Search Results - "Pomposelli, Thomas"

A Strategy to Simultaneously Cure Type 1 Diabetes and Diabetic Nephropathy by Transplant of Composite Islet-Kidney Grafts by Pomposelli, Thomas, Schuetz, Christian, Wang, Ping, Yamada, Kazuhiko

“…In recent years islet cell transplant has proven itself to be a viable clinical option for a select group of diabetic patients. Graft loss after transplant…”
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Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival by Watanabe, Hironosuke, Ariyoshi, Yuichi, Pomposelli, Thomas, Takeuchi, Kazuhiro, Ekanayake‐Alper, Dilrukshi K., Boyd, Lennan K., Arn, Scott J., Sahara, Hisashi, Shimizu, Akira, Ayares, David, Lorber, Marc I., Sykes, Megan, Sachs, David H., Yamada, Kazuhiko

“…Background We have recently demonstrated that human‐CD47 (hCD47) expressed on endothelial cells of porcine lung xenografts extended median graft survival from…”
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Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages by Nomura, Shunichiro, Ariyoshi, Yuichi, Watanabe, Hironosuke, Pomposelli, Thomas, Takeuchi, Kazuhiro, Garcia, Gabriela, Tasaki, Masayuki, Ayares, David, Sykes, Megan, Sachs, David, Johnson, Richard, Yamada, Kazuhiko

“…Background Our initial studies utilizing a galactosyl‐α1‐3‐galactosyltransferase gene knockout (GalTKO) pig‐to‐baboon renal transplant model demonstrated that…”
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Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study by Rivard, Christopher J, Tanabe, Tatsu, Lanaspa, Miguel A, Watanabe, Hironosuke, Nomura, Shunichiro, Andres-Hernando, Ana, Garth, Krystle, Sekijima, Mitsuhiro, Ishimoto, Takuji, Ariyoshi, Yuichi, Garcia, Gabriela E, Shah, Jigesh, Lennan, Boyd, Tasaki, Masayuki, Pomposelli, Thomas, Shimizu, Akira, Sachs, David H, Johnson, Richard J, Yamada, Kazuhiko

“…We have previously reported that co-transplantation of the kidney with vascularized donor thymus from α-1,3-galactosyltransferase gene knockout pigs with an…”
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Preparation of hybrid porcine thymus containing non‐human primate thymic epithelial cells in miniature swine by Sekijima, Mitsuhiro, Sahara, Hisashi, Shimizu, Akira, Iwanaga, Takehiro, Murokawa, Takahiro, Ariyoshi, Yuichi, Pomposelli, Thomas, Khosravi Maharlooei, Mohsen, Sykes, Megan, Yamada, Kazuhiko

“…Background We have achieved greater than a 6‐month survival of a life‐supporting kidney co‐transplanted with a vascularized thymic graft into non‐human…”
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Estimation of Mortality Risk for Vascular Operations by Trainees vs Attending Surgeons by Pomposelli, Thomas, BS, Hart, Joseph, MD, Elliott, Bruce, MD, Robison, Jacob, MD, Brothers, Thomas, MD

“…Objective The development of the ability to estimate patient mortality preoperatively in surgical trainees has not been well studied. Design Prospective…”
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Co-transplantation of Vascularized Thymic Graft with Kidney in Pig-to-Nonhuman Primates for the Induction of Tolerance Across Xenogeneic Barriers by Yamada, Kazuhiko, Ariyoshi, Yuichi, Pomposelli, Thomas, Sekijima, Mitsuhiro

“…Using advanced gene editing technologies, xenotransplantation from multi-transgenic alpha-1,3-galactosyltransferase knockout pigs has demonstrated marked…”
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Intra-bone Bone Marrow Transplantation in Pig-to-Nonhuman Primates for the Induction of Tolerance Across Xenogeneic Barriers by Yamada, Kazuhiko, Ariyoshi, Yuichi, Pomposelli, Thomas, Takeuchi, Kazuhiro

“…Mixed chimerism and thymic tissue transplantation strategies have achieved xenogeneic tolerance in pig-to-mouse models, and both have been extended to…”
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Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation by Pomposelli, Thomas, Wang, Ping, Takeuchi, Kazuhiro, Miyake, Katsunori, Ariyoshi, Yuichi, Watanabe, Hironosuke, Chen, Xiaojuan, Shimizu, Akira, Robertson, Neil, Yamada, Kazuhiko, Moore, Anna

“…The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis,…”
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Lung xenotransplantation by Sahara, Hisashi, Watanabe, Hironosuke, Pomposelli, Thomas, Yamada, Kazuhiko

“…This review describes the most recent progress in xeno lung transplantation (XLTx) to date. It describes the potential mechanisms of early xeno lung graft…”
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Internal mammary usability as recipient vessels in DIEP breast reconstruction in the setting of previous radiation by Leppard, William, Pomposelli, Thomas, Chang, Eric I, Suliman, Ahmed, Herrera, Fernando

