Search Results - "Pomie, Celine"

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance by Denou, Emmanuel, Lolmède, Karine, Garidou, Lucile, Pomie, Celine, Chabo, Chantal, Lau, Trevor C, Fullerton, Morgan D, Nigro, Giulia, Zakaroff‐Girard, Alexia, Luche, Elodie, Garret, Céline, Serino, Matteo, Amar, Jacques, Courtney, Michael, Cavallari, Joseph F, Henriksbo, Brandyn D, Barra, Nicole G, Foley, Kevin P, McPhee, Joseph B, Duggan, Brittany M, O'Neill, Hayley M, Lee, Amanda J, Sansonetti, Philippe, Ashkar, Ali A, Khan, Waliul I, Surette, Michael G, Bouloumié, Anne, Steinberg, Gregory R, Burcelin, Rémy, Schertzer, Jonathan D

“…Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of…”
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Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy by Paillasse, Michael R, Esquerré, Michael, Bertrand, Florie A, Poussereau-Pomié, Céline, Pichery, Mélanie, Visentin, Virgile, Gueguen-Dorbes, Geneviève, Gaujarengues, Florence, Barron, Pauline, Badet, Gaelle, Briaux, Anne, Ancey, Pierre-Benoit, Sibrac, David, Erdociain, Eric, Özcelik, Dennis, Meneyrol, Jérôme, Martin, Valérie, Gomez-Brouchet, Anne, Selves, Janik, Rochaix, Philippe, Battistella, Maxime, Lebbé, Céleste, Delord, Jean-Pierre, Dol-Gleizes, Frédérique, Bono, Françoise, Blanc, Isabelle, Alam, Antoine, Hunneyball, Ian, Whittaker, Mark, Fons, Pierre

“…The receptor tyrosine kinase VEGFR-3 plays a crucial role in cancer-induced angiogenesis and lymphangiogenesis, promoting tumor development and metastasis…”
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Metagenome and metabolism: the tissue microbiota hypothesis by Burcelin, Rémy, Serino, Matteo, Chabo, Chantal, Garidou, Lucile, Pomié, Celine, Courtney, Michael, Amar, Jacques, Bouloumié, Anne

“…Over the last decade, the research community has revealed the role of a new organ: the intestinal microbiota. It is considered as a symbiont that is part of…”
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CX3CR1 regulates gut microbiota and metabolism. A risk factor of type 2 diabetes by Pomié, Celine, Servant, Florence, Garidou, Lucile, Azalbert, Vincent, Waget, Aurélie, Klopp, Pascale, Garret, Céline, Charpentier, Julie, Briand, Francois, Sulpice, Thierry, Lelouvier, Benjamin, Douin-Echinard, Victorine, Burcelin, Rémy

“…Objective The intestinal microbiota to immune system crosstalk is a major regulator of metabolism and hence metabolic diseases. An impairment of the chemokine…”
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Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease by Luche, Elodie, Robert, Virginie, Cuminetti, Vincent, Pomié, Celine, Sastourné-Arrey, Quentin, Waget, Aurélie, Arnaud, Emmanuelle, Varin, Audrey, Labit, Elodie, Laharrague, Patrick, Burcelin, Remy, Casteilla, Louis, Cousin, Beatrice

“…Activation and increased numbers of inflammatory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases. Up to now, AT macrophages (ATM)…”
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Mouse and human CD8+ CD28low regulatory T lymphocytes differentiate in the thymus by Vuddamalay, Yirajen, Attia, Mehdi, Vicente, Rita, Pomié, Céline, Enault, Geneviève, Leobon, Bertrand, Joffre, Olivier, Romagnoli, Paola, Meerwijk, Joost P.M.

