Search Results - "Ponzoni, Mirco"

Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer by Ponzoni, Mirco, Pastorino, Fabio, Di Paolo, Daniela, Perri, Patrizia, Brignole, Chiara

“…Macrophages, cells belonging to the innate immune system, present a high plasticity grade, being able to change their phenotype in response to environmental…”
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Recent advances in the developmental origin of neuroblastoma: an overview by Ponzoni, Mirco, Bachetti, Tiziana, Corrias, Maria Valeria, Brignole, Chiara, Pastorino, Fabio, Calarco, Enzo, Bensa, Veronica, Giusto, Elena, Ceccherini, Isabella, Perri, Patrizia

“…Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells undergoing a defective differentiation due to genomic and epigenetic…”
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A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors by Di Giulio, Stefano, Colicchia, Valeria, Pastorino, Fabio, Pedretti, Flaminia, Fabretti, Francesca, Nicolis di Robilant, Vittoria, Ramponi, Valentina, Scafetta, Giorgia, Moretti, Marta, Licursi, Valerio, Belardinilli, Francesca, Peruzzi, Giovanna, Infante, Paola, Goffredo, Bianca Maria, Coppa, Anna, Canettieri, Gianluca, Bartolazzi, Armando, Ponzoni, Mirco, Giannini, Giuseppe, Petroni, Marialaura

“…MYCN drives aggressive behavior and refractoriness to chemotherapy, in several tumors. Since MYCN inactivation in clinical settings is not achievable,…”
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Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma by Brignole, Chiara, Ponzoni, Mirco, Frassoni, Francesco, Morandi, Fabio

“…Neuroblastoma (NB) and malignant melanoma (MM), tumors of pediatric age and adulthood, respectively, share a common origin, both of them deriving from the…”
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A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A by Zeybel, Müjdat, Luli, Saimir, Sabater, Laura, Hardy, Timothy, Oakley, Fiona, Leslie, Jack, Page, Agata, Moran Salvador, Eva, Sharkey, Victoria, Tsukamoto, Hidekazu, Chu, David C.K., Singh, Uma Sharan, Ponzoni, Mirco, Perri, Patrizia, Di Paolo, Daniela, Mendivil, Edgar J., Mann, Jelena, Mann, Derek A.

“…The progression of fibrosis in chronic liver disease is dependent upon hepatic stellate cells (HSCs) transdifferentiating to a myofibroblast-like phenotype…”
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The Olive Leaves Extract Has Anti-Tumor Effects against Neuroblastoma through Inhibition of Cell Proliferation and Induction of Apoptosis by Morandi, Fabio, Bensa, Veronica, Calarco, Enzo, Pastorino, Fabio, Perri, Patrizia, Corrias, Maria Valeria, Ponzoni, Mirco, Brignole, Chiara

“…Neuroblastoma (NB) is the most common extra-cranial solid tumor of pediatric age. The prognosis for high-risk NB patients remains poor, and new treatment…”
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Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt by Marini, Cecilia, Ravera, Silvia, Buschiazzo, Ambra, Bianchi, Giovanna, Orengo, Anna Maria, Bruno, Silvia, Bottoni, Gianluca, Emionite, Laura, Pastorino, Fabio, Monteverde, Elena, Garaboldi, Lucia, Martella, Roberto, Salani, Barbara, Maggi, Davide, Ponzoni, Mirco, Fais, Franco, Raffaghello, Lizzia, Sambuceti, Gianmario

“…Cancer metabolism is characterized by an accelerated glycolytic rate facing reduced activity of oxidative phosphorylation. This “Warburg effect” represents a…”
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Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib by Corallo, Diana, Pastorino, Fabio, Pantile, Marcella, Mariotto, Elena, Caicci, Federico, Viola, Giampietro, Ponzoni, Mirco, Tonini, Gian Paolo, Aveic, Sanja

“…Abstract Background Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer…”
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Cotargeting of miR‐126‐3p and miR‐221‐3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling by Di Paolo, Daniela, Pontis, Francesca, Moro, Massimo, Centonze, Giovanni, Bertolini, Giulia, Milione, Massimo, Mensah, Mavis, Segale, Miriam, Petraroia, Ilaria, Borzi, Cristina, Suatoni, Paola, Brignole, Chiara, Perri, Patrizia, Ponzoni, Mirco, Pastorino, Ugo, Sozzi, Gabriella, Fortunato, Orazio

“…Lung cancer is the leading cause of cancer‐related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since…”
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Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations by Pastorino, Fabio, Capasso, Mario, Brignole, Chiara, Giglio, Serena, Bensa, Veronica, Cantalupo, Sueva, Lasorsa, Vito Alessandro, Tondo, Annalisa, Mura, Rossella, Sementa, Angela Rita, Garaventa, Alberto, Ponzoni, Mirco, Amoroso, Loredana

“…Neuroblastoma (NB) is the most common extracranial solid tumor encountered in childhood. Although there has been significant improvement in the outcomes of…”
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Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors by Bensa, Veronica, Calarco, Enzo, Giusto, Elena, Perri, Patrizia, Corrias, Maria Valeria, Ponzoni, Mirco, Brignole, Chiara, Pastorino, Fabio

“…Retinoids are a class of natural and synthetic compounds derived from vitamin A. They are involved in several biological processes like embryogenesis,…”
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Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma by Zuccari, Guendalina, Milelli, Andrea, Pastorino, Fabio, Loi, Monica, Petretto, Andrea, Parise, Amelia, Marchetti, Chiara, Minarini, Anna, Cilli, Michele, Emionite, Laura, Di Paolo, Daniela, Brignole, Chiara, Piaggio, Francesca, Perri, Patrizia, Tumiatti, Vincenzo, Pistoia, Vito, Pagnan, Gabriella, Ponzoni, Mirco

