Search Results - "Ponsaerts, Peter"

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis by PRAET, Jelle, GUGLIELMETTI, Caroline, BERNEMAN, Zwi, VAN DER LINDEN, Annemie, PONSAERTS, Peter

“…The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous…”
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Promising Strategies for the Development of Advanced In Vitro Models with High Predictive Power in Ischaemic Stroke Research by Van Breedam, Elise, Ponsaerts, Peter

“…Although stroke is one of the world’s leading causes of death and disability, and more than a thousand candidate neuroprotective drugs have been proposed based…”
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CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice by Pedragosa, Jordi, Miró-Mur, Francesc, Otxoa-de-Amezaga, Amaia, Justicia, Carles, Ruíz-Jaén, Francisca, Ponsaerts, Peter, Pasparakis, Manolis, Planas, Anna M

“…Inflammatory Ly6ChiCCR2+ monocytes infiltrate the brain after stroke but their functions are not entirely clear. We report that CCR2+ monocytes and CCR2+…”
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Transmembrane protein 119 is neither a specific nor a reliable marker for microglia by Vankriekelsvenne, Elise, Chrzanowski, Uta, Manzhula, Katerina, Greiner, Theresa, Wree, Andreas, Hawlitschka, Alexander, Llovera, Gemma, Zhan, Jiangshan, Joost, Sarah, Schmitz, Christoph, Ponsaerts, Peter, Amor, Sandra, Nutma, Erik, Kipp, Markus, Kaddatz, Hannes

“…Microglia are the resident innate immune cells of the central nervous system (CNS) parenchyma. To determine the impact of microglia on disease development and…”
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On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament by Peeleman, Noa, Verdoodt, Dorien, Ponsaerts, Peter, Van Rompaey, Vincent

“…The spiral ligament in the cochlea has been suggested to play a significant role in the pathophysiology of different etiologies of strial hearing loss. Spiral…”
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Microglia: gatekeepers of central nervous system immunology by Tambuyzer, Bart R., Ponsaerts, Peter, Nouwen, Etienne J.

“…Microglia are perhaps the most underestimated cell type of our immune system. Not only were immunologists unaware of their capabilities until recently, but…”
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Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss by Verdoodt, Dorien, Peeleman, Noa, Szewczyk, Krystyna, Van Camp, Guy, Ponsaerts, Peter, Van Rompaey, Vincent

“…Several studies have shown that type IV fibrocytes, located in the spiral ligament, degenerate first after noise exposure. Interestingly, this is the region…”
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Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke by Hamzei Taj, Somayyeh, Le Blon, Debbie, Hoornaert, Chloé, Daans, Jasmijn, Quarta, Alessandra, Praet, Jelle, Van der Linden, Annemie, Ponsaerts, Peter, Hoehn, Mathias

“…Subtle adjustment of the activation status of CNS resident microglia and peripheral macrophages, to promote their neuroprotective and neuroregenerative…”
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Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition by Schepers, Melissa, Hendrix, Sven, Mussen, Femke, van Breedam, Elise, Ponsaerts, Peter, Lemmens, Stefanie, Hellings, Niels, Ricciarelli, Roberta, Fedele, Ernesto, Bruno, Olga, Brullo, Chiara, Prickaerts, Jos, Van Broeckhoven, Jana, Vanmierlo, Tim

“…Spinal cord injury (SCI) is a life-changing event that severely impacts the patient's quality of life. Modulating neuroinflammation, which exacerbates the…”
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Transduction Efficiency and Immunogenicity of Viral Vectors for Cochlear Gene Therapy: A Systematic Review of Preclinical Animal Studies by Verdoodt, Dorien, Peeleman, Noa, Van Camp, Guy, Van Rompaey, Vincent, Ponsaerts, Peter

“…Hearing impairment is the most frequent sensory deficit, affecting 466 million people worldwide and has been listed by the World Health Organization (WHO) as…”
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PapRIV, a BV-2 microglial cell activating quorum sensing peptide by Janssens, Yorick, Debunne, Nathan, De Spiegeleer, Anton, Wynendaele, Evelien, Planas, Marta, Feliu, Lidia, Quarta, Alessandra, Claes, Christel, Van Dam, Debby, De Deyn, Peter Paul, Ponsaerts, Peter, Blurton-Jones, Matthew, De Spiegeleer, Bart

