Search Results - "Ponta, Helmut"

A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis by Tremmel, Martina, Matzke, Alexandra, Albrecht, Imke, Laib, Anna M., Olaku, Vivienne, Ballmer-Hofer, Kurt, Christofori, Gerhard, Héroult, Mélanie, Augustin, Hellmut G., Ponta, Helmut, Orian-Rousseau, Véronique

“…A specific splice variant of the CD44 cell- surface protein family, CD44v6, has been shown to act as a coreceptor for the receptor tyrosine kinase c-Met on…”
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Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of ras and rac by MORRISON, Helen, SPERKA, Tobias, MANENT, Jan, GIOVANNINI, Marco, PONTA, Helmut, HERRLICH, Peter

“…The small G-protein Ras is a tightly controlled regulator of cell fate. Prolonged or persistent arrest in the activated GTP-loaded state by mutation of Ras as…”
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Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin by Orian-Rousseau, Véronique, Morrison, Helen, Matzke, Alexandra, Kastilan, Thor, Pace, Giuseppina, Herrlich, Peter, Ponta, Helmut

“…In several types of cells, the activation of the receptor tyrosine kinase c-Met by its ligand hepatocyte growth factor (HGF) requires the coreceptor CD44v6…”
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CD44 is required for two consecutive steps in HGF/c-Met signaling by Orian-Rousseau, Véronique, Chen, Linfeng, Sleeman, Jonathan P, Herrlich, Peter, Ponta, Helmut

“…The tyrosine kinase receptor c-Met and its ligand HGF/SF, ezrin, and splice variants of CD44 have independently been identified as tumor metastasis-associated…”
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Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid by AHRENS, Thomas, SLEEMAN, Jonathan P, SCHEMPP, Christoph M, HOWELLS, Norma, HOFMANN, Martin, PONTA, Helmut, HERRLICH, Peter, SIMON, Jan C

“…Proteolytic cleavage of the extracellular domain of CD44 from the surface of cells has been observed recently in different cell types. In cell culture…”
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Haploinsufficiency of c-Met in cd44−/− Mice Identifies a Collaboration of CD44 and c-Met In Vivo by Matzke, Alexandra, Sargsyan, Vardanush, Holtmann, Bettina, Aramuni, Gayane, Asan, Esther, Sendtner, Michael, Pace, Giuseppina, Howells, Norma, Zhang, Weiqi, Ponta, Helmut, Orian-Rousseau, Véronique

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression by Sherman, L, Sleeman, J, Herrlich, P, Ponta, H

“…Hyaluronate (HA) is an abundant component of extracellular matrix that is believed to be crucial in many cellular processes, including tissue remodeling, the…”
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CD44 Acts Both as a Growth- and Invasiveness-Promoting Molecule and as a Tumor-Suppressing Cofactor by HERRLICH, PETER, MORRISON, HELEN, SLEEMAN, JONATHAN, ORIAN-ROUSSEAU, VÉRONIQUE, KÖNIG, HARALD, WEG-REMERS, SUSANNE, PONTA, HELMUT

“…: High‐molecular‐weight splice variants of the CD44 transmembrane protein family have been implicated in tumorigenesis and metastasis formation. By contrast,…”
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A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells by Günthert, U, Hofmann, M, Rudy, W, Reber, S, Zöller, M, Haussmann, I, Matzku, S, Wenzel, A, Ponta, H, Herrlich, P

“…Using a monoclonal antibody (MAb1.1ASML) raised against a surface glycoprotein of the metastasizing rat pancreatic carcinoma cell line BSp73ASML, cDNA clones…”
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Splicing choice from ten variant exons establishes CD44 variability by Tölg, Cornelia, Hofmann, Martin, Herrlich, Peter, Ponta, Helmut

“…The enormous heterogeneity of the surface protein designated CD44 is in part due to posttranslational modification, and in part due to differential splicing…”
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Heterogeneous Ribonucleoprotein A1 Is Part of an Exon-specific Splice-silencing Complex Controlled by Oncogenic Signaling Pathways by Matter, Nathalie, Marx, Manuela, Weg-Remers, Susanne, Ponta, Helmut, Herrlich, Peter, König, Harald

“…Regulation of alternative pre-mRNA splicing, recognized as increasingly important in causing human disease, was studied using the CD44 gene, whose splice…”
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Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone by Jonat, C, Rahmsdorf, H J, Park, K K, Cato, A C, Gebel, S, Ponta, H, Herrlich, P

“…Glucocorticoid hormones counteract inflammation and phorbol ester tumor promotion and drastically decrease the expression of several extracellular proteases,…”
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Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44 by Arch, Robert, Wirth, Karin, Hofmann, Martin, Ponta, Helmut, Matzku, Siegfried, Herrlich, Peter, Zöller, Margot

“…A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T…”
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An Essential Role for CD44 Variant Isoforms in Epidermal Langerhans Cell and Blood Dendritic Cell Function by Weiss, Johannes M., Sleeman, Jonathan, Renkl, Andreas C., Dittmar, Henning, Termeer, Christian C., Taxis, Sabine, Howells, Norma, Hofmann, Martin, Köhler, Gabriele, Schöpf, Erwin, Ponta, Helmut, Herrlich, Peter, Simon, Jan C.

“…Upon antigen contact, epidermal Langerhans cells (LC) and dendritic cells (DC) leave peripheral organs and home to lymph nodes via the afferent lymphatic…”
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CD44 expression and regulation during mammary gland development and function by Hebbard, L, Steffen, A, Zawadzki, V, Fieber, C, Howells, N, Moll, J, Ponta, H, Hofmann, M, Sleeman, J

“…The CD44v6 epitope has been widely reported to be expressed in human mammary carcinomas, yet its prognostic significance is controversial and its function in…”
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CD44 variant–specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages by Khaldoyanidi, Sophia, Karakhanova, Svetlana, Sleeman, Jonathan, Herrlich, Peter, Ponta, Helmut

“…Hemopoiesis is regulated by the complex interplay between the bone marrow microenvironment and hemopoietic stem cells and progenitors. The local production of…”
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Comparison of immunohistochemistry and RT-PCR for detection of CD44v-expression, a new prognostic factor in human breast cancer by Dall, P, Heider, K H, Sinn, H P, Skroch-Angel, P, Adolf, G, Kaufmann, M, Herrlich, P, Ponta, H

“…In different human tumors, splice variants of the surface glycoprotein CD44 (CD44v) are correlated with advanced stages of tumor growth and metastatic…”
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Variant Exons v6 and v7 Together Expand the Repertoire of Glycosaminoglycans Bound by CD44 by Sleeman, Jonathan P., Kondo, Kazuhiro, Moll, Jürgen, Ponta, Helmut, Herrlich, Peter

“…Isoforms of the glycoprotein CD44 are cell surface receptors for the glycosaminoglycan hyaluronate. They have been implicated in many biological processes, but…”
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Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein by Hofmann, M, Fieber, C, Assmann, V, Göttlicher, M, Sleeman, J, Plug, R, Howells, N, von Stein, O, Ponta, H, Herrlich, P

“…The extracellular matrix component hyaluronan is believed to play important roles in various processes of organogenesis, cell migration and cancer. Recognition…”
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Interdomain binding mediates tumor growth suppression by the NF2 gene product by SHERMAN, L, XU, H.-M, GEIST, R. T, SAPORITO-IRWIN, S, HOWELLS, N, PONTA, H, HERRLICH, P, GUTMANN, D. H

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