“…Neuroblastoma is a childhood cancer with poor long-term prognosis in advanced stages. A major aim in neuroblastoma therapy is to develop targeted drug delivery…”
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Enhancement of Tumor Homing by Chemotherapy‐Loaded Nanoparticles by Ponzoni, Mirco, Curnis, Flavio, Brignole, Chiara, Bruno, Silvia, Guarnieri, Daniela, Sitia, Leopoldo, Marotta, Roberto, Sacchi, Angelina, Bauckneht, Matteo, Buschiazzo, Ambra, Rossi, Andrea, Di Paolo, Daniela, Perri, Patrizia, Gori, Alessandro, Sementa, Angela R., Emionite, Laura, Cilli, Michele, Tamma, Roberto, Ribatti, Domenico, Pompa, Pier Paolo, Marini, Cecilia, Sambuceti, Gianmario, Corti, Angelo, Pastorino, Fabio

“…Targeted delivery of anticancer drugs with nanocarriers can reduce side effects and ameliorate therapeutic efficacy. However, poorly perfused and dysfunctional…”
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Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy by Brignole, Chiara, Bensa, Veronica, Fonseca, Nuno A, Del Zotto, Genny, Bruno, Silvia, Cruz, Ana F, Malaguti, Fabiana, Carlini, Barbara, Morandi, Fabio, Calarco, Enzo, Perri, Patrizia, Moura, Vera, Emionite, Laura, Cilli, Michele, De Leonardis, Francesco, Tondo, Annalisa, Amoroso, Loredana, Conte, Massimo, Garaventa, Alberto, Sementa, Angela R, Corrias, Maria V, Ponzoni, Mirco, Moreira, Joao N, Pastorino, Fabio

“…Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Nucleolin (NCL) is a protein overexpressed and…”
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MiR-486-5p Targets CD133+ Lung Cancer Stem Cells through the p85/AKT Pathway by Moro, Massimo, Fortunato, Orazio, Bertolini, Giulia, Mensah, Mavis, Borzi, Cristina, Centonze, Giovanni, Andriani, Francesca, Di Paolo, Daniela, Perri, Patrizia, Ponzoni, Mirco, Pastorino, Ugo, Sozzi, Gabriella, Boeri, Mattia

“…Despite improvements in therapies and screening strategies, lung cancer prognosis still remains dismal, especially for metastatic tumors. Cancer stem cells…”
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Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature- specific ligands potentiates therapeutic efficacy by PASTORINO, Fabio, BRIGNOLE, Chiara, RIBATTI, Domenico, CORTI, Angelo, ALLEN, Theresa M, PONZONI, Mirco, DI PAOLO, Daniela, NICO, Bice, PEZZOLO, Annalisa, MARIMPIETRI, Danilo, PAGNAN, Gabriella, PICCARDI, Federica, CILLI, Michele, LONGHI, Renato

“…Neuroblastoma, the most common solid tumor of infancy derived from the sympathetic nervous system, continues to present a formidable clinical challenge…”
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Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma by Lucarini, Valeria, Melaiu, Ombretta, D’Amico, Silvia, Pastorino, Fabio, Tempora, Patrizia, Scarsella, Marco, Pezzullo, Marco, De Ninno, Adele, D’Oria, Valentina, Cilli, Michele, Emionite, Laura, Infante, Paola, Di Marcotullio, Lucia, De Ioris, Maria Antonietta, Barillari, Giovanni, Alaggio, Rita, Businaro, Luca, Ponzoni, Mirco, Locatelli, Franco, Fruci, Doriana

“…Abstract Background Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a…”
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From the identification of actionable molecular targets to the generation of faithful neuroblastoma patient-derived preclinical models by Capasso, Mario, Brignole, Chiara, Lasorsa, Vito A, Bensa, Veronica, Cantalupo, Sueva, Sebastiani, Enrico, Quattrone, Alessandro, Ciampi, Eleonora, Avitabile, Marianna, Sementa, Angela R, Mazzocco, Katia, Cafferata, Barbara, Gaggero, Gabriele, Vellone, Valerio G, Cilli, Michele, Calarco, Enzo, Giusto, Elena, Perri, Patrizia, Aveic, Sanja, Fruci, Doriana, Tondo, Annalisa, Luksch, Roberto, Mura, Rossella, Rabusin, Marco, De Leonardis, Francesco, Cellini, Monica, Coccia, Paola, Iolascon, Achille, Corrias, Maria V, Conte, Massimo, Garaventa, Alberto, Amoroso, Loredana, Ponzoni, Mirco, Pastorino, Fabio

“…Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Although the overall survival of patients with NB…”
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Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma by Di Paolo, Daniela, Pastorino, Fabio, Zuccari, Guendalina, Caffa, Irene, Loi, Monica, Marimpietri, Danilo, Brignole, Chiara, Perri, Patrizia, Cilli, Michele, Nico, Beatrice, Ribatti, Domenico, Pistoia, Vito, Ponzoni, Mirco, Pagnan, Gabriella

“…Neuroblastoma is an embryonal tumor originating from the simpatico-adrenal lineage of the neural crest. It approximately accounts for about 15% of all…”
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Tumor Regression and Curability of Preclinical Neuroblastoma Models by PEGylated SN38 (EZN-2208), a Novel Topoisomerase I Inhibitor by PASTORINO, Fabio, LOI, Monica, SAPRA, Puja, BECHERINI, Pamela, CILLI, Michele, EMIONITE, Laura, RIBATTI, Domenico, GREENBERGER, Lee M, HORAK, Ivan D, PONZONI, Mirco

“…Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. The antitumor activity of a water soluble pegylated SN38 drug…”
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