“…Summary Regulatory T (Treg) lymphocytes play a central role in the control of immune responses and so maintain immune tolerance and homeostasis. In mice,…”
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Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response by Blasco-Baque, Vincent, Garidou, Lucile, Pomié, Céline, Escoula, Quentin, Loubieres, Pascale, Le Gall-David, Sandrine, Lemaitre, Mathieu, Nicolas, Simon, Klopp, Pascale, Waget, Aurélie, Azalbert, Vincent, Colom, André, Bonnaure-Mallet, Martine, Kemoun, Philippe, Serino, Matteo, Burcelin, Rémy

“…To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched…”
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Immuno-microbiota cross and talk: The new paradigm of metabolic diseases by Burcelin, Rémy, Garidou, Lucile, Pomié, Céline

“…Highlights ► A new paradigm is needed for the treatment of metabolic diseases. ► Bacterial fragments such as lipopolysaccharides initiate high fat diet induced…”
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The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease by Garidou, Lucile, Pomié, Céline, Klopp, Pascale, Waget, Aurélie, Charpentier, Julie, Aloulou, Meryem, Giry, Anaïs, Serino, Matteo, Stenman, Lotta, Lahtinen, Sampo, Dray, Cedric, Iacovoni, Jason S., Courtney, Michael, Collet, Xavier, Amar, Jacques, Servant, Florence, Lelouvier, Benjamin, Valet, Philippe, Eberl, Gérard, Fazilleau, Nicolas, Douin-Echinard, Victorine, Heymes, Christophe, Burcelin, Rémy

“…A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown…”
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Abstract 3768: Identification of a novel non-brain penetrant A2AR inhibitor and proof-of-concept of CD73 and A2AR/CD73 small-molecule inhibitors for cancer immunotherapy by Fons, Pierre, Bell, Andy, Esquerre, Michael, Versluys, Stephanie, Bertrand, Florie, Poussereau-Pomie, Celine, Schreyer, Adrian, Cox, Richard, Besnard, Jeremy, Paillasse, Michael, Swindells, Mark, Lisztwan, Joanna, Johnstone, Craig, Whittaker, Mark, Hopkins, Andrew

“…Abstract Adenosine, generated by CD73 is a key driver of immunosuppression in the hypoxic tumour microenvironment (TME). In immune-inflamed tumours, with CD8+…”
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Abstract 2753: Translation to the clinic of EVT801: A novel immune-oncology agent for addressing innate-driven immunosuppression into the tumor microenvironment and expanding patient population responding to immune checkpoint therapies by Fons, Pierre, Esquerre, Michael, Mazieres, Julien, Rochaix, Philippe, Gomez-Brouchet, Anne, Alam, Antoine, Bertrand, Florie, Poussereau-Pomie, Celine, Meneyrol, Jerome, Pradines, Anne, selves, janick, Rouquette, Isabelle, Blanc, Isabelle, Bono, Francoise, O'Brien, Donogh P., Paillasse, Michael, Lisztwan, Joanna, Whittaker, Mark

“…Abstract Amongst resistance mechanisms of immune checkpoint therapies (ICTs), expansion and recruitment of immunosuppressive innate cells and in particular…”
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Abstract 519: EVOEXS21546 is a novel non-brain penetrant A2AR inhibitor for cancer immunotherapy with accelerated drug development by Fons, Pierre, Bell, Andy, Esquerre, Michael, Versluys, Stephanie, Bertrand, Florie, Hopkins-Navratilova, Iva, Robinson, Sean, Visentin, Virgile, Schreyer, Adrian, Cox, Richard, Mirey, Emilie, Pelissier, Emilie, bergeaud, Celia, Culurgioni, Simone, Besnard, Jeremy, Payne, Andrew, Menegotto, Jerome, Machet, Frederic, Poussereau-Pomie, Celine, Cogo, Eric, Paillasse, Michael, Ferigo, Federica, Pagliarusco, Sabrina, Lisztwan, Joanna, Whittaker, Mark, Johnstone, Craig, Hopkins, Andrew

“…Abstract Evotec and Exscientia are collaborating to develop an innovative drug discovery platform for accelerating small molecule development in…”
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Abstract 507: Identification of CD73 and A2AR/CD73 small molecule inhibitors for cancer immunotherapy as single agents or in combination with Immune-checkpoint therapies by Fons, Pierre, Bell, Andrew, Esquerre, Michael, Versluys, Stephanie, Bertrand, Florie, Schreyer, Adrian, Hopkins-Navratilova, Iva, Hernani, Leonardo-Silvestre, Bergeaud, Celia, Poussereau-Pomie, Celine, Marchand, Ghislaine, Robinson, Sean, Culurgioni, Simone, Cox, Richard, Besnard, Jeremy, Payne, Andrew, Ray, Peter, Pelissier, Emilie, Paillasse, Michael, Lisztwan, Joanna, Johnstone, Craig, Whittaker, Mark, Hopkins, Andrew

