Human
Family story
Questionnaire
Epidemiologic genetics
Cohort study
Mortality
Risk factor
Female
Case control study
Malignant tumor
Epidemiology
Public health
Americas
Mortality Determinants
Differential Mortality
United States
Risk Factors
Biology
Causes Of Death
North America
Neoplasms
Diseases
Northern America
Developed Countries
Genetics
Population
Demographic Factors
Cancer
Population Dynamics
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Description
Summary:A case-control study nested within a large cohort, the American Cancer Society Cancer Prevention Study-1, was conducted to test associations between a family history of cancer and cancer mortality in women. By using logistic regression, the authors analyzed family history, as reported by 429, 483 women enrolled in 1959, relative to subsequent mortality through 1972 from cancer within and across multiple sites. The associations between family history and cancer mortality were generally stronger within cancer sites than across cancer sites. Within-site associations were found for breast cancer (odds ratio (OR) = 1.9), colorectal cancer (OR = 1.6), stomach cancer (OR = 1.9), and lung cancer (OR = 1.7). Across-site associations were observed for a family history of 1) breast cancer as a risk factor for ovarian cancer mortality (OR = 1.6), 2) stomach cancer as a risk factor for ovarian cancer mortality (OR = 1.5), and 3) uterine cancer as a risk factor for pancreatic cancer mortality (OR = 1.6). A general pattern of positive associations was observed between a family history of cancer at several sites and subsequent death from pancreatic cancer. These findings support the growing body of evidence from cancer genetics suggesting that inherited cancer-susceptibility genes increase the risk for cancer at many sites and are not specific to cancer risk within a single site. Am J Epidemiol 1999; 149:454–62.
Bibliography:ark:/67375/HXZ-HXWS6NPV-M
ArticleID:149.5.454
istex:F6A0CF06BAE585D59D0D77BBD1817F4C836E549A
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a009833