Search Results - "Poole, April"

Antigenic Restimulation of Virus-Specific Memory CD8 + T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity by Migueles, Stephen A, Rogan, Daniel C, Gavil, Noah V, Kelly, Elizabeth P, Toulmin, Sushila A, Wang, Lawrence T, Lack, Justin, Ward, Addison J, Pryal, Patrick F, Ludwig, Amanda K, Medina, Renata G, Apple, Benjamin J, Toumanios, Christina N, Poole, April L, Rehm, Catherine A, Jones, Sara E, Liang, C Jason, Connors, Mark

“…In various infections or vaccinations of mice or humans, reports of the persistence and the requirements for restimulation of the cytotoxic mediators granzyme…”
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Perplexing paradoxical reactions: navigating the complexity of protracted tuberculosis meningitis—a case report by Gooding, Megan S., Hammoud, Dima A., Epling, Brian, Rocco, Joseph, Laidlaw, Elizabeth, Kuriakose, Safia, Chaturvedi, Mansi, Galindo, Frances, Ma, Stella V., Mystakelis, Harry, Poole, April, Russo, Kelly, Shah, Maunank, Malone, Joseph L., Rupert, Adam W., Sereti, Irini, Manion, Maura

“…Tuberculous meningitis (TBM) has considerable mortality and morbidity, and it often presents therapeutic challenges when complicated by paradoxical reactions…”
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Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine by Matsuda, Kenta, Huang, Jinghe, Zhou, Tongqing, Sheng, Zizhang, Kang, Byong H, Ishida, Elise, Griesman, Trevor, Stuccio, Sarah, Bolkhovitinov, Lyuba, Wohlbold, Teddy J, Chromikova, Veronika, Cagigi, Alberto, Leung, Kwanyee, Andrews, Sarah, Cheung, Crystal S F, Pullano, Alyssa A, Plyler, Jason, Soto, Cinque, Zhang, Baoshan, Yang, Yongping, Joyce, M Gordon, Tsybovsky, Yaroslav, Wheatley, Adam, Narpala, Sandeep R, Guo, Yicheng, Darko, Sam, Bailer, Robert T, Poole, April, Liang, C Jason, Smith, Jon, Alexander, Jeff, Gurwith, Marc, Migueles, Stephen A, Koup, Richard A, Golding, Hana, Khurana, Surender, McDermott, Adrian B, Shapiro, Lawrence, Krammer, Florian, Kwong, Peter D, Connors, Mark

“…Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and…”
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A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity by Matsuda, Kenta, Migueles, Stephen A, Huang, Jinghe, Bolkhovitinov, Lyuba, Stuccio, Sarah, Griesman, Trevor, Pullano, Alyssa A, Kang, Byong H, Ishida, Elise, Zimmerman, Matthew, Kashyap, Neena, Martins, Kelly M, Stadlbauer, Daniel, Pederson, Jessica, Patamawenu, Andy, Wright, Nathaniel, Shofner, Tulley, Evans, Sean, Liang, C Jason, Candia, Julián, Biancotto, Angelique, Fantoni, Giovanna, Poole, April, Smith, Jon, Alexander, Jeff, Gurwith, Marc, Krammer, Florian, Connors, Mark

“…BACKGROUNDTo understand the features of a replicating vaccine that might drive potent and durable immune responses to transgene-encoded antigens, we tested a…”
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An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV by Mystakelis, Harry A., Wilson, Eleanor, Laidlaw, Elizabeth, Poole, April, Krishnan, Sonya, Rupert, Adam, Welker, Jorden L., Gorelick, Robert J., Lisco, Andrea, Manion, Maura, Baker, Jason V., Migueles, Stephen A., Sereti, Irini

“…Residual inflammation in people with HIV (PWH) despite suppression of HIV replication is associated with many comorbidities including cardiovascular disease…”
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A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity by Matsuda, Kenta, Migueles, Stephen A, Huang, Jinghe, Bolkhovitinov, Lyuba, Stuccio, Sarah, Griesman, Trevor, Pullano, Alyssa A, Kang, Byong H, Ishida, Elise, Zimmerman, Matthew, Kashyap, Neena, Martins, Kelly M, Stadlbauer, Daniel, Pederson, Jessica, Patamawenu, Andy, Wright, Nathaniel, Shofner, Tulley, Evans, Sean, Liang, C Jason, Candia, Julián, Biancotto, Angelique, Fantoni, Giovanna, Poole, April, Smith, Jon, Alexander, Jeff, Gurwith, Marc, Krammer, Florian, Connors, Mark

“…BACKGROUND. To understand the features of a replicating vaccine that might drive potent and durable immune responses to transgene-encoded antigens, we tested a…”
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A phase 1, randomized, controlled clinical study of CC-11050 in people living with HIV with suppressed plasma viremia on antiretroviral therapy (APHRODITE) by Boulougoura, Afroditi, Gabriel, Erin, Laidlaw, Elizabeth, Khetani, Vikram, Arakawa, Ken, Higgins, Jeanette, Rupert, Adam, Gorelick, Robert J., Lumbard, Keith, Pau, Alice, Poole, April, Kibiy, Angela, Kumar, Princy, Sereti, Irini

“…Abstract Background Phosphodiesterase 4 inhibitors (PDE4i) block the degradation of cyclic adenosine monophosphate and modulate both innate and adaptive immune…”
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Prolonged Posttreatment Virologic Control and Complete Seroreversion After Advanced Human Immunodeficiency Virus-1 Infection by Uruena, Analia, Cassetti, Isabel, Kashyap, Neena, Deleage, Claire, Estes, Jacob D, Trindade, Christopher, Hammoud, Dima A, Burbelo, Peter D, Natarajan, Ven, Dewar, Robin, Imamichi, Hiromi, Ward, Addison J, Poole, April, Ober, Alexander, Rehm, Catherine, Jones, Sara, Liang, C Jason, Chun, Tae-Wook, Nath, Avindra, Lane, H Clifford, Smith, Bryan R, Connors, Mark, Migueles, Stephen A

“…Abstract Background Possible human immunodeficiency virus (HIV)-1 clearance has rarely been reported. In this study, we describe a unique case of an…”
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A Phase I, Randomized, Controlled Clinical Study of CC-11050 in People Living With HIV With Suppressed Plasma Viremia on Antiretroviral Therapy (APHRODITE) by Boulougoura, Afroditi, Gabriel, Erin, Laidlaw, Elizabeth, Khetani, Vikram, Arakawa, Ken, Higgins, Jeanette, Rupert, Adam, Gorelick, Robert J, Lumbard, Keith, Pau, Alice, Poole, April, Kibiy, Angela, Kumar, Princy, Sereti, Irini

“…Abstract Objective Phosphodiesterase 4 inhibitors (PDE4i) are novel anti-inflammatory medications that have been approved for rheumatologic diseases and have…”
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