Search Results - "Pontini, Guillemette"

Immunological analysis of the murine anti‐CD3‐induced cytokine release syndrome model and therapeutic efficacy of anti‐cytokine antibodies by Nouveau, Lise, Buatois, Vanessa, Cons, Laura, Chatel, Laurence, Pontini, Guillemette, Pleche, Nicolas, Ferlin, Walter G.

“…The aberrant release of inflammatory mediators often referred to as a cytokine storm or cytokine release syndrome (CRS), is a common and sometimes fatal…”
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Autophagy induction by the pathogen receptor CD46 by Joubert, Pierre-Emmanuel, Meiffren, Grégory, Grégoire, Isabel Pombo, Pontini, Guillemette, Richetta, Clémence, Flacher, Monique, Azocar, Olga, Vidalain, Pierre-Olivier, Vidal, Marc, Lotteau, Vincent, Codogno, Patrice, Rabourdin-Combe, Chantal, Faure, Mathias

“…Autophagy is a highly regulated self-degradative mechanism required at a basal level for intracellular clearance and recycling of cytoplasmic contents. Upon…”
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Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors by Hatterer, Eric, Chauchet, Xavier, Richard, Françoise, Barba, Leticia, Moine, Valéry, Chatel, Laurence, Broyer, Lucile, Pontini, Guillemette, Bautzova, Tereza, Juan, Flora, Calloud, Sebastien, Bosson, Nicolas, Charreton, Maud, Masternak, Krzysztof, Buatois, Vanessa, Shang, Limin

“…Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian…”
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CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model by Chauchet, Xavier, Cons, Laura, Chatel, Laurence, Daubeuf, Bruno, Didelot, Gérard, Moine, Valéry, Chollet, Didier, Malinge, Pauline, Pontini, Guillemette, Masternak, Krzysztof, Ferlin, Walter, Buatois, Vanessa, Shang, Limin

“…CD47/SIRPα axis is recognized as an innate immune checkpoint and emerging clinical data validate the interest of interrupting this pathway in cancer,…”
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265 CD47xPD-L1 bispecific antibodies for cancer therapy by Chauchet, Xavier, Pernarrieta, Elise, Bosson, Nicolas, Calloud, Sébastien, Hellequin, Louis, Legrand, Margaux, Viandier, Alizée, Richard, Françoise, Cons, Laura, Malinge, Pauline, Bautzova, Tereza, Bourguignon, Jérémie, Pontini, Guillemette, Sun, Mengzhu, Ravn, Ulla, Moine, Valéry, Poitevin, Yves, Hugues, Stéphanie, Fischer, Nicolas, Shang, Limin, Ferlin, Walter, Masternak, Krzysztof

“…BackgroundPD-1/PD-L1 blockade can significantly improve survival across many types of cancer, but only in a minority of patients. To broaden its therapeutic…”
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Tuning Relative Polypeptide Expression to Optimize Assembly, Yield and Downstream Processing of Bispecific Antibodies by Magistrelli, Giovanni, Pontini, Guillemette, Poitevin, Yves, Malinge, Pauline, Bourguignon, Jérémie, Gauye, Florence, Fleury, Elise, Plèche, Nicolas, Galissaires, Lydia, Fischer, Nicolas

“…Bispecific antibodies (bsAbs) are often composed of several polypeptide chains that have to be expressed adequately to enable optimal assembly and yield of the…”
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Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas by Jain, Salvia, Van Scoyk, Alexandria, Morgan, Elizabeth A., Matthews, Andrew, Stevenson, Kristen, Newton, Gail, Powers, Foster, Autio, Anu, Louissaint, Abner, Pontini, Guillemette, Aster, Jon C., Luscinskas, Francis W., Weinstock, David M.

“…Antibodies that bind CD47 on tumor cells and prevent interaction with SIRPα on phagocytes are active against multiple cancer types including T-cell lymphoma…”
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Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG by Fischer, Nicolas, Elson, Greg, Magistrelli, Giovanni, Dheilly, Elie, Fouque, Nicolas, Laurendon, Amélie, Gueneau, Franck, Ravn, Ulla, Depoisier, Jean-François, Moine, Valery, Raimondi, Sylvain, Malinge, Pauline, Di Grazia, Laura, Rousseau, François, Poitevin, Yves, Calloud, Sébastien, Cayatte, Pierre-Alexis, Alcoz, Mathias, Pontini, Guillemette, Fagète, Séverine, Broyer, Lucile, Corbier, Marie, Schrag, Delphine, Didelot, Gérard, Bosson, Nicolas, Costes, Nessie, Cons, Laura, Buatois, Vanessa, Johnson, Zoe, Ferlin, Walter, Masternak, Krzysztof, Kosco-Vilbois, Marie

“…Bispecific antibodies enable unique therapeutic approaches but it remains a challenge to produce them at the industrial scale, and the modifications introduced…”
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Optimizing assembly and production of native bispecific antibodies by codon de-optimization by Magistrelli, Giovanni, Poitevin, Yves, Schlosser, Florence, Pontini, Guillemette, Malinge, Pauline, Josserand, Soheila, Corbier, Marie, Fischer, Nicolas

“…When production of bispecific antibodies requires the co-expression and assembly of three or four polypeptide chains, low expression of one chain can…”
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Robust Antibody–Antigen Complexes Prediction Generated by Combining Sequence Analyses, Mutagenesis, In Vitro Evolution, X-ray Crystallography and In Silico Docking by Loyau, Jérémy, Didelot, Gérard, Malinge, Pauline, Ravn, Ulla, Magistrelli, Giovanni, Depoisier, Jean-François, Pontini, Guillemette, Poitevin, Yves, Kosco-Vilbois, Marie, Fischer, Nicolas, Thore, Stéphane, Rousseau, François