“…Quorum sensing peptides (QSPs) are bacterial peptides produced by Gram-positive bacteria to communicate with their peers in a cell-density dependent manner…”
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Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury by Van Broeckhoven, Jana, Erens, Céline, Sommer, Daniela, Scheijen, Elle, Sanchez, Selien, Vidal, Pia M, Dooley, Dearbhaile, Van Breedam, Elise, Quarta, Alessandra, Ponsaerts, Peter, Hendrix, Sven, Lemmens, Stefanie

“…Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating…”
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Focal white matter lesions induce long-lasting axonal degeneration, neuroinflammation and behavioral deficits by Zhan, Jiangshan, Fegg, Florian Nepomuk, Kaddatz, Hannes, Rühling, Sebastian, Frenz, Julia, Denecke, Bernd, Amor, Sandra, Ponsaerts, Peter, Hochstrasser, Tanja, Kipp, Markus

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with episodes of inflammatory demyelination and remyelination…”
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Generation of four distinct isogenic cell lines with truncating variants in I-band or A-band titin by Boen, Hanne M., Vandendriessche, Bert, Schippers, Jolien, Rabaut, Laura, Nijak-Paeske, Aleksandra, Ponsaerts, Peter, Van Craenenbroeck, Emeline M., Loeys, Bart, Alaerts, Maaike

“…Truncating variants in TTN (TTNtv) are present in 15–25 % of patients with idiopathic dilated cardiomyopathy. Interestingly, the pathogenicity of TTNtv seems…”
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Generation and validation of an iPSC line (BBANTWi008-A) from a Loeys-Dietz Syndrome type 3 patient by Velchev, Joe Davis, Verstraeten, Aline, Meester, Josephina, Ponsaerts, Peter, Richer, Julie, Alaerts, Maaike, Loeys, Bart

“…Loeys-Dietz Syndrome (LDS) is an autosomal dominant connective tissue disorder. The major hallmark of LDS is thoracic aortic aneurysm and dissection (TAAD). We…”
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Generation of an induced pluripotent stem cell (iPSC) line (BBANTWi009-A) from a Meester-Loeys syndrome patient carrying a BGN mutation by De Kinderen, Pauline, Rabaut, Laura, Hebert, Anne, Ponsaerts, Peter, Perik, Melanie, Meester, Josephina A.N.

“…Meester-Loeys syndrome (MRLS) is an X-linked syndromic form of thoracic aortic aneurysm and dissection. Here, we report an iPSC line (BBANTWi009-A) of a boy…”
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The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy by Smits, Evelien L. J. M., Ponsaerts, Peter, Berneman, Zwi N., Van Tendeloo, Viggo F. I.

“…Learning Objectives After completing this course, the reader should be able to: Describe the subtypes of Toll‐like receptor 7 and 8 agonists and their effect…”
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Editorial: Perinatal derivatives and the road to clinical translation, Volume II by Silini, Antonietta R, Parolini, Ornella, Ponsaerts, Peter

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Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation by Boeren, Marlies, de Vrij, Nicky, Ha, My K., Valkiers, Sebastiaan, Souquette, Aisha, Gielis, Sofie, Kuznetsova, Maria, Schippers, Jolien, Bartholomeus, Esther, Van den Bergh, Johan, Michels, Nele, Aerts, Olivier, Leysen, Julie, Bervoets, An, Lambert, Julien, Leuridan, Elke, Wens, Johan, Peeters, Karin, Emonds, Marie-Paule, Elias, George, Vandamme, Niels, Jansens, Hilde, Adriaensen, Wim, Suls, Arvid, Vanhee, Stijn, Hens, Niel, Smits, Evelien, Van Damme, Pierre, Thomas, Paul G., Beutels, Philippe, Ponsaerts, Peter, Van Tendeloo, Viggo, Delputte, Peter, Laukens, Kris, Meysman, Pieter, Ogunjimi, Benson

“…The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts…”
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Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis by Ben-Nejma, Inès R H, Keliris, Aneta J, Vanreusel, Verdi, Ponsaerts, Peter, Van der Linden, Annemie, Keliris, Georgios A

“…Alzheimer's disease (AD) is an incurable neurodegenerative disorder characterised by the progressive buildup of toxic amyloid-beta (Aβ) and tau protein…”
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