Search Results - "Ponder, Bruce A."

Regulators of genetic risk of breast cancer identified by integrative network analysis by Castro, Mauro A A, de Santiago, Ines, Campbell, Thomas M, Vaughn, Courtney, Hickey, Theresa E, Ross, Edith, Tilley, Wayne D, Markowetz, Florian, Ponder, Bruce A J, Meyer, Kerstin B

“…Kerstin Meyer and colleagues analyze a breast cancer gene regulatory network generated using publicly available expression and ChIP-seq data sets. They…”
Get full text

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
Get full text

Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer by Meyer, Kerstin B, Maia, Ana-Teresa, O'Reilly, Martin, Teschendorff, Andrew E, Chin, Suet-Feung, Caldas, Carlos, Ponder, Bruce A J

“…The recent whole-genome scan for breast cancer has revealed the FGFR2 (fibroblast growth factor receptor 2) gene as a locus associated with a small, but highly…”
Get full text

ERα Binding by Transcription Factors NFIB and YBX1 Enables FGFR2 Signaling to Modulate Estrogen Responsiveness in Breast Cancer by Campbell, Thomas M, Castro, Mauro A A, de Oliveira, Kelin Gonçalves, Ponder, Bruce A J, Meyer, Kerstin B

“…Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers,…”
Get full text

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers by Hayami, Shinya, Kelly, John D., Cho, Hyun‐Soo, Yoshimatsu, Masanori, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Neal, David E., Yamaue, Hiroki, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…A number of histone demethylases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human disease like…”
Get full text

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker by Takawa, Masashi, Masuda, Ken, Kunizaki, Masaki, Daigo, Yataro, Takagi, Katsunori, Iwai, Yukiko, Cho, Hyun‐Soo, Toyokawa, Gouji, Yamane, Yuka, Maejima, Kazuhiro, Field, Helen I., Kobayashi, Takaaki, Akasu, Takayuki, Sugiyama, Masanori, Tsuchiya, Eijyu, Atomi, Yutaka, Ponder, Bruce A. J., Nakamura, Yusuke, Hamamoto, Ryuji

“…The emphasis in anticancer drug discovery has always been on finding a drug with great antitumor potential but few side‐effects. This can be achieved if the…”
Get full text

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers by Yoshimatsu, Masanori, Toyokawa, Gouji, Hayami, Shinya, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Kelly, John D., Neal, David E., Maehara, Yoshihiko, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…Protein arginine methylation is a novel post‐translational modification regulating a diversity of cellular processes, including histone functions, but the…”
Get full text

Demethylation of RB Regulator MYPT1 by Histone Demethylase LSD1 Promotes Cell Cycle Progression in Cancer Cells by CHO, Hyun-Soo, SUZUKI, Takehiro, FIELD, Helen I, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAMAMOTO, Ryuji, DOHMAE, Naoshi, HAYAMI, Shinya, UNOKI, Motoko, YOSHIMATSU, Masanori, TOYOKAWA, Gouji, TAKAWA, Masashi, TAIPING CHEN, KURASH, Julia K

“…Histone demethylase LSD1 (also known as KDM1 and AOF2) is active in various cancer cells, but its biological significance in human carcinogenesis is…”
Get full text

Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysis by Xavier, Joana M., Magno, Ramiro, Russell, Roslin, de Almeida, Bernardo P., Jacinta-Fernandes, Ana, Besouro-Duarte, André, Dunning, Mark, Samarajiwa, Shamith, O’Reilly, Martin, Maia, António M., Rocha, Cátia L., Rosli, Nordiana, Ponder, Bruce A. J., Maia, Ana-Teresa

“…Understanding breast cancer genetic risk relies on identifying causal variants and candidate target genes in risk loci identified by genome-wide association…”
Get full text

Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression by TAKAWA, Masashi, CHO, Hyun-Soo, DOHMAE, Naoshi, FIELD, Helen I, TSUNODA, Tatsuhiko, KOBAYASHI, Takaaki, AKASU, Takayuki, SUGIYAMA, Masanori, OHNUMA, Shin-Ichi, ATOMI, Yutaka, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAYAMI, Shinya, HAMAMOTO, Ryuji, TOYOKAWA, Gouji, KOGURE, Masaharu, YAMANE, Yuka, IWAI, Yukiko, MAEJIMA, Kazuhiro, UEDA, Koji, MASUDA, Akiko

