Search Results - "Ponomartsev, Sergey V."
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Pluripotent stem cell-based gene therapy approach: human de novo synthesized chromosomes
Published in Cellular and molecular life sciences : CMLS (01-02-2021)“…A novel approach in gene therapy was introduced 20 years ago since artificial non-integrative chromosome-based vectors containing gene loci size inserts were…”
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Human artificial chromosomes for pluripotent stem cell-based tissue replacement therapy
Published in Experimental cell research (01-04-2020)“…The gene therapy approach aiming at curing various human diseases began to develop as a technology from early eighties of the last century. To date the…”
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Long-Term Transcriptomic Changes and Cardiomyocyte Hyperpolyploidy after Lactose Intolerance in Neonatal Rats
Published in International journal of molecular sciences (01-04-2023)“…Many cardiovascular diseases originate from growth retardation, inflammation, and malnutrition during early postnatal development. The nature of this…”
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Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State
Published in International journal of molecular sciences (01-03-2023)“…The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important functions both in the neural system and during embryonic development in…”
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Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage
Published in Stem cell research & therapy (16-12-2019)“…Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or…”
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Transfer of Synthetic Human Chromosome into Human Induced Pluripotent Stem Cells for Biomedical Applications
Published in Cells (Basel, Switzerland) (08-12-2018)“…Alphoid -type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell…”
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Human AlphoidtetO Artificial Chromosome as a Gene Therapy Vector for the Developing Hemophilia A Model in Mice
Published in Cells (Basel, Switzerland) (03-04-2020)“…Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC, are a powerful tool for introducing genes of interest into eukaryotic…”
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Human Artificial Chromosomes and Their Transfer to Target Cells
Published in Actanaturae (01-07-2022)“…Human artificial chromosomes (HACs) have been developed as genetic vectors with the capacity to carry large transgenic constructs or entire gene loci. HACs…”
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Human Alphoid tetO Artificial Chromosome as a Gene Therapy Vector for the Developing Hemophilia A Model in Mice
Published in Cells (Basel, Switzerland) (03-04-2020)“…Human artificial chromosomes (HACs), including the de novo synthesized alphoid -HAC, are a powerful tool for introducing genes of interest into eukaryotic…”
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