Search Results - "Pompliano, D L"

Sequence dependence of protein isoprenylation by MOORES, S. L, SCHABER, M. D, MOSSER, S. D, RANDS, E, O'HARA, M. B, GARSKY, V. M, MARSHALL, M. S, POMPLIANO, D. L, GIBBS, J. B

“…Several proteins have been shown to be post-translationally modified on a specific C-terminal cysteine residue by either of two isoprenoid biosynthetic pathway…”
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Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor by Kohl, Nancy E., Mosser, Scott D., deSolms, S. Jane, Giuliani, Elizabeth A., Pompliano, David L., Graham, Samuel L., Smith, Robert L., Scolnick, Edward M., Oliff, Allen, Gibbs, Jackson B.

“…To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue located in a carboxyl-terminal…”
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Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo by GIBBS, J. B, POMPLIANO, D. L, MOSSER, S. D, RANDS, E, LINGHAM, R. B, SHEO BUX SINGH, SCOLNICK, E. M, KOHL, N. E, OLIFF, A

“…The ras oncogene product, Ras, is synthesized in vivo as a precursor protein that requires post-translational processing to become biologically active and to…”
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Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase by Pompliano, David L, Peyman, Anusch, Knowles, Jeremy R

“…The function of the mobile loop of triosephosphate isomerase has been investigated by deleting four contiguous residues from the part of this loop that…”
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Steady-state kinetic mechanism of ras farnesyl:protein transferase by Pompliano, David L, Rands, Elaine, Schaber, Michael D, Mosser, Scott D, Anthony, Neville J, Gibbs, Jackson B

“…The steady-state kinetic mechanism of bovine brain farnesyl:protein transferase (FPTase) has been determined using a series of initial velocity studies,…”
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Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase by Greenlee, Mark L., Laub, Joanne B., Balkovec, James M., Hammond, Milton L., Hammond, Gail G., Pompliano, David L., Epstein-Toney, Jeffrey H.

“…Potent thioester and thiol inhibitors of IMP-1 metallo-β-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step…”
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Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases by KOHL, N. E, DIEHL, R. E, THOMAS, K. A, GIBBS, J. B, SCHABER, M. D, RANDS, E, SODERMAN, D. D, BIN HE, MOORES, S. L, POMPLIANO, D. L, FERRO-NOVICK, S, POWERS, S

“…Farnesyl-protein transferase (FTase) purified from rat or bovine brain is an alpha/beta heterodimer, comprised of subunits having relative molecular masses of…”
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Engineering a Cell-Free Murein Biosynthetic Pathway:  Combinatorial Enzymology in Drug Discovery by Wong, Kenny K, Kuo, David W, Chabin, Renee M, Fournier, Carole, Gegnas, Laura D, Waddell, Sherman T, Marsilio, Frank, Leiting, Barbara, Pompliano, David L

“…More than 40 antibiotics in clinical use, mostly beta -lactams and glycopeptides, act by inhibiting the action of penicillin-binding proteins (PBPs) and attest…”
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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway by Pompliano, David L, Schaber, Michael D, Mosser, Scott D, Omer, Charles A, Shafer, Jules A, Gibbs, Jackson B

“…The catalytic utilization of dimethylallyl, geranyl, farnesyl, and geranylgeranyl diphosphates in the reaction catalyzed by recombinant human farnesyl:protein…”
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Biocatalytic synthesis of aromatics from D-glucose: the role of transketolase by Draths, K. M, Pompliano, D. L, Conley, D. L, Frost, J. W, Berry, A, Disbrow, G. L, Staversky, R. J, Lievense, J. C

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Potent, non-thiol inhibitors of farnesyltransferase by Breslin, Michael J., deSolms, S.Jane, Giuliani, Elizabeth A., Stokker, Gerald E., Graham, Samuel L., Pompliano, David L., Mosser, Scott D., Hamilton, Kelly A., Hutchinson, John H.

“…The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain…”
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2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase by Williams, Theresa M, Ciccarone, Terrence M, MacTough, Suzanne C, Bock, Rhonda L, Conner, Michael W, Davide, Joseph P, Hamilton, Kelly, Koblan, Kenneth S, Kohl, Nancy E, Kral, Astrid M, Mosser, Scott D, Omer, Charles A, Pompliano, David L, Rands, Elaine, Schaber, Michael D, Shah, Daksha, Wilson, Francine R, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Oliff, Allen I, Smith, Robert L

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Degradation and detoxification of organophosphonates. Cleavage of the carbon-phosphorus bond by Cordeiro, M. L, Pompliano, D. L, Frost, J. W

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N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase by deSolms, S. Jane, Giuliani, Elizabeth A, Graham, Samuel L, Koblan, Kenneth S, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine, Scholz, Thomas H, Wiscount, Catherine M, Gibbs, Jackson B, Smith, Robert L

“…Inhibitors of Ras protein farnesyltransferase are described which are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that…”
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An array of target-specific screening strains for antibacterial discovery by Pompliano, David L, DeVito, Joseph A, Mills, Jonathan A, Liu, Veronica G, Agarwal, Anjana, Sizemore, Christine F, Yao, Zhongjie, Stoughton, Daniel M, Cappiello, Maria Grazia, Barbosa, Maria D.F.S, Foster, Lorie A

“…As the global threat of drug- and antibiotic-resistant bacteria continues to rise, new strategies are required to advance the drug discovery process. This work…”
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Pseudodipeptide Inhibitors of Protein Farnesyltransferase by deSolms, S. Jane, Deana, Albert A, Giuliani, Elizabeth A, Graham, Samuel L, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine

“…A series of pseudodipeptide amides are described that inhibit Ras protein farnesyltransferase (PFTase). These inhibitors are truncated versions of the…”
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Phosphonate biosynthesis: molecular cloning of the gene for phosphoenolpyruvate mutase from Tetrahymena pyriformis and overexpression of the gene product in Escherichia coli by Seidel, H. Martin, Pompliano, David L, Knowles, Jeremy R

“…The phosphoenolpyruvate mutase gene from Tetrahymena pyriformis has been cloned and overexpressed in Escherichia coli. To our knowledge, this is the first…”
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Exons as Microgenes? by Seidel, H. Martin, Pompliano, David L., Knowles, Jeremy R.

“…The evolutionary origins of consensus sequences in RNA splicing are discussed. Introns may be failed exons: they were once microgenes originally encoding…”
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Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives by Hammond, Gail G., Huber, Joann L., Greenlee, Mark L., Laub, Joanne B., Young, Katherine, Silver, Lynn L., Balkovec, James M., Pryor, KellyAnn D., Wu, Joseph K., Leiting, Barbara, Pompliano, David L., Toney, Jeffrey H.

“…IMP-1 metallo-β-lactamase is a transferable carbapenem-hydrolyzing enzyme found in some clinical isolates of Pseudomonas aeruginosa, Serratia marcescens and…”
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Conditionally Lethal Escherichia coli Murein Mutants Contain Point Defects That Map to Regions Conserved among Murein and Folyl Poly-γ-glutamate Ligases:  Identification of a Ligase Superfamily by Eveland, Suzanne S, Pompliano, David L, Anderson, Matt S

“…Bacterial peptidoglycan biosynthesis includes four enzymatic reactions in which successive amino acid residues are ligated to uridine diphospho-N-acetylmuramic…”
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