“…Hu 15C1 is a potent anti-human Toll-like receptor 4 (TLR4) neutralizing antibody. To better understand the molecular basis of its biological activity, we used…”
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Anti-CD79 antibody induces B cell anergy that protects against autoimmunity by Hardy, Ian R, Anceriz, Nadia, Rousseau, François, Seefeldt, Matt B, Hatterer, Eric, Irla, Magali, Buatois, Vanessa, Chatel, Laurence E, Getahun, Andrew, Fletcher, Ashley, Cons, Laura, Pontini, Guillemette, Hertzberg, Nicole A, Magistrelli, Giovanni, Malinge, Pauline, Smith, Mia J, Reith, Walter, Kosco-Vilbois, Marie H, Ferlin, Walter G, Cambier, John C

“…B cells play a major role in the pathogenesis of many autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis,…”
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Abstract 2884: Optimized CD28 bispecific antibodies for targeted activation of T cells within the tumor microenvironment by Majocchi, Sara, Lloveras, Pauline, Burnet-Merlin, Coline, Nouveau, Lise, Pleche, Nicolas, Malinge, Pauline, Batista, Claudia, Daviet, Christelle, Charreton, Maud, Pontini, Guillemette, Gueneau, Franck, Moine, Valery, Magistrelli, Giovanni, Shang, Limin, Ferlin, Walter, Masternak, Krzysztof

“…Abstract Tumor-targeted CD28 bispecific antibodies (bsAbs) are designed to co-stimulate T cells specifically within the tumor microenvironment. By bridging T…”
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Abstract 2951: NI-2901, an affinity-optimized CD47xPD-L1 bispecific antibody for dual immune checkpoint blockade by Chauchet, Xavier, Calloud, Sebastien, LLoveras, Pauline, Bosson, Nicolas, Legrand, Margaux, Chatel, Laurence, Cons, Laura, Lesnier, Adeline, Malinge, Pauline, Pontini, Guillemette, Guillamo, Christophe, Shchelokov, Dmitry, Demin, Oleg, Ravn, Ulla, Moine, Valéry, Daubeuf, Bruno, Magistrelli, Giovanni, Poitevin, Yves, Salgado-Pires, Susana, Shang, Limin, Fischer, Nicolas, Ferlin, Walter, Masternak, Krzysztof

“…Abstract To enhance efficacy of anti-PD-1/PD-L1 antibodies, many combinations with various therapeutic agents are being investigated. Blocking the CD47/SIRPα…”
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Abstract 3428: NI-2901, a CD47xPD-L1 bispecific antibody for dual immune checkpoint blockade with fine-tuned affinity to reduce erythrocyte binding and improve biodistribution by Chauchet, Xavier, Calloud, Sébastien, Legrand, Margaux, Cons, Laura, Chatel, Laurence, Lloveras, Pauline, Burnet-Merlin, Coline, Hellequin, Louis, Bosson, Nicolas, Malinge, Pauline, Pleche, Nicolas, Bourguignon, Jérémie, Pontini, Guillemette, Guillamo, Christophe, Ravn, Ulla, Moine, Valéry, Daubeuf, Bruno, Poitevin, Yves, Magistrelli, Giovanni, Shang, Limin, Ferlin, Walter, Masternak, Krzysztof

“…Abstract Blocking the CD47/SIRPα checkpoint has recently emerged as an effective approach to mobilize the myeloid cell compartment and to improve antitumor…”
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Abstract 3429: NI-2601, an Fc-active CD47xPD-L1 bispecific antibody that selectively targets CD47 on PD-L1-positive tumors by Chauchet, Xavier, Bosson, Nicolas, Legrand, Margaux, Cons, Laura, Calloud, Sébastien, Viandier, Alizée, Richard, Françoise, Malinge, Pauline, Bautzova, Tereza, Bourguignon, Jérémie, Pontini, Guillemette, Penarrieta, Elise, Sun, Mengzhu, Ravn, Ulla, Moine, Valéry, Magistrelli, Giovanni, Poitevin, Yves, Hugues, Stéphanie, Shang, Limin, Ferlin, Walter, Masternak, Krzysztof

“…Abstract PD-1/PD-L1 blockade has improved survival across many types of cancer, but only in a minority of patients. Co-targeting PD-1/PD-L1 and the CD47/SIRPα…”
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Caprine arthritis–encephalitis virus induces apoptosis in infected cells in vitro through the intrinsic pathway by Rea-Boutrois, Angela, Pontini, Guillemette, Greenland, Tim, Mehlen, Patrick, Chebloune, Yahia, Verdier, Gérard, Legras-Lachuer, Catherine

“…Abstract Caprine arthritis–encephalitis virus (CAEV) is a lentivirus that causes natural inflammatory disease in goats, with chronic lesions in several…”
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Optimizing assembly and production of native bispecific antibodies by codon de-optimization by Magistrelli, Giovanni, Poitevin, Yves, Schlosser, Florence, Pontini, Guillemette, Malinge, Pauline, Josserand, Soheila, Corbier, Marie, Fischer, Nicolas

“…When production of bispecific antibodies requires the co-expression and assembly of three or four polypeptide chains, low expression of one chain can…”
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Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors by Hatterer, Eric, Chauchet, Xavier, Richard, Françoise, Barba, Leticia, Moine, Valéry, Chatel, Laurence, Broyer, Lucile, Pontini, Guillemette, Bautzova, Tereza, Juan, Flora, Calloud, Sebastien, Bosson, Nicolas, Charreton, Maud, Masternak, Krzysztof, Buatois, Vanessa, Shang, Limin

“…Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian…”
Get full text