Search Results - "Pomés, A"

Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity by Mueller, G. A., Gosavi, R. A., Pomés, A., Wünschmann, S., Moon, A. F., London, R. E., Pedersen, L. C.

“…To cite this article: Mueller GA, Gosavi RA, Pomés A, Wünschmann S, Moon AF, London RE, Pedersen LC. Ara h 2: crystal structure and IgE binding distinguish two…”
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Intrinsic properties of allergens and environmental exposure as determinants of allergenicity by POMES, A

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Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences by Radauer, C., Nandy, A., Ferreira, F., Goodman, R. E., Larsen, J. N., Lidholm, J., Pomés, A., Raulf‐Heimsoth, M., Rozynek, P., Thomas, W. R., Breiteneder, H.

“…The IUIS Allergen Nomenclature Sub‐Committee, under the auspices of the World Health Organization and the International Union of Immunological Societies,…”
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Quantification of Ara h 1 in peanuts: why roasting makes a difference by Pomés, A., Butts, C. L., Chapman, M. D.

“…Summary Background Increased allergenicity of roasted vs. raw peanut has been reported by showing higher IgE binding to roasted peanut extracts. Objective To…”
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Serological, genomic and structural analyses of the major mite allergen Der p 23 by Mueller, G. A., Randall, T. A., Glesner, J., Pedersen, L. C., Perera, L., Edwards, L. L., DeRose, E. F., Chapman, M. D., London, R. E., Pomés, A.

“…Summary Background Der p 23 was recently identified in a European population as a major allergen and potentially a chitin binding protein. Objective This study…”
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Recombinant Der p 7 Constitutively Expressed in a Eukaryotic System Shows the Same Antigenic Properties as the Natural Allergen by Glesner, J, Chapman, M.D, Pomés, A

“…Two major bands of 22 and 26 kDa were observed in culture supernatants by silver-stained SDS-PAGE gels, corresponding to the 22.2 kDa predicted molecular…”
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IgE Antibody Binding Sites On Mite Group I Allergens Defined By X-ray Crystallography And Site-directed Mutagenesis by Pomés, A, Glesner, J, Vailes, L.D, Minor, W, Chruszcz, M, Chapman, M.D

“…Site-directed mutagenesis analysis of residues from epitopes identified by X-ray crystallography allows the location of amino acids important for…”
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American Cockroach Allergen rPer a 3 Expressed in Pichia pastoris by Glesner, J, Arruda, L.K, Chapman, M.D, Pomés, A

“…Per a 3, an American cockroach (Periplaneta americana) allergen shows homology to hemocyanin superfamily proteins and is reported to show skin test reactivity…”
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Structural Analysis of Der f 1 and Der p 1 Allergen-Antibody Complexes Explains Cross-reactivity of Group 1 Allergens by Chruszcz, M, Chapman, M.D, Vailes, L.D, Pomés, A, Minor, W

“…In both allergens the epitope is not only formed by the same amino acids, but their conformations are also the same. [...]the amino acids forming the epitope…”
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Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products by Mueller, G. A., Maleki, S. J., Johnson, K., Hurlburt, B. K., Cheng, H., Ruan, S., Nesbit, J. B., Pomés, A., Edwards, L. L., Schorzman, A., Deterding, L. J., Park, H., Tomer, K. B., London, R. E., Williams, J. G.

“…Background Recent immunological data demonstrated that dendritic cells preferentially recognize advanced glycation end product (AGE)‐modified proteins,…”
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Does the Structural Symmetry of Cockroach Allergen Bla g 2 Determine Symmetry of Antigenic Determinants for IgE antibody Binding? by Stohr, L, Wünschmann, S, Chapman, M.D, Li, M, Wlodawer, A, Gustchina, A, Pomés, A

“…Rationale Bla g 2 is a potent German cockroach allergen, homologous to aspartic proteases and has a bilobal three-dimensional structure, originated from gene…”
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The Crystal Structure of the Complex of Bla g 2 with an Antibody Fragment Reveals Cation-pi and Sugar Interactions by Pomés, A, Li, M, Wünschmann, S, King, E.M, Alexandratos, J, Chapman, M.D, Wlodawer, A, Gustchina, A

“…Conclusions Analysis of the allergen-antibody interactions from the crystal structure of a Bla g 2-Fab' complex enables a rational approach for the design of…”
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Validation of Phage Display and Computational Algorithm for Mapping Conformational Ige Epitopes by Tiwari, R, Negi, S, Midoro-Horiuti, T, Pomés, A, Chapman, M.D, Braun, W, Goldblum, R.M

“…Amino acid sequences from the selected phage were matched with clusters of amino acid residues on the surface of the high resolution 3-D crystal structure of…”
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Identification of Cockroach Allergen using Proteomic Analysis by Arruda, L.K, Barbosa, M.C.R, Santos, A.B.R, Santos, L.D, Palma, M.S, Ferreira-Briza, F, Briza, P, Erler, A, Chapman, M.D, Pomés, A

“…Immunoblotting was performed using undiluted serum pool constructed with sera from 27 patients with asthma and/or rhinitis allergic to P. americana who…”
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The X-Ray Crystal Structure of Two Complexes of the Cockroach Allergen Bla g 2 with Fragments of Monoclonal Antibodies Defines Two Non-overlapping Epitopes by Pomés, A, Li, M, Glesner, J, Wünschmann, S, King, E.M, Chapman, M.D, Wlodawer, A, Gustchina, A

“…Analysis of the crystal structure of Bla g 2-Fab/Fab'-mAb complexes enables the identification of antigenic determinants on the allergen and subsequent…”
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Sequence Analysis of Monoclonal Antibodies Against Group 1 Dust Mite Allergens by Williams, K.T, Chapman, M.D, Pomés, A

“…The highest variability in amino acid sequence is in the CDR2 and CDR3 from the heavy chain, and in length is in the CDR3 from heavy chain, which is thought to…”
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Crystal Structures of Der f 1, Der p 1 and a Der f 1 Allergen-Antibody Complex: Localization of Antibody Binding Epitopes by Chruszcz, M, Chapman, M.D, Stura, E.A, Vailes, L.D, Saint-Remy, J, Minor, W, Pomés, A

“…DNA encoding for Der f 1 has been mutated for expression of single epitope mutants in Pichia pastoris to analyze the effect of specific amino acids on IgE…”
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Cockroach Allergen Bla g 2 Dimerizes in a Crystal Complex with an Antibody Fragment by Pomés, A, Li, M, Wünschmann, S, Chapman, M.D, Wlodawer, A, Gustchina, A

“…Determination of the molecular structure of a Bla g 2-Fab' complex enables a rational approach to study the effect of dimerization on allergenicity and…”
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Mapping of Antigenic Determinants on Bla g 2 surface by Wünschmann, S, Li, M, Gustchina, A, Wlodawer, A, Chapman, M, Pomés, A

“…Based on the mAb-allergen interaction from the crystal structure, two additional Bla g 2 mutants with multiple amino acid changes were created to eliminate the…”
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Functional study of the cockroach allergen Bla g 2 by Wünschmann, S., Chapman, M.D., Gustchina, A., Wlodawer, A., Li, M., Pomés, A.

“…Inhibition by pepstatin, but not PMSF (a serine protease inhibitor) indicated that the activity was aspartic proteinase…”
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