Search Results - "Ponticello, GS"

Pyridazine based inhibitors of p38 MAPK by McIntyre, Charles J, Ponticello, Gerald S, Liverton, Nigel J, O’Keefe, Stephen J, O’Neill, Edward A, Pang, Margaret, Schwartz, Cheryl D, Claremon, David A

“…Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38 MAPK. The most active isomers were those possessing an aryl group α and…”
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On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols by Trost, Barry M, Belletire, John L, Godleski, Stephen, McDougal, Patrick G, Balkovec, James M, Baldwin, John J, Christy, Marcia E, Ponticello, Gerald S, Varga, Sandor L, Springer, James P

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Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma by Baldwin, John J, Ponticello, Gerald S, Anderson, Paul S, Christy, Marcia E, Murcko, Mark A, Randall, William C, Schwam, Harvey, Sugrue, Michael F, Gautheron, Pierre

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Identification and SAR for a selective, nonpeptidyl thrombin inhibitor by Naylor-Olsen, Adel M., Ponticello, Gerald S., Lewis, S.Dale, Mulichak, Anne M., Chen, Zhonguo, Habecker, Charles N., Phillips, Brian T., Sanders, William M., Tucker, Thomas J., Shafer, Jules A., Vacca, Joseph P.

“…A novel, nonpeptidyl thrombin inhibitor, L-636,619 ( 1), was identified via topological similarity searching over the Merck Corporate Sample Database. X-ray…”
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Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity by Graham, Samuel L, Shepard, Kenneth L, Anderson, Paul S, Baldwin, John J, Best, Darryl B, Christy, Marcia E, Freedman, Mark B, Gautheron, Pierre, Habecker, Charles N

“…Derivatives of benzo[b]thiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic…”
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Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors by Ponticello, Gerald S, Freedman, Mark B, Habecker, Charles N, Lyle, Paulette A, Schwam, Harvey, Varga, Sandor L, Christy, Marcia E, Randall, William C, Baldwin, John J

“…An attempt to develop a water-soluble carbonic anhydrase inhibitor focused on exploring structure-activity relationships in the thienothiopyransulfonamide…”
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A synthesis of statine utilizing an oxidative route to chiral .alpha.-amino aldehydes by Rittle, Kenneth E., Homnick, Carl F., Ponticello, Gerald S., Evans, Ben E.

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Useful synthesis of 4-substituted indoles by Ponticello, Gerald S, Baldwin, John J

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A short radiosynthesis of 6-[C3H3]-dorzolamide at very high specific activity and optical purity by Eng, W.-s., Burns, H. D., Ponticello, G. S., Selnick, H. G.

“…6‐[C3H3]‐Dorzolamide was prepared starting from N, N′‐bis‐Boc‐6‐desmethyl‐dorzolamide. An efficient radiosynthesis was developed involving a regioselective and…”
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An unusual dimer of 2-mercaptothiophene by Ponticello, Gerald S, Habecker, Charles N, Varga, Sandor L, Pitzenberger, Steven M

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Utilization of .alpha.,.beta.-unsaturated acids as Michael acceptors for the synthesis of thieno[2,3-b]thiopyrans by Ponticello, Gerald S, Freedman, Mark B, Habecker, Charles N, Holloway, M. Katharine, Amato, Joseph S, Conn, Robin S, Baldwin, John J

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Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2 by Baldwin, J J, Christy, M E, Denny, G H, Habecker, C N, Freedman, M B, Lyle, P A, Ponticello, G S, Varga, S L, Gross, D M, Sweet, C S

“…An attempt to develop a highly cardioselective beta-adrenoceptor antagonist devoid of intrinsic sympathomimetic activity (ISA) focused on exploring…”
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L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity by Sugrue, MF, Gautheron, P, Grove, J, Mallorga, P, Viader, MP, Baldwin, JJ, Ponticello, GS, Varga, SL

“…L-653,328 is the acetate ester of L-652,698 ((S)-3-tert-butylamino-1-[4-[2(hydroxy)ethyl]phenoxy]2-propanol). The penetration of L-652,698 into the albino…”
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MK-927: a topically active ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Gautheron, P, Grove, J, Mallorga, P, Viader, M P, Schwam, H, Baldwin, J J, Christy, M E, Ponticello, G S

“…MK-927 (dl-5,6-dihydro-4-(2-methylpropylamino)-4H-thieno(2,3b)thiopyra n-2-sulfonamide-7,7-dioxide hydrochloride) is a water soluble, carbonic anhydrase…”
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Heterocyclic analogs of the antihypertensive .beta.-adrenergic blocking agent (S)-2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine by Baldwin, John J, Engelhardt, Edward L, Hirschmann, Ralph, Ponticello, Gerald S, Atkinson, Joseph G, Wasson, Burton K, Sweet, Charles S, Scriabine, Alexander

“…The synthesis of a series of isoelectronic analogues of (S)-2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine (1) are described; included in this group…”
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A novel naphthyridinone synthesis via enamine cyclization by Baldwin, J. J, Mensler, K, Ponticello, G. S

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Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class by Baldwin, J J, Denny, G H, Hirschmann, R, Freedman, M B, Ponticello, G S, Gross, D M, Sweet, C S

“…A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for beta-adrenoceptor…”
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Synthesis of 9,10-dihydroanthracen-9,10-imines by Anderson, Paul S, Christy, Marcia E, Colton, C. Dylion, Halczenko, Wasyl, Ponticello, Gerald S, Shepard, Kenneth L

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Functionalization of 5-methyl-2-halonicotinic acid derivatives by Ponticello, Gerald S, Baldwin, John J

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Preparative methods for ergoline synthons: Uhle's ketone and the C-homo analog by Ponticello, G. S, Baldwin, J. J, Lumma, P. K, McClure, D. E

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