Search Results - "Pong U, Kin"

Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage by Huang, Jiawei, U, Kin Pong, Yang, Fuyuan, Ji, Zeyuan, Lin, Jiacheng, Weng, Zhihui, Tsang, Lai Ling, Merson, Tobias D, Ruan, Ye Chun, Wan, Chao, Li, Gang, Jiang, Xiaohua

“…Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in neonates and infants. Mesenchymal stromal cell (MSC)-based therapy is…”
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Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target by Mussai, Francis, Egan, Sharon, Higginbotham-Jones, Joseph, Perry, Tracey, Beggs, Andrew, Odintsova, Elena, Loke, Justin, Pratt, Guy, U, Kin Pong, Lo, Anthony, Ng, Margaret, Kearns, Pamela, Cheng, Paul, De Santo, Carmela

“…Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease…”
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Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs by Liu, Hailong, Huang, Biao, Xue, Shaolong, U, Kin Pong, Tsang, Lai Ling, Zhang, Xiaohu, Li, Gang, Jiang, Xiaohua

“…Abstract Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases…”
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Sarcopenia: Current treatments and new regenerative therapeutic approaches by Lo, Jessica Hiu-tung, U, Kin Pong, Yiu, Tszlam, Ong, Michael Tim-yun, Lee, Wayne Yuk-wai

“…Sarcopenia is characterized by loss of muscle and reduction in muscle strength that contributes to higher mortality rate and increased incidence of fall and…”
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CFTR promotes malignant glioma development via up‐regulation of Akt/Bcl2‐mediated anti‐apoptosis pathway by Zhao, Mingyue, Zhang, Jieting, Huang, Wenqing, Dong, Jianda, Guo, Jinghui, U, Kin Pong, Weng, ZhiHui, Liu, Si, Chan, Hsiao Chang, Feng, Hua, Jiang, Xiaohua

“…Cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP‐activated Cl‐ channel, is extensively expressed in the epithelial cells of various tissues…”
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R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells by Liu, Si, U, Kin Pong, Zhang, Jieting, Tsang, Lai Ling, Huang, Jiawei, Tu, Shui Ping, Jiang, Xiaohua

“…As newly identified Wnt enhancer, R-spondin gene family members have been linked to various cancers; however, their role in isocitrate dehydrogenase-wildtype…”
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Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models by Lam, Sze-Kwan, U, Kin Pong, Li, Yuan-Yuan, Xu, Shi, Cheng, Paul Ning-Man, Ho, James Chung-Man

“…Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. An anti‑proliferative effect of pegylated arginase (BCT‑100) has been shown…”
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Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts by Lam, Sze-Kwan, Li, Yuan-Yuan, Xu, Shi, Leung, Leanne Lee, U, Kin-Pong, Zheng, Yan-Fang, Cheng, Paul Ning-Man, Ho, James Chung-Man

“…Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in…”
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KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization by Huang, Biao, Wang, Bin, Yuk-Wai Lee, Wayne, Pong U, Kin, Leung, Kam Tong, Li, Xican, Liu, Zhenqing, Chen, Rui, Lin, Jia cheng, Tsang, Lai Ling, Liu, Baohua, Ruan, Ye chun, Chan, Hsiao Chang, Li, Gang, Jiang, Xiaohua

“…Epigenomic changes and stem cell deterioration are two hallmarks of aging. Accumulating evidence suggest that senescence of mesenchymal stromal cells (MSCs)…”
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A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 by Danovi, Davide, Folarin, Amos, Gogolok, Sabine, Ender, Christine, Elbatsh, Ahmed M O, Engström, Pär G, Stricker, Stefan H, Gagrica, Sladjana, Georgian, Ana, Yu, Ding, U, Kin Pong, Harvey, Kevin J, Ferretti, Patrizia, Paddison, Patrick J, Preston, Jane E, Abbott, N Joan, Bertone, Paul, Smith, Austin, Pollard, Steven M

“…Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and…”
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Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma by Lam, Sze-Kwan, Yan, Sheng, Xu, Shi, U, Kin-Pong, Cheng, Paul Ning-Man, Ho, James Chung-Man

“…Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate…”
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Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and Modulates Meningeal Lymphatic Function in Middle Cerebral Artery Occlusion Rats by Bai, Shanshan, Lu, Xuan, Pan, Qi, Wang, Bin, Pong U, Kin, Yang, Yongkang, Wang, Haixing, Lin, Sien, Feng, Lu, Wang, Yan, Li, Yucong, Lin, Weiping, Wang, Yujia, Zhang, Xiaoting, Li, Yuan, Li, Linlong, Yang, Zhengmeng, Wang, Ming, Lee, Wayne Yuk-Wai, Jiang, Xiaohua, Li, Gang

“…Ischemic stroke is a leading cause of death and disability worldwide. However, the time window for quickly dissolving clots and restoring cerebral blood flow,…”
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Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase–AIF pathway by U, Kin Pong, Subramanian, Venkataraman, Nicholas, Antony P., Thompson, Paul R., Ferretti, Patrizia

“…PADs (peptidylarginine deiminases) are calcium-dependent enzymes that change protein-bound arginine to citrulline (citrullination/deimination) affecting…”
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Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and Modulates Meningeal Lymphatic Function in Middle Cerebral Artery Occlusion Rats by Bai, Shanshan, Lu, Xuan, Pan, Qi, Wang, Bin, Pong U, Kin, Yang, Yongkang, Wang, Haixing, Lin, Sien, Feng, Lu, Wang, Yan, Li, Yucong, Lin, Weiping, Wang, Yujia, Zhang, Xiaoting, Li, Yuan, Li, Linlong, Yang, Zhengmeng, Wang, Ming, Lee, Wayne Yuk-Wai, Jiang, Xiaohua, Li, Gang

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Inhibition of ornithine decarboxylase to facilitate pegylated arginase treatment in lung adenocarcinoma xenograft model by Ho, James C. M., Lam, Sze Kwan, U, kin Pong, Cheng, Paul Ning-Man

“…Abstract only…”
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Pegylated arginase treatment in mesothelioma xenograft models by Ho, James C. M., Lam, Sze Kwan, U, kin Pong, Cheng, Paul Ning-Man

“…Abstract only…”
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Abstract 5512: Preclinical evaluation of the recombinant human arginase PEG-BCT-100 leading to arginine deprivation in sarcomas by Choy, Chi Tung, Cheong, Hio Teng, U, Kin Pong, Wong, Chi Hang, Loong, Herbert Ho Fung

“…Abstract Background: Arginine deprivation is a novel approach to limit arginine-dependent tumour growth. The presence of enzymes involved in the de novo…”
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