Search Results - "Pompa, José Luis"

Notch Signaling in Development and Cancer by Bolós, Victoria, Grego-Bessa, Joaquín, de la Pompa, José Luis

“…Notch is an evolutionarily conserved local cell signaling mechanism that participates in a variety of cellular processes: cell fate specification,…”
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Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation by del Monte-Nieto, Gonzalo, Ramialison, Mirana, Adam, Arne A. S., Wu, Bingruo, Aharonov, Alla, D’Uva, Gabriele, Bourke, Lauren M., Pitulescu, Mara E., Chen, Hanying, de la Pompa, José Luis, Shou, Weinian, Adams, Ralf H., Harten, Sarah K., Tzahor, Eldad, Zhou, Bin, Harvey, Richard P.

“…In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like network of cardiomyocytes that is critical for contraction and…”
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Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart by Grivas, Dimitrios, González-Rajal, Álvaro, Guerrero Rodríguez, Carlos, Garcia, Ricardo, de la Pompa, José Luis

“…Caveolin-1 is the main structural protein of caveolae, small membrane invaginations involved in signal transduction and mechanoprotection. Here, we generated…”
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Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy by Luxán, Guillermo, Casanova, Jesús C, Martínez-Poveda, Beatriz, Prados, Belén, D'Amato, Gaetano, MacGrogan, Donal, Gonzalez-Rajal, Alvaro, Dobarro, David, Torroja, Carlos, Martinez, Fernando, Izquierdo-García, José Luis, Fernández-Friera, Leticia, Sabater-Molina, María, Kong, Young-Y, Pizarro, Gonzalo, Ibañez, Borja, Medrano, Constancio, García-Pavía, Pablo, Gimeno, Juan R, Monserrat, Lorenzo, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…The Notch signaling pathway has a key role in shaping the developing heart. Guillermo Luxán et al . identify two human mutations in the gene encoding the Notch…”
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Morphogenesis of myocardial trabeculae in the mouse embryo by Captur, Gabriella, Wilson, Robert, Bennett, Michael F, Luxán, Guillermo, Nasis, Arthur, la Pompa, José Luis, Moon, James C, Mohun, Timothy J

“…Formation of trabeculae in the embryonic heart and the remodelling that occurs prior to birth is a conspicuous, but poorly understood, feature of vertebrate…”
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Bmp2 and Notch cooperate to pattern the embryonic endocardium by Papoutsi, Tania, Luna-Zurita, Luis, Prados, Belén, Zaffran, Stéphane, de la Pompa, José Luis

“…Signaling interactions between the myocardium and endocardium pattern embryonic cardiac regions, instructing their development to fulfill specific functions in…”
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Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium by Andrés‐Delgado, Laura, Galardi‐Castilla, María, Münch, Juliane, Peralta, Marina, Ernst, Alexander, González‐Rosa, Juan Manuel, Tessadori, Federico, Santamaría, Luis, Bakkers, Jeroen, Vermot, Julien, Pompa, José Luis, Mercader, Nadia

“…Background The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It…”
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Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages by Prados, Belén, del Toro, Raquel, MacGrogan, Donal, Gómez-Apiñániz, Paula, Papoutsi, Tania, Muñoz-Cánoves, Pura, Méndez-Ferrer, Simón, de la Pompa, José Luis

“…Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic…”
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Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade by Travisano, Stanislao Igor, Oliveira, Vera Lucia, Prados, Belén, Grego-Bessa, Joaquim, Piñeiro-Sabarís, Rebeca, Bou, Vanesa, Gómez, Manuel J, Sánchez-Cabo, Fátima, MacGrogan, Donal, de la Pompa, José Luis

“…Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development…”
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Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet by Nus, Meritxell, Sage, Andrew P, Lu, Yuning, Masters, Leanne, Lam, Brian Y H, Newland, Stephen, Weller, Sandra, Tsiantoulas, Dimitrios, Raffort, Juliette, Marcus, Damiënne, Finigan, Alison, Kitt, Lauren, Figg, Nichola, Schirmbeck, Reinhold, Kneilling, Manfred, Yeo, Giles S H, Binder, Christoph J, de la Pompa, José Luis, Mallat, Ziad

