Search Results - "Poole, C. A."

Articular chondrocytes express connexin 43 hemichannels and P2 receptors – a putative mechanoreceptor complex involving the primary cilium? by Knight, M. M., McGlashan, S. R., Garcia, M., Jensen, C. G., Poole, C. A.

“…Mechanical loading is essential for the health and homeostasis of articular cartilage, although the fundamental mechanotransduction pathways are unclear…”
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An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations by Stayner, C., Poole, C. A., McGlashan, S. R., Pilanthananond, M., Brauning, R., Markie, D., Lett, B., Slobbe, L., Chae, A., Johnstone, A. C., Jensen, C. G., McEwan, J. C., Dittmer, K., Parker, K., Wiles, A., Blackburne, W., Leichter, A., Leask, M., Pinnapureddy, A., Jennings, M., Horsfield, J. A., Walker, R. J., Eccles, M. R.

“…Meckel syndrome (MKS) is an inherited autosomal recessive hepatorenal fibrocystic syndrome, caused by mutations in TMEM67 , characterized by occipital…”
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A multicentre, double-blind, randomized, placebo-controlled, parallel group study of multiple treatments of botulinum toxin type A (BoNTA) for the prophylaxis of episodic migraine headaches by Relja, M, Poole, A C, Schoenen, J, Pascual, J, Lei, X, Thompson, C

“…Our aim was to evaluate the safety and efficacy of botulinum toxin type A (BoNTA; BOTOX) for prophylaxis of episodic migraine. In this double-blind,…”
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Short-term frovatriptan for the prevention of difficult-to-treat menstrual migraine attacks by Brandes, J L, Poole, A c, Kallela, M, Schreiber, C P, MacGregor, E A, Silberstein, S D, Tobin, J, Shaw, R

“…The efficacy of a 6-day regimen of frovatriptan for menstrual migraine (MM; attacks starting on day -2 to +3 of menses) prevention in women with…”
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Involvement of corneal nerves in the progression of keratoconus by Brookes, N.H., Loh, I.-P., Clover, G.M., Poole, C.A., Sherwin, T.

“…Keratoconus is a debilitating corneal thinning disease that principally develops in the second and third decades of life. Our group previously developed a…”
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The differential distribution of acetylated and detyrosinated alpha‐tubulin in the microtubular cytoskeleton and primary cilia of hyaline cartilage chondrocytes by POOLE, C. ANTHONY, ZHANG, ZI‐JUN, ROSS, JACQUELINE M.

“…The primary cilium is a ubiquitous cytoplasmic organelle of unknown function. Ultrastructural evidence of primary cilia in chondrocytes, and their…”
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Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ by Jensen, C.G., Poole, C.A., McGlashan, S.R., Marko, M., Issa, Z.I., Vujcich, K.V., Bowser, S.S.

“…Hyaline cartilage chondrocytes express one primary cilium per cell, but its function remains unknown. We examined the ultrastructure of chick embryo sternal…”
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Primary cilia distribution and orientation during involution of the bovine mammary gland by Biet, J, Poole, C A, Stelwagen, K, Margerison, J K, Singh, K

“…The regulation of mammary gland involution occurs through multiple levels including environmental factors, hormones, and local intramammary signals. Primary…”
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In vitro culture of enzymatically isolated chondrons: a possible model for the initiation of osteoarthritis by Ross, J. M., Sherwin, A. F., Poole, C. A.

“…The aim of this study was to assess whether enzymatically isolated chondrons from normal adult articular cartilage could be used as a model for the onset of…”
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The influence of the pericellular microenvironment on the chondrocyte response to osmotic challenge by Hing, W A, Sherwin, A F, Poole, C A

“…To examine whether differences in the pericellular microenvironment of different chondron preparations influence the chondrocyte volume regulatory response to…”
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Influence of a Family History of Cancer Within and Across Multiple Sites on Patterns of Cancer Mortality Risk for Women by Poole, Carol A., Byers, Tim, Calle, Eugenia E., Bondy, Jessica, Fain, Pam, Rodriguez, Carmen

“…A case-control study nested within a large cohort, the American Cancer Society Cancer Prevention Study-1, was conducted to test associations between a family…”
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Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters by McGlashan, S.R., Cluett, E.C., Jensen, C.G., Poole, C.A.

“…Osteoarthritis (OA) is a common joint disease characterized by articular cartilage degeneration. The etiology of OA is unknown. Because several previous…”
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Establishing principles for migraine management in primary care by Dowson, A J, Sender, J, Lipscombe, S, Cady, R K, Tepper, S J, Smith, R, Smith, T R, Taylor, F R, Boudreau, G P, van Duijn, N P, Poole, A C, Baos, V, Wöber, C

“…Published guidelines for the management of migraine in primary care were evaluated by an international advisory board of headache specialists, to establish…”
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Cellular Incursion into Bowman's Membrane in the Peripheral Cone of the Keratoconic Cornea by Sherwin, T., Brookes, N.H., Loh, I.-P., Poole, C.A., Clover, G.M.

“…Analysis of corneal tissue from normal and keratoconic donors has revealed differences which may represent early signs in the pathogenesis of keratoconus…”
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Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose by Knight, M.M., Ross, J.M., Sherwin, A.F., Lee, D.A., Bader, D.L., Poole, C.A.

“…Within articular cartilage, the chondron microenvironment will influence chondrocyte behaviour and response to loading. Chondrons were extracted from intact…”
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Isolated chondrons: a viable alternative for studies of chondrocyte metabolism in vitro by Lee, Greta M., Poole, C. Anthony, Kelley, Scott S., Chang, Jiang, Caterson, Bruce

“…Summary To develop and test a simple enzymatic procedure for isolating chondrons, which consist of the chondrocytes and their surrounding pericellular…”
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Keratocyte networks visualised in the living cornea using vital dyes by POOLE, C. A, BROOKES, N. H, CLOVER, G. M

“…Fluorescent viability probes have been used to visualise and investigate the viability, morphology and organisation of the keratocyte within the stroma of the…”
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Articular cartilage chondrons: form, function and failure by Poole, C A

“…The chondrocyte and its pericellular microenvironment together represent the chondron, historically considered the primary structural, functional and metabolic…”
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Chondrons from articular cartilage. V: Immunohistochemical evaluation of type VI collagen organisation in isolated chondrons by light, confocal and electron microscopy by POOLE, C. A, AYAD, S, GILBERT, R. T

“…The pericellular microenvironment around articular cartilage chondrocytes must play a key role in regulating the interaction between the cell and its…”
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An integrated environmental perfusion chamber and heating system for long‐term, high resolution imaging of living cells by Hing, W. A., Poole, C. A., Jensen, C. G., Watson, M.

“…This communication presents the design and application of an integrated environmental perfusion chamber and stage heating blanket suitable for time‐lapse video…”
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