Search Results - "Ponterio, G."

Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition by Maltese, M., Martella, G., Imbriani, P., Schuermans, Jeroen, Billion, Karolien, Sciamanna, G., Farook, Febin, Ponterio, G., Tassone, A., Santoro, M., Bonsi, P., Pisani, A., Goodchild, Rose E.

“…Striatal dysfunction is implicated in many movement disorders. However, the precise nature of defects often remains uncharacterized, which hinders therapy…”
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Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia by Martella, G, Maltese, M, Nisticò, R, Schirinzi, T, Madeo, G, Sciamanna, G, Ponterio, G, Tassone, A, Mandolesi, G, Vanni, V, Pignatelli, M, Bonsi, P, Pisani, A

“…Abstract DYT1 dystonia is a movement disorder caused by a deletion in the C-terminal of the protein torsinA. It is unclear how torsinA mutation might disrupt…”
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Models of dystonia: an update by Imbriani, P., Ponterio, G., Tassone, A., Sciamanna, G., El Atiallah, I., Bonsi, P., Pisani, A.

“…•Dystonia is a frequent movement disorder.•DYT1 is the most common form of inherited dystonias.•Multiple animal models of DYT1 dystonia have been generated.•A…”
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Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum by Ponterio, G., Tassone, A., Sciamanna, G., Riahi, E., Vanni, V., Bonsi, P., Pisani, A.

“…Cholinergic interneurons (ChIs) of dorsal striatum play a key role in motor control and in behavioural learning. Neuropeptides regulate cholinergic…”
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Dystonia: Are animal models relevant in therapeutics? by Meringolo, M., Tassone, A., Imbriani, P., Ponterio, G., Pisani, A.

“…Dystonia refers to a heterogeneous group of movement disorders characterized by involuntary, sustained muscle contractions leading to repetitive twisting…”
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Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia by Sciamanna, G., Ponterio, G., Tassone, A., Maltese, M., Madeo, G., Martella, G., Poli, S., Schirinzi, T., Bonsi, P., Pisani, A.

“…Early onset torsion dystonia (DYT1) is an autosomal dominantly inherited disorder caused by deletion in TOR1A gene. Evidence suggests that TOR1A mutation…”
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Aberrant striatal synaptic plasticity in monogenic parkinsonisms by Madeo, G, Martella, G, Schirinzi, T, Ponterio, G, Shen, J, Bonsi, P, Pisani, A

“…Abstract In the recent past, the pathogenesis of Parkinson's disease (PD) has evolved from a neurodegenerative disorder considered entirely sporadic to a…”
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Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M1 muscarinic receptors by Maltese, Marta, Martella, Giuseppina, Madeo, Graziella, Fagiolo, Irene, Tassone, Annalisa, Ponterio, Giulia, Sciamanna, Giuseppe, Burbaud, Pierre, Conn, P. Jeffrey, Bonsi, Paola, Pisani, Antonio

“…Broad‐spectrum muscarinic receptor antagonists have represented the first available treatment for different movement disorders such as dystonia. However, the…”
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ABERRANT STRIATAL SYNAPTIC PLASTICITY IN MONOGENIC PARKINSONISMS: Neuroscience Disease Models by MADEO, G, MARTELLA, G, SCHIRINZI, T, PONTERIO, G, SHEN, J, BONSI, P, PISANI, A

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