“…Splenic marginal zone B cells suppress atherosclerosis in mice by dampening the proatherogenic T follicular helper response via a PDL1-dependent interaction…”
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Sequential Notch activation regulates ventricular chamber development by D’Amato, Gaetano, Luxán, Guillermo, del Monte-Nieto, Gonzalo, Martínez-Poveda, Beatriz, Torroja, Carlos, Walter, Wencke, Bochter, Matthew S., Benedito, Rui, Cole, Susan, Martinez, Fernando, Hadjantonakis, Anna-Katerina, Uemura, Akiyoshi, Jiménez-Borreguero, Luis J., de la Pompa, José Luis

“…Ventricular chambers are essential for the rhythmic contraction and relaxation occurring in every heartbeat throughout life. Congenital abnormalities in…”
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Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium by VanDusen, Nathan J., Casanovas, Jose, Vincentz, Joshua W., Firulli, Beth A., Osterwalder, Marco, Lopez-Rios, Javier, Zeller, Rolf, Zhou, Bin, Grego-Bessa, Joaquim, De La Pompa, José Luis, Shou, Weinian, Firulli, Anthony B.

“…The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial,…”
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Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve by Piñeiro-Sabarís, Rebeca, MacGrogan, Donal, de la Pompa, José Luis

“…The cardiac outflow tract (OFT) transiently links the ventricles to the aortic sac and forms the arterial valves. Abnormalities in these valves, such as…”
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RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells by Robert-Moreno, Àlex, Espinosa, Lluís, de la Pompa, José Luis, Bigas, Anna

“…Definitive hematopoiesis in the mouse embryo originates from the aortic floor in the P-Sp/AGM region in close association with endothelial cells. An important…”
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Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop by Del Monte, Gonzalo, Grego‐Bessa, Joaquím, González‐Rajal, Alvaro, Bolós, Victoria, De La Pompa, José Luis

“…Signaling through Notch receptors, which regulate cell fate decisions and embryonic patterning, requires ligand‐induced receptor cleavage to generate the…”
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FADD: Essential for Embryo Development and Signaling from Some, but Not All, Inducers of Apoptosis by Yeh, Wen-Chen, de la Pompa, José Luis, McCurrach, Mila E., Shu, Hong-Bing, Elia, Andrew J., Shahinian, Arda, Ng, Michelle, Wakeham, Andrew, Khoo, Wilson, Mitchell, Kyran, El-Deiry, Wafik S., Lowe, Scott W., Goeddel, David V.

“…FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1…”
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Don’t Break the Axis: Placental Inflammation Leads to Congenital Heart Disease by de la Pompa, José Luis

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Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function by Salguero-Jiménez, Alejandro, Grego-Bessa, Joaquim, D'Amato, Gaetano, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…During vertebrate cardiac development NOTCH signaling activity in the endocardium is essential for the crosstalk between endocardium and myocardium that…”
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Intricate MIB1-NOTCH-GATA6 Interactions in Cardiac Valvular and Septal Development by Piñeiro-Sabarís, Rebeca, MacGrogan, Donal, de la Pompa, José Luis

“…Genome-wide association studies and experimental mouse models implicate the and genes in congenital heart disease (CHD). Their close physical proximity and…”
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Identification of a peripheral blood gene signature predicting aortic valve calcification by MacGrogan, Donal, Martínez-Poveda, Beatriz, Desvignes, Jean-Pierre, Fernandez-Friera, Leticia, Gomez, Manuel José, Gil Vilariño, Eduardo, Callejas Alejano, Sergio, Garcia-Pavia, Pablo, Solis, Jorge, Lucena, Joaquín, Salgado, David, Collod-Béroud, Gwenaelle, Faure, Emilie, Théron, Alexis, Torrents, Julia, Avierinos, Jean-François, Montes, Lorena, Dopazo, Ana, Fuster, Valentín, Ibañez, Borja, Sánchez-Cabo, Fátima, Zaffran, Stephane, de la Pompa, José Luis

“…Calcific aortic valve disease (CAVD) is a significant cause of illness and death worldwide. Identification of early predictive markers could help optimize…”
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