Search Results - "Poole, Candace J."

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity by Alptekin, Ahmet, Ye, Bingwei, Yu, Yajie, Poole, Candace J., van Riggelen, Jan, Zha, Yunhong, Ding, Han-Fei

“…Genomic amplification of the oncogene MYCN is a major driver in the development of high-risk neuroblastoma, a pediatric cancer with poor prognosis. Given the…”
Get full text

MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL by Poole, Candace J, Lodh, Atul, Choi, Jeong-Hyeon, van Riggelen, Jan

“…While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained…”
Get full text

MYC-Master Regulator of the Cancer Epigenome and Transcriptome by Poole, Candace J, van Riggelen, Jan

“…Overexpression of is a hallmark of many human cancers. The oncogene has long been thought to execute its neoplastic functions by acting as a classic…”
Get full text

FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome by Hu, Tianxiang, Wu, Qing, Chong, Yating, Qin, Haiyan, Poole, Candace J., van Riggelen, Jan, Ren, Mingqiang, Cowell, John K.

“…Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing constitutive activation of FGFR1 leads to a stem cell leukemia/lymphoma…”
Get full text

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma by Poole, Candace J, Zheng, Wenli, Lodh, Atul, Yevtodiyenko, Aleksey, Liefwalker, Daniel, Li, Honglin, Felsher, Dean W, van Riggelen, Jan

“…Aberrant DNA methylation is a hallmark of cancer. However, our understanding of how tumor cell-specific DNA methylation patterns are established and maintained…”
Get full text

Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition by Poole, Candace J, Zheng, Wenli, Lee, Haesung, Young, Danielle, Lodh, Atul, Chadli, Ahmed, van Riggelen, Jan

“…Overexpression of the MYC oncogene is a key feature of many human malignancies including Burkitt lymphoma. While MYC is widely regarded to be a promising…”
Get full text

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation by Cai, Yafei, Zhu, Guangxun, Liu, Siyang, Pan, Zezheng, Quintero, Michaela, Poole, Candace J., Lu, Chunwan, Zhu, Huabin, Islam, Bianca, Riggelen, Jan van, Browning, Darren, Liu, Kebin, Blumberg, Richard, Singh, Nagendra, Li, Honglin

“…Intestinal exocrine secretory cells, including Paneth and goblet cells, have a pivotal role in intestinal barrier function and mucosal immunity. Dysfunction of…”
Get full text

Abstract 2613: MYC controls DNA methylation on a global scale through DNMT3b upregulation in T-ALL and Burkitts Lymphoma by Poole, Candace J., Lodh, Atul, Riggelen, Jan van

“…Abstract Background: Oncogenic MYC is implicated in 60-70% of all human cancers, including T-cell acute lymphoblastic leukemia (T-ALL) and Burkitts lymphoma…”
Get full text

MYC deregulates TET1 and TET2 expression to control global DNA by Poole, Candace J, Lodh, Atul, Choi, Jeong-Hyeon, van Riggelen, Jan

“…While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained…”
Get full text