Search Results - "Ponasik, J A"

Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase by Ponasik, J A, Strickland, C, Faerman, C, Savvides, S, Karplus, P A, Ganem, B

“…The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting…”
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Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors by Faerman, Carlos H., Savvides, Savvas N., Strickland, Corey, Breidenbach, Mark A., Ponasik, James A., Ganem, Bruce, Ripoll, Daniel, Luise Krauth-Siegel, R., Andrew Karplus, P.

“…Benson et al. (Biochem. J.1992, 286, 9) reported three novel competitive inhibitors of trypanothione reductase (TR), which were selected to complement a…”
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Synthesis and Application of Phosphinoferrocenylaminophosphine Ligands for Asymmetric Catalysis by Boaz, Neil W, Mackenzie, Elaine B, Debenham, Sheryl D, Large, Shannon E, Ponasik, James A

“…A new class of bidentate ligands utilizing a phosphine−aminophosphine structure has been prepared on a ferrocenylethyl backbone in a straightforward and…”
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A versatile synthesis of phosphine–aminophosphine ligands for asymmetric catalysis by Boaz, Neil W., Ponasik, James A., Large, Shannon E.

“…[Display omitted] A new and versatile synthesis of phosphine–aminophosphine ligands allows the incorporation of a wide range of nitrogen and phosphorus…”
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The Preparation of Single Enantiomer 2-Naphthylalanine Derivatives Using Rhodium−Methyl BoPhoz-catalyzed Asymmetric Hydrogenation by Boaz, Neil W, Large, Shannon E, Ponasik, James A, Moore, Mary K, Barnette, Theresa, Nottingham, W. Dell

“…The single enantiomers of 2-naphthylalanine and N-tert-butoxycarbonyl 2-naphthylalanine were prepared from 2-naphthaldehyde. The sequence has been optimized…”
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Ferrocenylphosphine-amide ligands for palladium-catalyzed asymmetric allylation by Boaz, Neil W, Ponasik, James A, Large, Shannon E, Debenham, Sheryl D

“…Graphic A new series of phosphine-amide ligands has been prepared on a ferrocenylethyl backbone. These species are effective for enantioselective…”
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Pseudoceratidine, a marine natural product with antifouling activity: Synthetic and biological studies by Ponasik, James A., Conova, Susan, Kinghorn, Denise, Kinney, William A., Rittschof, Daniel, Ganem, Bruce

“…Syntheses of pseudoceratidine and several analogs were developed in order to explore structure-activity relationships responsible for antifouling and…”
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Synthesis of the antifouling polyamine pseudoceratidine and its analogs: Factors influencing biocidal activity by Ponasik, James A, Kassab, Darren J, Ganem, Bruce

“…Syntheses of the title compound 1 and its N 8 and N 1-monoacylated analogs 5 and 8, respectively, are reported. Assays of 1, 5, and 8 indicate that the number…”
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Synthesis of 3-hydroxyspermidine: An unusual polyamine constituent of cytotoxic marine compounds by Ponasik, James A., Ganem, Bruce

“…A short, convergent synthesis of the title compound, (±)-N 1-(3-aminopropyl)-1,4-diamino-2-butanol 6, was accomplished in 42% overall yield by means of a…”
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