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Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation by Takeuchi, Kazuhiro, Ariyoshi, Yuichi, Shimizu, Akira, Okumura, Yuichiro, Cara‐Fuentes, Gabriel, Garcia, Gabriela E., Pomposelli, Thomas, Watanabe, Hironosuke, Boyd, Lennan, Ekanayake‐Alper, Dilrukshi K., Amarnath, Dasari, Sykes, Megan, Sachs, David H., Johnson, Richard J., Yamada, Kazuhiko

“…Background Nephrotic syndrome is a common complication of pig‐to‐baboon kidney xenotransplantation (KXTx) that adversely affects outcomes. We have reported…”
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LIFE-SUPPORTING PIG VASCULARIZED-THYMUS PLUS KIDNEY TRANSPLANTATION LEADS TO GENERATION OF NEW BABOON T-CELLS AND SWINE-SPECIFIC HYPORESPONSIVENESS by Okumura, Yuichiro, Takeuchi, Kazuhiro, Ariyoshi, Yuichi, Pomposelli, Thomas, Boyd, Lennan, Alper, Dilrukshi, Miyake, Katsunori, Okubo, Keita, Arn, Scott, Shimizu, Akira, Ayares, David, Lober, Marc, Sykes, Megan, Sachs, David H., Yamada, Kazuhiko

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The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia–Reperfusion Injury in MHC-Inbred Miniature Swine by Murokawa, Takahiro, Sahara, Hisashi, Sekijima, Mitsuhiro, Pomposelli, Thomas, Iwanaga, Takehiro, Ichinari, Yurika, Shimizu, Akira, Yamada, Kazuhiko

“…Background The development of treatment strategies to protect against ischemia–reperfusion injury (IRI) to livers is important not only for liver surgeries but…”
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Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons by Ariyoshi, Yuichi, Takeuchi, Kazuhiro, Pomposelli, Thomas, Ekanayake‐Alper, Dilrukshi K., Shimizu, Akira, Boyd, Lennan, Estime, Ermance, Ohta, Mayu, Asfour, Arsenoi, Scott Arn, J., Ayares, David, Lorber, Marc, Sykes, Megan, Sachs, David, Yamada, Kazuhiko

“…Background Recent advances in gene editing technology have enabled the production of multi‐knockout (KO) and transgenic pigs in order to overcome immunologic…”
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Transgenic Expression of hCD47 on Vessels in Porcine GalTKO Lung Grafts in Baboons may Mitigate Acute Vascular Rejection in Baboons: Up to 13 Days Graft Survival in Baboons by Watanabe, Hironosuke, Nomura, Shunichiro, Sahara, Hisashi, Pomposelli, Thomas, Ariyoshi, Yuichi, Boyd, Lennan K, Ekanayake-Alper, Dilrukshi K, Tanabe, Tatsu, Glor, Harrison C, Arn, Scott, Hawley, Robert J, Shimizu, Akira, Ayares, David, Lorber, Marc I, Sykes, Megan, Sachs, David H, Yamada, Kazuhiko

“…BACKGROUNDDespite recent progress in survival times of xenografts in nonhuman primates, there are no reports of survival beyond 5 days of histologically…”
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Durable Macrochimerism (>8 weeks) and Pig-Specific T and B Cell Unresponsiveness Following hCD47+ Transgenic GalTKO Pig Intra-Bone Bone Marrow Transplantation in Baboons by Watanabe, Hironosuke, Nomura, Shunichiro, Ariyoshi, Yuichi, Pomposelli, Thomas, Boyd, Lennan K, Tasaki, Masayuki, Ekanayake-Alper, Dilrukshi K, Glor, Harrison C, Arn, Scott, Hawley, Robert J, Sykes, Megan, Sachs, David H, Yamada, Kazuhiko

“…BACKGROUNDRecent data have suggested that low levels of preformed anti-non-Gal natural antibody (nAb) limit xenograft survival. Durable mixed xenogeneic…”
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Transgenic Expression of hCD47 Minimizes the Development of Proteinuria Following Pig-to-Baboon Kidney Transplantation and Reduces Phagocytosis of Porcine Endothelial Cells and Podocytes by Nomura, Shunichiro, Watanabe, Hironosuke, Ariyoshi, Yuichi, Pomposelli, Thomas, Garcia, Gabriela, Sekijima, Mitsuhiro, Boyd, Lennan K, Ekanayake-Alper, Dilrukshi K, Glor, Harrison C, Tanabe, Tatsu, Arn, Scott J Scott J, Hawley, Robert J, Sykes, Megan, Sachs, David H, Richard, Johnson J, Yamada, Kazuhiko

“…BACKGROUNDThe early development of proteinuria following pig renal xenotransplantation (XKTx) was a major obstacle to prolonged life-supporting GalTKO XKTx in…”
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