“…Although the physiologic significance of lysine methylation of histones is well known, whether lysine methylation plays a role in the regulation of nonhistone…”
Get full text

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway by Hayami, Shinya, Yoshimatsu, Masanori, Veerakumarasivam, Abhimanyu, Unoki, Motoko, Iwai, Yukiko, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Yamaue, Hiroki, Ponder, Bruce A J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain…”
Get full text

Cancer genetics by Ponder, Bruce A. J

“…Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with…”
Get full text

Multiple Loci With Different Cancer Specificities Within the 8q24 Gene Desert by Ghoussaini, Maya, Song, Honglin, Koessler, Thibaud, Al Olama, Ali Amin, Kote-Jarai, Zsofia, Driver, Kristy E., Pooley, Karen A., Ramus, Susan J., Kjaer, Susanne Krüger, Hogdall, Estrid, DiCioccio, Richard A., Whittemore, Alice S., Gayther, Simon A., Giles, Graham G., Guy, Michelle, Edwards, Stephen M., Morrison, Jonathan, Donovan, Jenny L., Hamdy, Freddie C., Dearnaley, David P., Ardern-Jones, Audrey T., Hall, Amanda L., O'Brien, Lynne T., Gehr-Swain, Beatrice N., Wilkinson, Rosemary A., Brown, Paul M., Hopper, John L., Neal, David E., Pharoah, Paul D. P., Ponder, Bruce A. J., Eeles, Rosalind A., Easton, Douglas F., Dunning, Alison M.

“…Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with…”
Get full text

Association studies for finding cancer-susceptibility genetic variants by Ponder, Bruce A. J, Pharoah, Paul D. P, Dunning, Alison M, Easton, Douglas F

“…Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of…”
Get full text

Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk by de Biase, Maria Stella, Massip, Florian, Wei, Tzu-Ting, Giorgi, Federico M, Stark, Rory, Stone, Amanda, Gladwell, Amy, O'Reilly, Martin, Schütte, Daniel, de Santiago, Ines, Meyer, Kerstin B, Markowetz, Florian, Ponder, Bruce A J, Rintoul, Robert C, Schwarz, Roland F

“…Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in…”
Get full text

Risk Factors for the Incidence of Breast Cancer: Do They Affect Survival From the Disease? by BARNETT, Gillian C, SHAH, Mitul, REDMAN, Karen, EASTON, Douglas F, PONDER, Bruce A. J, PHAROAH, Paul D. P

“…Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis. Data from 4,560 women with invasive breast cancer who had…”
Get full text

Association between common variation in 120 candidate genes and breast cancer risk by Pharoah, Paul D P, Tyrer, Jonathan, Dunning, Alison M, Easton, Douglas F, Ponder, Bruce A J

“…Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have…”
Get full text

The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis by Kang, Daechun, Cho, Hyun-Soo, Toyokawa, Gouji, Kogure, Masaharu, Yamane, Yuka, Iwai, Yukiko, Hayami, Shinya, Tsunoda, Tatsuhiko, Field, Helen I., Matsuda, Koichi, Neal, David E., Ponder, Bruce A. J., Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…Histone lysine methylation plays a fundamental role in chromatin organization. Although a set of histone methyltransferases have been identified and…”
Get full text

Raman micro-spectroscopy for accurate identification of primary human bronchial epithelial cells by Surmacki, Jakub M., Woodhams, Benjamin J., Haslehurst, Alexandria, Ponder, Bruce A. J., Bohndiek, Sarah E.

“…Live cell Raman micro-spectroscopy is emerging as a promising bioanalytical technique for label-free discrimination of a range of different cell types (e.g…”
Get full text

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer by Toyokawa, Gouji, Masuda, Ken, Daigo, Yataro, Cho, Hyun-Soo, Yoshimatsu, Masanori, Takawa, Masashi, Hayami, Shinya, Maejima, Kazuhiro, Chino, Makoto, Field, Helen I, Neal, David E, Tsuchiya, Eiju, Ponder, Bruce A J, Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This…”
Get full text