Search Results - "Pontel, Lucas B."

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen by Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.

“…Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences…”
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The toxic side of one-carbon metabolism and epigenetics by Morellato, Agustín E., Umansky, Carla, Pontel, Lucas B.

“…One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks. The…”
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Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging by Rieckher, Matthias, Gallrein, Christian, Alquezar-Artieda, Natividad, Bourached-Silva, Nour, Vaddavalli, Pavana Lakshmi, Mares, Devin, Backhaus, Maria, Blindauer, Timon, Greger, Ksenia, Wiesner, Eva, Pontel, Lucas B, Schumacher, Björn

“…Abstract Formaldehyde (FA) is a recognized environmental and metabolic toxin implicated in cancer development and aging. Inherited mutations in the…”
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Illuminating cellular formaldehyde by Umansky, Carla, Morellato, Agustín E., Pontel, Lucas B.

“…Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and…”
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Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity by Umansky, Carla, Morellato, Agustín E., Rieckher, Matthias, Scheidegger, Marco A., Martinefski, Manuela R., Fernández, Gabriela A., Pak, Oleg, Kolesnikova, Ksenia, Reingruber, Hernán, Bollini, Mariela, Crossan, Gerry P., Sommer, Natascha, Monge, María Eugenia, Schumacher, Björn, Pontel, Lucas B.

“…Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking,…”
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Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing by Pontel, Lucas B., Bueno-Costa, Alberto, Morellato, Agustín E., Carvalho Santos, Juliana, Roué, Gaël, Esteller, Manel

“…Ferroptosis is a form of cell death triggered by phospholipid hydroperoxides (PLOOH) generated from the iron-dependent oxidation of polyunsaturated fatty acids…”
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Alternative periplasmic copper-resistance mechanisms in Gram negative bacteria by Pontel, Lucas B, Soncini, Fernando C

“…Bacteria have evolved different systems to tightly control both cytosolic and envelope copper concentration to fulfil their requirements and at the same time,…”
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Identification of a Salmonella ancillary copper detoxification mechanism by a comparative analysis of the genome-wide transcriptional response to copper and zinc excess by Pontel, Lucas B, Scampoli, Nadia L, Porwollik, Steffen, Checa, Susana K, McClelland, Michael, Soncini, Fernando C

“…Copper and zinc are essential metal ions, but toxic in excess. Bacteria have evolved different strategies to control their intracellular concentrations,…”
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Dissecting the Salmonella response to copper by Espariz, Martin, Checa, Susana K, Audero, Maria E. Perez, Pontel, Lucas B, Soncini, Fernando C

“…Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, Departamento de Microbiología, Facultad de…”
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Copper Stress Targets the Rcs System To Induce Multiaggregative Behavior in a Copper-Sensitive Salmonella Strain by PONTEL, Lucas B, PEZZA, Alejandro, SONCINI, Fernando C

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism by Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.

“…The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic…”
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Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells by Bruemmer, Kevin J, Walvoord, Ryan R, Brewer, Thomas F, Burgos-Barragan, Guillermo, Wit, Niek, Pontel, Lucas B, Patel, Ketan J, Chang, Christopher J

“…Formaldehyde (FA) is a reactive signaling molecule that is continuously produced through a number of central biological pathways spanning epigenetics to…”
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UHPLC-HRMS-Based Analysis of S-Hydroxymethyl-Glutathione, GSH, and GSSG in Human Cells by Monge, María Eugenia, Martinefski, Manuela R, Bollini, Mariela, Pontel, Lucas B

“…Glutathione (GSH) is one of the main antioxidant molecules present in cells. It harbors a thiol group responsible for sustaining cellular redox homeostasis…”
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Compartment and signal-specific codependence in the transcriptional control of Salmonella periplasmic copper homeostasis by Pezza, Alejandro, Pontel, Lucas B., López, Carolina, Soncini, Fernando C.

“…Copper homeostasis is essential for bacterial pathogen fitness and infection, and has been the focus of a number of recent studies. In Salmonella, envelope…”
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Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism by Pham, Vanha N, Bruemmer, Kevin J, Toh, Joel D W, Ge, Eva J, Tenney, Logan, Ward, Carl C, Dingler, Felix A, Millington, Christopher L, Garcia-Prieto, Carlos A, Pulos-Holmes, Mia C, Ingolia, Nicholas T, Pontel, Lucas B, Esteller, Manel, Patel, Ketan J, Nomura, Daniel K, Chang, Christopher J

“…One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a…”
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The SASP factor IL‐6 sustains cell‐autonomous senescent cells via a cGAS‐STING‐NFκB intracrine senescent noncanonical pathway by Herbstein, Florencia, Sapochnik, Melanie, Attorresi, Alejandra, Pollak, Cora, Senin, Sergio, Gonilski‐Pacin, David, Ciancio del Giudice, Nicolas, Fiz, Manuel, Elguero, Belén, Fuertes, Mariana, Müller, Lara, Theodoropoulou, Marily, Pontel, Lucas B., Arzt, Eduardo

“…Senescent cells produce a Senescence‐Associated Secretory Phenotype (SASP) that involves factors with diverse and sometimes contradictory activities. One key…”
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Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium by Pontel, Lucas B, Langenick, Judith, Rosado, Ivan V, Zhang, Xiao-Yin, Traynor, David, Kay, Robert R, Patel, Ketan J

“…As time passes, mutations accumulate in the genomes of all living organisms. These changes promote genetic diversity, but also precipitate ageing and the…”
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GolS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon by Pontel, Lucas B, Audero, María E. Pérez, Espariz, Martín, Checa, Susana K, Soncini, Fernando C

“…Salmonella employs a specific set of proteins that allows it to detect the presence of gold salts in the environment and to mount the appropriate resistance…”
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GoIS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon by Pontel, Lucas B, Audero, María E Pérez, Espariz, Martín, Checa, Susana K, Soncini, Fernando C

“…Salmonella employs a specific set of proteins that allows it to detect the presence of gold salts in the environment and to mount the appropriate resistance…”
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Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism by Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.

“…Nature 548, 549–554 (2017); doi:10.1038/nature23481 In this Article, owing to an error during the production process, the keys to the growth curve graphs in…”
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