“…Abstract Adenosine generated by CD73 is a key driver of immunosuppression in the hypoxic tumour microenvironment (TME) and particularly involved in angiogenic…”
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Gut Microbiota Cool-Down Burning Fat! The Immune Hypothesis by Burcelin, Remy, Pomié, Céline

“…Obesity is characterized by gut microbiota dysbiosis and reduced thermogenic activity of brown adipose tissue. A recent study reveals that gut microbiota…”
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Abstract 3203: Cutting edge biomarkers strategy to provide early insights into activity of EVT-801, a novel selective VEGFR-3 inhibitor that targets tumor angiogenesis during the FIH clinical trial by Paillasse, Michael R., Garner, James, Fitzgerald, Michael, Davenne, Lise, Ancey, Pierre-Benoit, Poussereau-Pomie, celine, Esquerre, Michael, Badet, Gaelle, Tuyaret, Joel, Mandron, Marie, Rochaix, Philippe, Ayyoub, Maha, Scarlata, Clara Maria, Ménétrier-Caux, Christine, CAUX, Chrsitophe, Cassier, Philippe, Delord, Jean-Pierre, Roca, Carlos Gomez, Fons, Pierre

“…Abstract Introduction: EVT801 is a highly selective small molecule inhibitor of VEGFR3 and acts by inhibiting lymphangiogenesis and tumor angiogenesis in and…”
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Changes in Lipoprotein Kinetics Associated With Type 2 Diabetes Affect the Distribution of Lipopolysaccharides Among Lipoproteins by Vergès, Bruno, Duvillard, Laurence, Lagrost, Laurent, Vachoux, Christelle, Garret, Céline, Bouyer, Karine, Courtney, Michael, Pomié, Céline, Burcelin, Rémy

“…Context: Lipopolysaccharides (LPSs) are inflammatory components of the outer membrane of Gram-negative bacteria and, in plasma, are mostly associated with…”
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Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia by Pomié, Céline, Blasco-Baque, Vincent, Klopp, Pascale, Nicolas, Simon, Waget, Aurélie, Loubières, Pascale, Azalbert, Vincent, Puel, Anthony, Lopez, Frédéric, Dray, Cédric, Valet, Philippe, Lelouvier, Benjamin, Servant, Florence, Courtney, Michael, Amar, Jacques, Burcelin, Rémy, Garidou, Lucile

“…Abstract Objective To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota…”
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Mouse and human CD8(+) CD28(low) regulatory T lymphocytes differentiate in the thymus by Vuddamalay, Yirajen, Attia, Mehdi, Vicente, Rita, Pomié, Céline, Enault, Geneviève, Leobon, Bertrand, Joffre, Olivier, Romagnoli, Paola, van Meerwijk, Joost P M

“…Regulatory T (Treg) lymphocytes play a central role in the control of immune responses and so maintain immune tolerance and homeostasis. In mice, expression of…”
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Defective NOD 2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance by Denou, Emmanuel, Lolmède, Karine, Garidou, Lucile, Pomie, Celine, Chabo, Chantal, Lau, Trevor C, Fullerton, Morgan D, Nigro, Giulia, Zakaroff‐Girard, Alexia, Luche, Elodie, Garret, Céline, Serino, Matteo, Amar, Jacques, Courtney, Michael, Cavallari, Joseph F, Henriksbo, Brandyn D, Barra, Nicole G, Foley, Kevin P, McPhee, Joseph B, Duggan, Brittany M, O'Neill, Hayley M, Lee, Amanda J, Sansonetti, Philippe, Ashkar, Ali A, Khan, Waliul I, Surette, Michael G, Bouloumié, Anne, Steinberg, Gregory R, Burcelin, Rémy, Schertzer, Jonathan D

“…Abstract Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD 2…”
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CD8 +CD28 − Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice by MÉnager–Marcq, Ingrid, PomiÉ, CÉline, Romagnoli, Paola, van Meerwijk, Joost P.M.

“…Background & Aims: Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4 + T lymphocytes have…”
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